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What is Advantage Flea Medication Allergy?

Advantage flea treatment is made by the company Bayer, and its active ingredient is imidacloprid. Imidacloprid is an effective and typically safe-to-use insecticide that kills fleas. Although it is considered safe to use, this active ingredient can cause adverse reactions by cats. 

This monthly treatment should not be used on cats younger than 7 months of age and should only be used by carefully following the instructions. It is to be applied between the shoulder blades of the back and you should only use the specific dosage according to your cat’s weight. 

The ingredient, imidacloprid, affects the nervous system of the fleas and paralyzes them. The fleas eventually die within twelve hours. Within just five minutes of applying Advantage, the fleas stop biting and the larvae are killed. This waterproof treatment lasts for about one month, and then needs to be reapplied. 

Many cat owners use Advantage flea medication because it is considered safe and effective. Other benefits of this medication are it is inexpensive, easy to use, and readily available in many stores.

Advantage flea medication is commonly used to rid cats of fleas and is considered safe. However, some cats develop an allergy to the medication, and if this occurs, it is important to contact your veterinarian.

Symptoms of Advantage Flea Medication Allergy in Cats

If your cat licks any of the product or has an adverse reaction to the skin, he will exhibit the following symptoms. Symptoms of Advantage flea treatment allergy in cats include:

  • Drooling
  • Vomiting
  • Diarrhea
  • Irritation of the skin
  • Shaking of the head
  • Seizures
  • Loss of appetite
  • Lethargy
  • Difficulty breathing
  • Itching
  • Biting at the skin

Types

There are many types of safe flea treatments available on the market today; however they can still cause a reaction if not used properly or if your cat is allergic. Other types of active ingredients in flea medications include:

  • Selamectin
  • Fipronil
  • Methoprene

Causes of Advantage Flea Medication Allergy in Cats

Advantage flea treatment is known to be safe for cats; however, some cats may develop a reaction to the active ingredient. Causes of a reaction include:

  • The medication is absorbed through the skin
  • The medication can enter the cat’s bloodstream
  • The active ingredient can cause nerve damage
  • The cat may suffer from an accidental overdose

Diagnosis of Advantage Flea Medication Allergy in Cats

If you suspect that your cat is having a reaction to his Advantage flea medication, contact your veterinarian. Take the container and packaging to the appointment with you so your veterinarian can be sure of what is giving your cat problems. Your veterinarian will ask you questions about the type of medication he is on to help fight his fleas. He will then take a closer look at his symptoms and gather information about them, such as when they began and the severity. 

The veterinarian may thoroughly wash and rinse your dog to remove any of the treatment and begin giving him fluids to help with hydration and to stabilize his symptoms. He will take blood work, urinalysis, and a biochemistry profile. The blood testing will focus on your feline’s serum levels. Although blood testing and urine testing are not always absolute, your veterinarian will be able to rule out other illnesses by taking a close look at your cat’s symptoms and having the knowledge that he began having a reaction after the application of the product.

Treatment of Advantage Flea Medication Allergy in Cats

Unfortunately, there is no treatment for imidacloprid toxicity. Your veterinarian will explain to you what you can do at home, and will treat his symptoms. Treatment methods may include:

Decontamination

Your veterinarian may have already washed and thoroughly rinsed your cat to help rid his skin and fur of the toxic ingredient.

Avoid Exposure

Your veterinarian will suggest to you that you avoid all further applications of the medication. He may also suggest holistic methods to help control and get rid of fleas.

Gastric Lavage

For severe cases of poisoning, such as if your cat has ingested the medication, your veterinarian may perform gastric lavage to help rid his stomach contents of the medication. This treatment method will be followed up with a dosage of activated charcoal and possibly a dosage of laxatives.

Fluids

Your veterinarian may want to keep your cat for a day or two and monitor his progress as he is on IV fluids. The fluids will help your cat remain hydrated and help further flush out any toxins.

Recovery of Advantage Flea Medication Allergy in Cats

Most cats have an allergic reaction if they were given too much of the product or if they ingested a specific amount of the medication. Your veterinarian will communicate with you about your cat’s prognosis. Once you take your cat home, continue to monitor him for any other side effects or reactions. Be sure to give him plenty of fresh water during the day and night and monitor his drinking and urination habits. 

In order to avoid this from occurring again, you may want to consider holistic remedies to help control fleas. You can talk to your veterinarian about the types that are available to help your cat during peak flea seasons. If you have any questions about the main ingredients of products that can be used to help fight fleas, ask your veterinarian.

Advantage Flea Medication Allergy Questions and Advice from Veterinary Professionals

Mazie
tabby
4 Months
Fair condition
1 found helpful
Fair condition

Has Symptoms

Medicinal smell

Hi. I have a large cat and a 4.5 pound kitten (4 months). I purchased the appropriate sized advantage for both cats. Got distracted by kids and put the adult advantage on the kitten. What should I do? This was almost 3 hours ago and she seems fine except for a very strong medicine smell. Should I try washing it off? Take her to vet? Again, she seems perfectly fine for now.

My kitty is 16 years old. She’s only about 4 lbs. Her age has brought on chronic gastrointestinal problems. Otherwise she’s a good eater. Thin, but she purrs all the time. Snuggling and poops fine. Feisty to the Ferrells too. She can really scrap still. No controlling her temper lol. I’m just worried about using advantage 2 for small cats on her this flea season. She has a few fleas. What should I do for her? We can’t afford the vet right now. She’s spayed a long time ago. I mean, we take very good care of her. I just need to know if I can put advantage on her safety? Does anyone have any advice?

