High Levels of Blood Nitrogen Average Cost

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What is High Levels of Blood Nitrogen?

Your veterinarian may refer to high levels of blood nitrogen in your cat as azotemia or uremia. Both are serious symptoms of underlying conditions only a veterinary professional is qualified to treat. If you suspect your cat has excess nitrogenous waste in her blood, schedule an appointment with a veterinarian as soon as possible. 

Several compounds in your cat's blood may contain nitrogen, such as creatinine, urea, and other byproducts of protein digestion. Levels of nitrogen-containing substances in the blood that are too high may indicate excessive dietary intake of protein, dehydration, or abnormal kidney function. 

Symptoms of High Levels of Blood Nitrogen in Cats

Since blood circulates through and delivers nutrients to all parts of your cat's body, high levels of blood nitrogen can affect many systems and lead to some seemingly unrelated symptoms. Signs your cat may be suffering from azotemia or uremia include:

  • Dehydration
  • Nausea and vomiting
  • Breath that smells like urine
  • Excess salivation
  • Change in volume or frequency of urine output
  • Coat that has lost luster
  • Weakness, confusion or stupor

If you suspect your cat may be suffering from azotemia or uremia, seek veterinary attention immediately. These symptoms could be indicative of acute renal failure or a serious condition such as chronic kidney disease. 

Causes of High Levels of Blood Nitrogen in Cats

The most common cause of high levels of blood nitrogen in cats is abnormal kidney function. If the kidneys are unable to filter waste products from the urine, waste will be resorbed back into the bloodstream. The kidneys may also fail to produce hormones necessary for nitrogen excretion, leading to the buildup of these products in the blood.

A diet that is too high in protein or the overproduction of nitrogen-containing substances can also elevate levels of blood nitrogen in cats. Dehydration can cause nitrogenous waste products to concentrate in the blood, artificially elevating blood nitrogen. Symptoms of chronic renal disease or diabetes, such as excess urination, excessive thirst, or rapid weight loss can also lead to elevated nitrogen in the blood.

Diagnosis of High Levels of Blood Nitrogen in Cats

Diagnosis of high levels of blood nitrogen will begin with a thorough physical examination of your cat, including the collection of all relevant medical history. Urine and blood samples will be collected by your veterinarian in order to perform relevant tests, such as a urinalysis, a complete blood count, and a chemistry profile. These tests will show whether nitrogenous waste is being excreted efficiently by the kidneys. It can also show what kind of nitrogen is present in the blood so that your veterinarian can determine the cause of the azotemia or uremia. 

In addition to confirming the presence of nitrogen in your cat's blood, your veterinarian will determine the cause of this buildup. Imaging such as x-rays and ultrasonography, urine cultures and tissue biopsies may be performed in to rule out chronic kidney disease or acute renal failure. The specific gravity, or concentration of particles, in your cat's urine may be measured to determine whether dehydration or excessive urination (polyuria) are contributing to the concentration of waste products in your cat's blood.

Treatment of High Levels of Blood Nitrogen in Cats

Your veterinarian will target the cause of high nitrogen levels in your cat’s blood when determining her course of treatment. For end-stage chronic kidney disease, your veterinarian may recommend dialysis or a kidney transplant. Alternatively, lifestyle modifications may be recommended to ease pain and symptoms of kidney disease, including the discomfort that results from high levels of nitrogen in the blood. 

For acute kidney disease, your veterinarian may administer rehydration fluids or place a temporary feeding tube. A catheter may be placed to promote the excretion of nitrogenous waste as urea in the urine. Prompt treatment of acute renal failure may restore some or all kidney function.

Your cat's prognosis will also vary depending on the cause of her azotemia or uremia. Cats with high levels of blood nitrogen secondary to dehydration, for example, can expect a full recovery. Cats newly diagnosed with late-stage chronic kidney disease or acute renal failure will require aggressive treatment, lifestyle management, and ongoing veterinary supervision to prevent relapse. 

Recovery of High Levels of Blood Nitrogen in Cats

Cats diagnosed with chronic kidney disease or acute renal failure will require intensive management throughout life. Your veterinarian may prescribe changes to your cat's diet, limiting fluid intake, medication, and ongoing monitoring of urine output. It is recommended cats in early stages of kidney disease follow-up with a veterinarian two or three times per year without symptoms. Cats in the late stages of kidney disease should be examined by a veterinarian every one to two months.

High Levels of Blood Nitrogen Questions and Advice from Veterinary Professionals

16 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Famished...restless....high bun....

My kitties bun level is 60...although sdma, creatinine and glucose are normal...does this point to kidney issues or something else? For the last 3 weeks she has been just famished....eating twice what she normally does...and seemingly not her usual self...seems distressed...restless...thyroid values normal...has had heart murmur all her life...heart is enlarged because of it...going to get a utinalysis tomorrow....what is going on? Getting scared

Dr. Michele King, DVM
Dr. Michele King, DVM
1044 Recommendations
When we look at lab work, we look at the entire clinical picture, including any relevant history to try and give us an idea as to what might be going on. BUN by itself can be indicative of kidney disease, or bleeding into the intestines. Since I do not know more about Princess, I have a hard time commenting on what might be going on, but depending on her signs, an ultrasound might be a good idea. You can discuss that with your veterinarian at your recheck, as they are able to assess her more fully, and the results of the urinalysis will help point to any problems, as well. I hope that she is okay!

