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- Rigid muscles at entrance site, which is typically a wound or bite mark
- Stiff jaw and neck muscles
- Uncoordinated gait
- Weakness
- Fever
- Pain during urination
- Mouth upright in a "grin"
- Constipation
- Hard, stiff tail
- Stiff ears that are continually erect
- Breathing problems
- Difficulty with eating
- Painful sensitivity to touch
- Difficulty in opening mouth
- Whole-body spasms triggered by a sudden noise or movement
- Drawn-back lips
- Whole-body paralysis
- Death
- Localized: Neurotoxins just affect the nerve cells in the area around the entrance site/wound
- Generalized: Neurotoxins enter the site and spread through the nerve cells throughout the body
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