My elderly cat died a few hours after applying Advantage. My two younger cats are fine. They are all over 9 lbs.

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B
Domestic shorthair
12 Years
Serious condition
0 found helpful
Serious condition

Our 12 year old, 14 pound cat reacted by losing his fur in a 3" radius at the application site between shoulders after Advantage II for large cats was applied. He's an indoor cat, and now has a huge bald spot PLUS fleas still alive.

My cat has hair loss at the application site too. Nobody seems to offer an answer here on this site. I also wonder if the hair will ever grow back again.

Hi - does anyone who had cat hair loss have further comment on how their cat is doing? My cat has hair loss too and he seems fine in every other way. But it’s troubling to see this large bald spot now where I gave him Advantage! Wondering if there is anything specific to do, or how long it takes for cat to recover?

MY Ginger cat seemed to lose hair every year in about the same spot between the shoulder blades every summer, made no connection to the flea treatment until I deflead them all with Advantage last week again and low behold a day or so later I noticed that bald patch again, skin is really smooth and totally hairless within a day or 2 it has dried up and developed a scab that has quickly started to curl up and away from the body and fur is already growing back - the flea treatment is the only unusual thing, so it must the cause. Would love to know what sort of topical cream I can put on it.

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Marli
Norwegian forest cat
3 Years
Mild condition
0 found helpful
Mild condition

Has Symptoms

Trembling
Tremors
Shaking

My three year old Norwegian Forest cat was treated with Advantage II Large Cats medicine on Friday. Today is Sunday, and she is trembling/mild tremors. No other symptoms are being displayed. Is this serious, and what should I do about it? Can this kill my cat?

Please tell me what happened to your cat my cat is showing these same signs

My Norwegian same thing. Hes gonna be 9 this year. Its been a week since I applied it him. WHY....IS THIS HAPPENING? I just spent over $1500 on a bladder issue, changed his diet to Royal Cannin. This has NEVER happened in the past. Will this pass?

Did the cats live? I drove all over looking for a vet that was open last night. I scrubbed her in a bath to remove. Shes still shaking.

My cat Tommy started fitting the day after I put advantage spot on flea treatment on him. I am so angry. He now has to have medication to control the fits. Never ever use this treatment!!!

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Henry
mixed
4 Years
Fair condition
0 found helpful
Fair condition

Has Symptoms

Weeping eyes
Squinting

Hi,

I’ve tried advantage on my two cats twice, the first time they both bolted like I’d branded them with a hot poker.
Henry, one of my cants started squinting and his eye became very weepy, I thought I must have gotten some in my hand and brushed his face accidentally, but he had the same reaction the second time I put it on him! He couldn’t really open his eyes for a couple of hours, Is this an allergic reaction? How do I combat it in future?

Thanks

My cat has had this same reaction to Advantage II and I will not apply it this year - his eyes even had a pinkish colored drainage afterward that I believe was blood tinged.

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Bocker
DOMESTIC
7 Months
Serious condition
0 found helpful
Serious condition

Has Symptoms

Vomiting

My three cats were all spayed on 10/22 also they had their rabies and distemper shot and flea treatments for three days now my cats have really had no appitite and been vomiting i thought maybe they licked the flea medicine off one another some of the vomit has been food some bile and some foam the cats are all getting up and moving around still but i figured from the surgury they would be lazy and have. A poor appitite. But im getting worried their vomiting so much? And not keeping much down. And dont really have money for a vet after just paying for this.

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Penny
Calico
2 Years
Fair condition
0 found helpful
Fair condition

Has Symptoms

Itching

I have a 2 year old cat, weighs about 12 pounds, applied advantage 2 after finding fleas on the kitten who is kept only downstairs, saw the 2 year old itching, now after application the cat won’t stop shaking her head, itching around her head and biting at her paws. Is this normal? Or does she have fleas still

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Brass
Mixed longhair
3 Years
Mild condition
0 found helpful
Mild condition

Has Symptoms

lethergy
Vomiting

I applied Advantage 2 large cat to Brass, hes 13.5 lbs and 3 years old. I did this 3 days ago. The day after i saw that he has a small bare patch of skin, about the size of a pea. Then yesterday he vomited twice around 2 pm, mostly food, then later a couple more time just stomach bile, and in the middle of the night he was dry heaving. Hes been lethergic all yesterday too. Once my vet clinic opens in the morning i'll bring him in to see what they can do, and get an allergy test to see if it actually was a reaction.

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Jax
DOMESTIC
3 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Ear twitching

I used Advantage II for large cats, on my cat who is roughly 10 lbs. He has had this in the past with no problems at all, but this time he is just not himself. He drooled and foamed at the mouth after about an hour. It has been almost 24 hours, and he is so sleepy, hiding, has scratched a ton of fur off, and his ears are twitching constantly. He seems fine otherwise.. still purring and eating. Is he going to be okay? I’ve just never seen the ear twitching before.

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Ladybug
Calico singapura mix
16 Years
Fair condition
0 found helpful
Fair condition

Has Symptoms

Old age

Medication Used

Advantage 2

My small elderly cat is really old. I’m worried about putting advantage on her this season. She’s lost weight despite her healthy eating habits. She potty’s fine.just aging. Weight is about 4lbs. She’s always been a tiny cat. Please help!