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14 Years
Fair condition
0 found helpful
Fair condition

Has Symptoms

No obvious symptoms

Medication Used


Our cat, Sheba, recently had a bout of pancreatitis, from which she has now recovered with the help of some antibiotics.

The vet took some blood and urine samples at the first visit, and some more at a subsequent visit. Nothing showed on their local tests of the blood so the 2nd sample was sent to a specialist laboratory.

Because she was drinking a lot of water when she was sick, and both the urine samples were coming back with low concentrations, they wanted to check her kidneys were ok.

The specialist's result came back with only an elevated BUN. All other markers (phosphorous, potassium, etc) came back normal.

Her drinking has returned to normal, and she isn't using her litter box as frequently.

Still, they believe she has CKD, and want to put her a special diet. Are they correct in their diagnosis? Could the high BUN be just a case of being dehydrated due to her pancreatitis?

Just to note, she was diagnosed with a malignant lung tumour last November. At the time we were feeding her a cat milk (no lactose), and we switched her to water only to remove carbs from her diet. She is on Redipred to reduce the symptoms of the tumour which was causing sneezing fits and coughing fits.

She was also diagnosed with hypertension at the recent vet visits. Is on half tablet of Amlodipine.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
2466 Recommendations
If there are concerns regarding whether or not there is kidney disease, you should speak with your Veterinarian about a SDMA test (if not already performed) which is a kidney specific biomarker which is more specific to kidney disease than BUN or creatinine. The interpretive summary in the second link below goes over the possible causes for an increase in BUN on page 2 of the document. Regards Dr Callum Turner DVM www.idexx.com/en/veterinary/reference-laboratories/sdma/ www.idexx.eu/globalassets/documents/parameters/8071-us-bun-interpretive-summary.pdf

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5 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Vomiting dehydration

Cat stopped eating and viminting undigested food. Bloods showed cret and urea. On iv fluids for 48 hr. Bloods recheckd and cret dropped but still elevated. Fluid 2 more days and renal diet. Worried on whether we are doing what right for Millie andhow long we could have her for.

Dr. Michele King, DVM
Dr. Michele King, DVM
1044 Recommendations
Thank you for your email. IV fluid therapy is the treatment of choice for kidney disease, and we typically to keep them on fluids until the values come down. If her values are improving, that is a positive sign. Your veterinarian can give you a better idea as to her long term prognosis based on how she is responding to therapy. I hope that she does well.

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Domestic short hair Tom
13 Years
Fair condition
1 found helpful
Fair condition

Has Symptoms


Medication Used

Caninsulin for diabetes

Hi, My 13 yr old cat (Smudge) was diagnosed with diabetes 2 yrs ago. Now his blood glucose levels are all stable on 1 unit of caninsulin twice a day and nothing has changed. He is on a low carbohydrate, high protein diet (felix as good as it looks and occasional home cooked chicken) however the vet is now saying his blood urea nitrogen levels are very high! Is this normal in diabetic cats as he is on a high protein diet at all times and very low carbohydrate? The vet suggested royal canin prescription renal diet which is actually full of sugar and high in carbohydrate which he does not need and will make his diabetes worse! I don't trust prescription diets at all and do believe it's a money making business as most vets are endorsed to sell these! I was making home made food for both of my cats which consisted of semi cooked chicken thighs with some bones left in (puréed so they don't Choke!) chicken liver, heart, egg yolk and some vitamins and minerals including taurine, vitamin B and E, omega fish oil and a bit of psyllium husk for fibre for easy digestion. Both of my cat including Smudge absolutely loved it and were thriving on it with lots of energy, shiney coat and everything. Unfortunately I had to resort back to felix as good as it looks for convenience as making cat food was too time consuming as it all needed to be carefully measured etc and I couldn't manage with full time work.

So my question is am I doing right with Smudge by keeping him on low carbohydrate, high fat/protein diet to control his diabetes and should I be worried about his high levels of blood urea nitrogen? Or is this normal in his case? Is it necessary for him to be on prescription food for renal/kidney disease? He seems healthy, drinks and eats normal, urinates normal. Plays as much as a 13 yr old cat will and affectionate as always. He has lost a bit of weight but so has his healthy twin brother but I think that is because I reduced their food intake to try and get them to lose weight for their health as they are indoor pets. So I will be increasing their food intake a bit and monitor.
Any advice will be very appreciated, thank you in advance.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
2466 Recommendations
It is important to look at both BUN and creatinine as a measure of renal health; the problem comes as the dietary management of renal disease and diabetes are opposite ends of the spectrum but very often the two conditions occur hand in hand with cats. A balanced approach needs to be taken with a low phosphorus high quality protein (protein from chicken, eggs, liver etc… instead of grains) but remaining low on carbohydrates; there is some debate about which way to go as far as dietary management, the severity of the BUN and any creatinine increases in the blood needs to be address whilst keeping the diabetes controlled. Regards Dr Callum Turner DVM

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