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- Intermittent lameness in any or all of the limbs that becomes more constant over 1-3 months; acute lameness may be due to a bone fracture
- Hard, obvious swelling over a long bone of a limb
- Loss of appetite and significant weight loss
- Progressively worsening pain
- Generalized weakness
- Respiratory difficulties
- Chondrosarcoma: Less aggressive than osteosarcoma and has a lower tendency to spread.
- Fibrosarcoma: Usually localized and has a low metastasizing rate unless the tumor is of high grade.
- Synovial Cell Carcinoma: Grades 1 and 2 sarcomas are potentially curable. Grade 3 usually results in death within several months.
- Osteosarcoma: This is the most common type in cats and the most aggressive. Potential for cure is favorable through amputation of the affected limb since the metastatic potential in cats is low.
- Physical and orthopedic exam
- Radiographs (x-rays) of the observed area as well as the pelvis and chest to detect metastasis
- Histopathology (tissue changes)
- Chemistry profile to check organ function
- Blood tests, including a CBC
- CT, PET, and/or MRI scans
- Possibly a whole body bone scan with a radioactive marker placed in the bloodstream
- Ultrasound, especially of the heart
- Urinalysis to determine kidney function
- Tissue biopsy
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- Osteosarcoma: With amputation alone, a survival time of 3-5 months is common. Amputation along with chemotherapy has a survival time of about 1-4 years.
- Chondrosarcoma and Fibrosarcoma: Amputation may be curative without chemotherapy.
- Synovial Cell Sarcoma: Grade 1 and 2 tumors are often cured with amputation alone. Patients with grade 3 tumors usually die within seven months.
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