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Oliver
Dlh
11 Years
Mild condition
0 found helpful
Mild condition

Has Symptoms

Head shaking, scratching at head,

My cat began shaking his head vigorously the day after applying Advantage II small cat drops. I didn't connect the two initially. I checked his ears for a problem. I applied it on top of his head between his ears so he wouldn't lick it off. Once i realized what it may be, i used a wet cloth with waterless shampoo to scrub his head and found several bald spots. He seemed to find relief with this as he didn't struggle at all like when i checked his ears. I'm keeping a close eye on him and will find a different flea med from now on. I think i used Frontline in the past and may go back to that

please read about
Frontline Plus before using it On your cat! Used Tuesday On my 6 cats, they have had it before. Yesterday Princess became unwell. Her breathing was laboured, her throat seemed swollen and she was lethargic and or to eat or drink. Vet saw her and said she had an allergic reaction. Checked her over and she had two injections - she is still poorly and am sitting up with her. Very worried. Our get no longer recommends Frontline!

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Townsend
Domestic short hair Tabby
1 Year
Mild condition
0 found helpful
Mild condition

Has Symptoms

Moving around quickly
Little foaming at mouth
Acted like wanted to throw up
Shaking Head
Excessive Drooling

I gave my 1 1/2 yr old cat today who weighs 8.8lbs the Advantage II Small Cat (5-9lbs). Little bit after putting it on him all of a sudden he starts shaking his head & drooling really bad and acting weird. He really didnt want to come to me since he was moving around so much. He finally calmed down. So I could look him over. The only thing I can say was he had a reaction to the topical flea medication. It really worried me.He is acting fine now with an occasional shake of the head. But overall fine. It really worried me. Our Vets office is closed now and not open till tomorrow maybe I'll have to check since its Easter. Then they prob wont be.. What should I do to consult with someone.

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Marylyn
tabby
8 Years
Critical condition
0 found helpful
Critical condition

Has Symptoms

stroke, hissing,

My cat acted like she was having a stroke after I applied the Cat Advantage II, she wandered around like she was drunk , this was about 8 hrs after applying it I then gave her a good bath to wash the stuff off, yesterday she was still in the same shape, very sick and miserable, this morning 2 days after the Advantage, she hasn't come home at all I'm afraid she may have gone off to die

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Popeye
Russian Blue
10 Months
Serious condition
0 found helpful
Serious condition

Has Symptoms

Dilated Eyes
No balance
Wobbly
Falling Over

Our vet applied Advantage Plus to our 10 month old male cat. We noticed he was trying to lick the area behind his neck where the product was applied. The vet assured us that it would be impossible to reach the back of his neck and could not ingest it. Several hours later, I noticed my cat could not walk straight without falling, and when standing he would wobble back and forth. His eyes were dilated and his body was trembling. We rushed him to the pet hospital where he stayed overnight receiving IV fluids and a medicine to help metabolize and flush out the Advantage Plus. We brought him home the next day, but he was still unable to walk and was very lethargic. We brought him back to the pet hospital where he stayed for two more nights to receive the IV fluids. This was a very stressful (and expensive) experience, but fortunately our cat made a full recovery. We will not be using this product ever again. If you see your pet trying to lick where the product was applied, either immediately wash it off or put on a neck brace so they can't lick the area.

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Sasha
Scottish Fold
8 Years
Mild condition
1 found helpful
Mild condition

Has Symptoms

lethargy,

My cat was treated for fleas by the vet yesterday. He was given Advantage multi drops on the back of the neck AND sprayed with Frontline all over his body. Is this normal protocol? A few hours after treatment, my cat was depressed and lethargic, altough he still had his appetite. But after 20 hours, I noticed some vomit so decided to give him a bath to remove the medication. There's no Dawn where I live, so I used gentle shampoo without parabens and sulfates. He immediately seemed much better. However, after a few hours, this time I noticed slight twitching of the ears. It's been 27 hours since treatment. The vet thinks it'll all go away within 2 days.

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Fred
domestic short hair
10 Years
Critical condition
0 found helpful
Critical condition

Has Symptoms

Scratched neck until fur gone & s
Scratched his neck

My cat is in critical care right now for pancreatitis. He scratched his neck until all fur gone plus scabs plus eyes weepy.
He showed no other symptoms until four days after application which then vomiting and lethargy.
Fever of 105.6 right now in ICU.
This is insane.

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Blackie
Short haired black cat
2 Years
Serious condition
0 found helpful
Serious condition

Has Symptoms

Hair loss on the area

We applied the approiate dose of Advantage Multi Cat on my black cat and one day later he had a bald spot the size of a nickle where the Advantage was applied and just a few minutes ago another spot has appeared. My vet told me to wash the area with Dawn, which I did, but what can I do to stop the hair loss and will it ever come back?

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Tommy
moggy
8 Years
Serious condition
0 found helpful
Serious condition

Has Symptoms

Seizures

I bought Advantage for my cats. I had both sizes as 2 of my cats are small. I put on the treatment to all 4 of them. Within a say, my 8 year old cat Tommy had a seizure. It was mild to start with. I took him to the vet and he was given medication. He has just had another really bad seizure. He will be on the medication for life. I am so angry.

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Baby
Cat
12 Years
Critical condition
0 found helpful
Critical condition

Has Symptoms

Weight Loss
Pain
Foaming At The Mouth
Vomiting
Hair Loss

After reading about half of everyone's comments, it saddens me to know that this product is even still allowed to be available to purchase on store shelves! It also saddens me that I did not look up this page before forcing my mother to use advantage on her boyfriend's 12 year old cat (as she baby sits for me sometimes so I can work, and my step daughter is highly allergic to fleas). Over two weeks later now his cat is still very lethargic and won't eat, has lost a ton of weight, and constantly cries as if she is in constant pain. She has lost most of her fur, and has absolutely no fur at all at the application site. All of this is still occurring after weeks of vomiting after the application. The vet can't do anything for her and now their only option is to put her to sleep to end her misery. Does anyone know if the side effects will ever stop before they decide to do so!?!?! I'm filled with nothing but guilt and rage right now! I wouldn't think they would actually be able to sell such a product with these extreme side effects! Especially since I have read these comments, it is obviously very common for cats to have these reactions. SOMETHING NEEDS TO BE DONE ! THIS PRODUCT NEEDS TO BE TAKEN OFF THE SHELVES! Legal action needs to be taken! This is WRONG!!!! NEVER USE ADVANTAGE EVER!!!! I know I surely wish I would have read all of this prior to all of this happening! All I can hope is that others do and that they get this horrible product that is literally killing our animals OFF THE SHELVES!!!!

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Slinky
house cat
12 Years
Critical condition
0 found helpful
Critical condition

Has Symptoms

balding on face

Only because I had not been given ANY warning that Advantage 2 is dangerous to cats if applied in the proper dose I started giving my old ill ( chronic URI stablized by steroids ) friend Advantage 2 three four weeks ago maybe I would have given her a second small dose ten days ago , I can't recall and would have done so only if she was scratching. Two days ago she looked the same as she has for the last eight months. Today I found her dead in a box in the kitchen. with a bald spot on her face. I know Advantage killed her.Many other cats have had the Advantage 2 including another with chronic URI and several who have problems that have not revealed themselves through extensive testing. Beware use on an ill cat. SD

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Ozymandias
Flame point siamese
4 Days
Critical condition
0 found helpful
Critical condition

Has Symptoms

Rapid breathing
Rapid blinking
Drooling
staggering
Tremors
Seizures
Lethargy

I treated 6 cats with Advantage II in the same dosages they always received. About 7 hours later I noticed Ozzy acting hyperactive and dashing to hide under/behind things. I checked the application site and it was so fiery red I thought he was bleeding. I washed the area with Dawn dish soap to try to relieve irritation. A couple of hours later I saw his head twitching, some drooling, and pupils dilated and he kept blinking his eyes . Soon he lost all coordination and then went into a full-on thrashing gurgling seizure, at which time we went to the emergency vet, where he was given fluids and anti-convulsants and had to be hospitalized for 12 hours. Three of the other cats showed some loss of coordination, twitching and itchy skin, and hyperactivity followed by lethargy, and all of them lost all appetite for two days.

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Stripe
Maine Coon mix
3 Years
Mild condition
0 found helpful
Mild condition

Has Symptoms

Fainted

With 1-2 minutes after applying the medicine my cat Let out a low meow ( almost slow motion sounding) and passed out. I went over and picked him up. In a couple seconds he came to and looked at me. The support rep was very nice, and had not heard of this happening before. It was the first time for us, and it’s the third month of use. Please call in if it happens, so they know. They will ask for the lot number. We used the large cats version (he is 11lbs).
Otherwise there are no fleas

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Foster
Domestic cat
4 Years
Serious condition
0 found helpful
Serious condition

Has Symptoms

Burnt skin and fur, bleeding

My poor cat had an awful skin reaction to this medication. It literally burned his fur and skin where the product was applied. He has a huge bald spot that was bleeding and is extremely irritated.

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Lily
domestic short hair
1.5 year
Mild condition
1 found helpful
Mild condition

My cat Lily is 1 and 1/2 year old. She recently got fleas coz she goes out even though thts only for short times but many times in a day. I applied advantage ll last Friday like 7 days ago and she still has 1 or 2 semi dead fleas that she is dropping here and there. Also she started scratching only her neck and head but not right after advantage. Thts like 3-4 days ago and she still goes out but I limited it which she is not liking. When she had fleas and I didn't apply anything she was scratching all over her body. Now only head and neck and I'm sad to see her like this. I m thinking to give her bath but I'm scared of that Medication might wash away? Kindly help me

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
You can wash Lily without worrying about the medication, once it is dry you can bathe her without any concerns about washing any the medication as it soaks into the skin and doesn’t remain on the skin. Give Lily a good bath with a flea shampoo and spray all surfaces like beds, sofas and other fabric surfaces with a fipronil spray to treat the environment and wash bedding etc… on a high temperature wash. Regards Dr Callum Turner DVM

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Simba
tabby
5 Years
Mild condition
-1 found helpful
Mild condition

Has Symptoms

none

I put Advantage Multi on my cat 2.5 days ago. I wasn't thinking and a couple minutes later I rubbed him and when I did it got all down his back. I left him alone for a few minutes when he could have licked it. I came back with a wet washcloth and wiped his back with water, leaving it only on the application site. I then monitored him for an hour with no strange symptoms. He seems normal. I am worried as I read adverse reactions could show up much later?

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
There are various different symptoms which may present especially if a cat has licked the medication, it will be well absorbed now and you should just continue to monitor for the time being; however generally if the medication had been licked you would see symptoms of drooling and possibly some twitching afterwards. Regards Dr Callum Turner DVM

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Luke and leia
Cat
11 Weeks
Mild condition
0 found helpful
Mild condition

Has Symptoms

Lathargic

I have 11 week old kittens we used advantage shampoo. They seemed ok but about an hour later they seem really sleepy I don't know if they're just tuckered out or what. Please help

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TIGER
Short haired calico
2 Years
Fair condition
0 found helpful
Fair condition

Has Symptoms

Heavy breathing.
Heavy breathing. Hiding

I'm not sure if they are symptoms of an allergic reaction to flea meds or not. My cat is breathing heavier than normal. He did lick the area. This started after my dog chased my cat through the house and started to bite him. As of right now no other symptoms that I can see.

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Snow
white shorthaired
8 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Lethargy

I applied Advantage II for cats over 9lbs on my adult cat. This is the second time I use it on him, and he is very lethargic. The first time I used it on him he was mildly lethargic, but the symptoms went away the next day. This time its more than before and his pupils are dilated. I used a wet wash cloth to rub off the medication on him. What else can I do to make him better? :(

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
You should use a mild dish soap (like Dawn) to remove any residue from the skin, however there is little else that can be done apart from ensuring that Snow remains hydrated and is otherwise comfortable; also please check that the product you used is for cats as I’ve seen a jump in people using the dog one which is toxic for cats. Keep an eye on Snow and visit your Veterinarian if any symptoms present like tremors or anything else concerning. Regards Dr Callum Turner DVM

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Leo
moggy
5 Months
Fair condition
0 found helpful
Fair condition

Has Symptoms

Vomiting
Loss of Appetite
Sleepiness

Hi,I put advantage flea treatment on my 5 month old kitten and he was fine in the evening and the fine in morn ing ie eating and playing, I went to work and he's not himself he's been sick and is sleeping alot, his sister had flea treatment on aswell but I never saw him groom her, he's had this treatment before and he was fine, I'm probably overreacting but I'm scared he's ingested some from his sister

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
Those topical flea treatments aren't toxic if ingested, and tend to taste bad to discourage that from happening. They can cause systemic reactions of lethargy and decreased appetite, however. If Leo continues to vomit, isn't eating, or is not feeling more like himself tomorrow, it would be a good idea to have him examined by a veterinarian to make sure that he is okay, as this may or may not be related to the Advantage application.

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Skittles
American Shorthair
4 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Swollen face and

I applied Advantage to my cat a couple of hours ago and his face is now swelled up. Is there anything I can do to reduce the swelling? He doesn't appear to have any other issues.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
You could try to give Skittles 5mg of cetirizine (if he isn’t on any other medication) to see if that would help with the swelling, but if the swelling is severe and affecting the breathing you should visit a Veterinarian immediately for an examination. Regards Dr Callum Turner DVM

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Oliver
Cat
4 Years
Fair condition
0 found helpful
Fair condition

Has Symptoms

inappropriate urination

Medication Used

Advantage

I gave my male cat Advantage about four hours ago. A few minutes ago he jumped up on my bed and right in front of me peed all over the bed. Just like he was using the litter box. Is there any relationship?

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
There is no relationship that I am aware of between using Advantage (imidacloprid) and urinating outside of the litter tray, there are instances when a cat may lick the application site which may result in an increase in thirst and urination but not specifically inappropriate urination. Keep an eye on Oliver for the time being and follow up with your Veterinarian if he makes a habit (make sure to wash the bedding as the smell may cause him to urinate again). Regards Dr Callum Turner DVM

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Jet
Domestic short hair cat
17 Years
Serious condition
0 found helpful
Serious condition

My cat had an allergic reaction with serious skin irritation to a Hart's topical flea medication in the past. I am considering Advantage II, however, my cat is old and somewhat debilitated. He weighs approximately 6 lb due to chronic weight loss and is 17 yrs old.
He is an indoor cat.
Is this product an option for an elderly cat?

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
Skin irritation is the most common cited side effect of topical spot on flea and tick medications; it is really a case of trying another product to see if there is a similar reaction or not, however whichever product you used ensure that there are different active ingredients from the Hartz product. Regards Dr Callum Turner DVM

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Mj
Tobie
1 Year
Mild condition
1 found helpful
Mild condition

Has Symptoms

forming at the mouth

i put advantage on my cat she a year old and no sooner got it on her she took off like a bat out of hell and i ran after to see she was forming at the mouth, it scared me to death i picked her up and ran to the bath room put her in sink and got as much of the meds off of her and wiped her mouth out and she seem to be better when i did that. so what I am wondering ca i still give it to her or is it best to leave it off ty julia

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
Skin irritation is the most common side effect of topical spot on flea treatments, so MJ may have felt some irritation; she then may have tried to lick the medication which may cause foaming at the mouth as well. You did the right thing bathing MJ and rinsing the mouth out, keep an eye on her for now and visit your Veterinarian if any other symptoms present. Regards Dr Callum Turner DVM

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Tig
American Short Hair
5 Years
Mild condition
0 found helpful
Mild condition

Has Symptoms

Lethargy
Itchy

I put advantage on my two adult cats. My dog brought in what I thought was fleas (only saw one that might have been a flea but she was itchy too) so everyone got a dose. They both seem a little itchy now. Especially Tig who is probably about ten pounds. He’s the most itchy around his neck where I applied the advantage. I haven’t seen a flea or flea dust on either cat. Is the itching and irritation a bad reaction for Tig? He also seems a little sleepy. Riley and Tig have not been given any flea medication until now.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
The most common side effect reported when using topical spot on medications like Advantage (imidacloprid) is irritation of the application site which may result in itching, redness of the area of application, some hair loss among other symptoms. The active ingredient will be well absorbed by a skin now, so you may bathe the area to remove any residue to see if that makes any improvement. Regards Dr Callum Turner DVM

My cat is also itchy, have treated a hot spot on her neck area where applied. She rolls and licks alot...I am treating with antihistamine she had for the one and only respitory infection she had and crram. Otherwise it's to the vet soon

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Lola
Bengal X
7 Weeks
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Lifeless and very quite

Hi used advocate on my kitten and 24 hours later she was very limp and hardly moving rushed her to the vets and they said it wouldn't have been from the treatment. But to have test and xrays we were looking over a thousand pound in costs. She got worse wry quickly and was put to sleep. Her heart rate was low and glucose was very high. What do u think it could have been the treatment of not feeling very guilty x

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
I'm sorry for the loss of your Lola, that is very sad. That flea product is quite safe if used appropriately, but adverse reactions do occur. It is hard to say whether she had a pre-existing condition that affected her, or if something else was going on, but I'm sure that you and your veterinarian made the right decision. Again, I am sorry for your loss.

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Fuego
Cat
9 Weeks
Fair condition
0 found helpful
Fair condition

Has Symptoms

Itching
Fleas

I have a 9 wk old kitten that I initially applied the advantage II medication as he was infested with fleas. We had to keep him quarantined in the bathroom because of our other cat and he wasn't having any of it so we opted to give him a full bath of warm water and Dawn dish soap to remove majority of the fleas. I believe a good portion of the flea medication washed away as well as I was still finding live, active fleas on him a day after his flea bath. It has been 4 days since his flea bath now and he still has live, active fleas crawling around his head and he's trying to bite them off his body. I went ahead and applied the flea medication again as I had given him a very thorough flea bath and was still seeing live fleas crawling on him. My question is, does advantage II wash off? I did see several articles stating that if you start to see symptoms to wash off the flea treatment with dish soap and warm water. Should I wash off his 2nd flea treatment that I applied to him or monitor him for the time being to watch for any symptoms?

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
All flea products will wash off if they are scrubbed enough. Dawn tends to strip the skin of any oils, which makes the topical product not be able to work. If he isn't' showing any signs of toxicity from the 2nd application, you should be fine to leave that application on to help with his flea problems. If he starts to act unstable, tremors, or seizures, you should wash the medication off and seek veterinary help.

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Dog named Blue Baby
dog
3 Years
Serious condition
0 found helpful
Serious condition

Has Symptoms

Testicular redness

Can Advantage Flea and Tick spray cause a dog's testicles to become bloody looking? He doesn't seem to really be bothered by it. He isn't acting as if itches,hurts or anything. Not even licking. It just really looks bad. Please help.

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
If the spray was applied directly to Blue Baby's scrotum, it may cause some local irritation, otherwise it should not have that effect, and the problem may be unrelated. From your description, he should probably be seen by a veterinarian to find out why the skin there is having that problem and see what can be done about it.

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Lyra
dsh
9 Years
Mild condition
0 found helpful
Mild condition

Has Symptoms

Mild lethargy. Red irritated skin.

I have used Advantage Flea Medication on my DSH cat for the 8 years I have had her. (She is now 9 years old.) I never noticed any reaction before. This time she became a little lethargic. That has passed but she has a red irritated patch where I applied the medication. I have washed off the area with warm water. Should I apply any antibiotic or cortisone cream to the area? Is age a factor? Is she too old for this medication? Thanks.

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
If you washed the medication off, the skin should heal normally, and it would be a good idea to monitor it for less redness. Ant ointment that you put on her skin will end up being licked off, so creams are typically not recommended. If she has the same reaction to the medication the next time you use it, she may need a different flea control, and there are many oral forms available from a veterinarian. I hope that all goes well for her.

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Pyper
Savannah
2 Years
Mild condition
0 found helpful
Mild condition

Has Symptoms

cough
Cough vomit

My 3 adult cats over 9 pounds each are all vommiting and one is coughing 24 hrs post application. Is this common and should I be worried? Advatage flea treatment was reccomended by my vet as they are indoor cats only and she said they did not need added meds for tick prevention

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
I'm not sure if your cats are reacting to Advantage or not, but it seems likely since they are all vomiting and they all had the treatment. It is typically a safe treatment, with few side effects. If they continue to vomit, it would be best to have them seen by your veterinarian to make sure that they don't need further treatment. I hope that they are okay.

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Winter
tabby
3 Years
Mild condition
0 found helpful
Mild condition

Has Symptoms

Vomiting

Hello, I applied flea medication to my 3 1/2 old cat yesterday night and he vomited twice this morning. Not very much vomit, but I am wondering if I should worry. He seems fine otherwise and is eating normally. Some of the liquid dried on his fur when he jerked doing the application so I'm wondering if he was able to lick some off of himself. Should I wash off the dried up liquid on his fur? Thank you.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
Cats licking the site of application or fur where any product was spilled is a common cause of vomiting after administration; the product in contact with the skin would be absorbed by now so bathing Winter will not cause any issues with the application of the product. Monitor Winter for the time being; but if the vomiting continues, you notice tremors or any other worrying symptom you should visit your Veterinarian immediately. Regards Dr Callum Turner DVM

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Misty
moggy
16 Weeks
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Diarrhea
Lethargy
Bloating
Unbalanced

Hi,
We have a 16 week old kitten and applied advantage on advice about a week ago. She is now very lethargic, has diarrhea and is quite off balance. She also has a very bloated belly that sounds very upset, but still seems happy to eat/drink. Is this potentially a reaction to this medication, or should I be worried about something else. We have 2 other older cats that are fine.

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
It seems unlikely that her behavior is related to the Advantage that you applied, as most reactions to that medication are soon afterwards, and usually skin related. Since she is having these problems, it would be a good idea to have her seen by a veterinarian, as she may have parasites or another intestinal condition that needs to be treated. I hope that all goes well for her.

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Hansel
Himalayan
15 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Raw spots
Bald spots
sore spots
allergy?

I have used Advantage for many years on my 15 year old Himalayan Persian cat. No other flea medicine has ever worked. But, the last time I used it, he developed a bald, raw spot, right where I put it and about the same size as the wet spot from it. Also, two other small spots nearby. He has never had this before. It scabbed up and I removed the scabs and put Bacatraycin on it. It's been very slowly healing, but still bald.
My questions are: Should I remove scabs after they are dry? Will the fur grow back?
But mostly, can I try putting Advantage on him again? I need to keep him flea free as they attack him so badly now that is old and he picks them up so easily on the daily walks he insists we take him on. Is he now allergic to Advantage when he wasn't before?

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
If there was a reaction, I would normally recommend a different product to try to see if there is another reaction; you shouldn’t pick the scabs off, the sore will heal and the scab will fall off itself. You could try applying the product in a slightly different area (still where he cannot lick it) but there is a chance the reaction may recur. Regards Dr Callum Turner DVM

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Babe
Unkown
10 Weeks
Mild condition
0 found helpful
Mild condition

Has Symptoms

Diarrhea

I gave my 6 LB cat/kitten (10 weeks old) some Bayer Advantage II Flea Prevention Large Cats, over 9 lbs. I only intended to give her half of the tube but it poured out and i think i gave her too much. Also, I put it on the back of her neck but she was able to lick it. Not even two hours later she had violent diarrhea and its not one day later and she still has it. Should I take her to the vet? Is she going to die? She is still eating and drinking fine and acting fine. Please help.

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
Thank you for your email. One of the worrisome side effects from an over dosage of flea medication is seizures and tremors, which it does not sound like Babe is having. Since she is eating an drinking and bright and happy, the diarrhea may resolve. If she still has it tomorrow, or she stops eating or starts vomiting, then it would be best to have her seen by your veterinarian.

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Manny
Maine Coon/Tabby
3 Years
Fair condition
0 found helpful
Fair condition

Has Symptoms

Kitty zoom

I just put flea medicine on my cat and he’s darting across the living room back and forth. If I put the flea medication a little higher than the shoulder blades is that going to cause nerve damage?

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
Thank you for your email. Manny may just be having a local reaction to the flea medication. Location of administration should not matter with topical flea medications, but they can sometimes be irritating to the skin. If he shows any signs of tremoring, seizures, vomiting, diarrhea, or lethargy, he should be seen by your veterinarian to make sure that he is okay. If he is still agitated tomorrow, he should probably be seen, as well.

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Hannah
Cat
7 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

constant licking, biting of skin

My cat has fleas. I use advantage flea medication but I notice that she licks herself (all over) until her hair comes off and she has open areas on her body now. Is this an allergy to the medication or is it something else? Before getting the flea medicine, the doctor told me she was allergic to fleas so that is when I started to use advantage.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
If you are suspecting that Hannah has an allergy to Advantage, there are other flea control products on the market which you can try to use (Frontline, oral products etc...); speak with your Veterinarian about another product to try to see if there is any improvement in licking, also ensure that you are applying the product in the correct area. Regards Dr Callum Turner DVM

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Tilly
domestic short hair
2 Years
Fair condition
0 found helpful
Fair condition

I applied flea and tick medicine to the back of my cats neck, and i thought she wouldnt be able to reach it. Now shes drooling a little bit and jist laying down in her litter. (I just cleaned it out) should i wash it off her and try something else,or is this normal for cats? I dont have a cone or anything to put around her and im worried she might lick herself and get sick.? What should i do

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
Thank you for cocntacting us about Tilly. Topical flea prevention isn't typically toxic if ingested, it just tastes bad and might cause mild GI signs, vomiting and diarrhea. If she starts vomiting, has diarrhea, or doesn't want to eat over the next 24 hours, she should see her veterinarian. If you think that she might continue to lick at that area, it wold be best to wash offf the product, and call you veterinarian to get an oral form of flea control. I hope that all goes well for tilly!

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Bella
Maine Coon
8 Years
Serious condition
0 found helpful
Serious condition

Has Symptoms

Odor
Weight Loss
Lethargy
Vomiting
Drooling
Loss of Appetite
Dehydrated
ulcers

I believe my cat Bella had a horrible allergic reaction to Advantage II and she was misdiagnosed by the emergency room veterinarian. Here are the details:

Bella had many of the symptoms of an allergic reaction to Advantage; lethargy, vomiting, dehydration, failure to eat or drink, excessive drooling and foul breath. I contacted the 800 number on the Advantage box and was told she probably licked and ingested some of the Advantage, but the symptoms should go away within a short period of time.

Unfortunately, the symptoms became worse, so I took Bella to the emergency room with the box of Advantage. I was certain Bella had a severe allergic reaction to it. The doctor discovered ulcers on Bella’s tongue, gums and the roof of her mouth. The doctor said the wounds in her mouth were consistent with an "electrical cord bite." I was stunned.

I adopted Bella from a shelter six years ago when she was about three years old. In six years, not ONCE did she have any interest in electrical cords, let alone bite one. It might have LOOKED like an electrical burn, but what are the odds that Bella burned her mouth on an electrical cord, the exact same day I gave her Advantage for the first time?

I insisted it wasn’t an electrocution, but the doctor insisted it was. She gave Bella an injection of Cefovecin and a dose of Buprenorphine. I was given SQ fluids (prescribed 100 ml/day), additional Buprenorphine, and Sucralfate to administer at home. That’s it! The doctor also failed to hydrate Bella during her examination.

When I returned home, I read the medical info about Sucralfate and I still have no idea why it was prescribed for ulcers in the mouth. I also looked at every electrical cord in Bella's room and not one of them had bite marks.

The next day I contacted a home health doctor for a second opinion. He came to my home and immediately agreed with me. He diagnosed a “chemical burn” in Bella’s mouth; the result of a severe allergic reaction to licking the Advantage. Bella was also severely dehydrated (5+ %). The doctor had to administer 400 ml of subcutaneous fluids! He also gave Bella a mix of Staydol, Baytril, Vetalog, Pepcid and Vitamin B-12 through the SQ IV. I gave Bella a bath and a saltwater mouthwash, which I squirted around her gums and tongue with a syringe.

Shortly after the doctor left my home, Bella was sipping water for the first time in two days. She also began to purr!

As of this morning, Bella is so much better. She still won’t eat anything, but she did sip on some chicken broth. I also noticed the tip of her tongue is already turning pink again and there is no more drooling or mouth odor. I will continue to administer the doctor’s prescriptions and give Bella SQ as needed.

I’m furious about the original misdiagnosis. I paid $250 for the emergency room visit and meds. Then I had to pay another $257 for the second opinion and treatment. I am curious to know if there are any other cases where a pet received chemical burns from a flea killing topical application? I also know hives are a side effect of Advantage. Is it possible for a pet to get hives in their mouth?

Thank you.

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
Thank you for contacting us about Bella - I"m sorry that she has had such a hard time, but am glad that she seems to be feeling better. I personally haven't seen actual chemical burns from that product, although I have seen skin irritations that seem to be related. Blisters would be more likely in the mouth, and while it is a very uncommon reaction to Advantage that I haven't heard of before, anything is possible, and she may have had a reaction to the medication, based on your veterinarian's opinion. I'm sorry that she went through all of that, and hope that she continues to improve.

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Bella
Mixed Russian Blue
8 Years
Mild condition
0 found helpful
Mild condition

Has Symptoms

Itching, redness

y cat had an allergic reaction (redness, itching, sores on neck) to a %Seresto Flea collar by Bayer. The active ingredients in the collar are Flumethrin 4.5% and Imidacloprid 10.0%. Is it safe to use Bayer Defense Care Flea Protection topical treatment, with the active ingredient of Imidacloprid 9.1% on her?

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
Firstly bathe Bella to remove any possible residue left from the flea collar; I would leave her without any flea treatment for a week or two before trying another flea control product. We do not know what the underlying cause of the allergic reaction was, whether it was due to the collar’s active ingredients or another constituent of the collar. I would try using a different active ingredient for the next flea treatment (like fipronil) to see if there is any reaction. Regards Dr Callum Turner DVM

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Delilah
Maine Coon
14 Weeks
Mild condition
-2 found helpful
Mild condition

Has Symptoms

Lathargic

Hi I gave my 14 week kitten a 4x advantage spot on flea treatment which the Breeder gave me & she has been extremely lathargic now for 2 days , sleeping all day and night only moving to eat & drink & to use the litter tray

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
I may not be sully understanding your post but did you put all four pipettes from the box on to Delilah? if so visit your Veterinarian or Emergency Veterinarian immediately as one pipette is one month’s treatment. With normal usage, lethargy may be a side effect of administration and it is usually a case that you need to wait for the medication to leave her system; for next month discuss an alternative with your Veterinarian. Regards Dr Callum Turner DVM

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Lobot
Mixed
9 Years
Moderate
Has Symptoms
Loss Of Balance
Lethargic, Lessened Appetite, Some Difficulty With
Actually this happened 2 times. I didnt figure out it might be a reaction until the second time. 1st she quit eating, got dehydrated(possibly from diarrhea? But she is a indoor/outdoor cat) and became super lethargic. She would go outside and never leave our porch. In addition when she came inside, she would go straight to the bedroom and sleep