Microsporidiosis Encephalitozoonosis Average Cost

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What are Microsporidiosis Encephalitozoonosis?

Encephalitozoonosis affects the cat’s lymphatic, gastrointestinal, ocular, brain, urinary tract, kidneys, liver, and biliary systems. Once the infestation affects the kitten’s or cat’s brain or kidneys, the vet may recommend having the pet humanely euthanized.

This parasite can be passed from cats to human owners. People who know their cat has been infected should be careful about handling the cat and its waste, especially if anyone in the family is immunosuppressed.

Microsporidiosis encephalitozoonosis is a parasitic infection caused by the parasite Encephalitozoon cuniculi, leading to infestation in several parts of the cat’s body. Once the cat has ingested this parasite, it may begin showing symptoms ranging from kidney issues, slow growth, depression and neurological issues. If the cat is still a kitten when it is infected, quick treatment is needed. Fortunately, this parasitic infection is relatively rare in the U.S., but if the cat has come from another country, its owners should be watchful.

Symptoms of Microsporidiosis Encephalitozoonosis in Cats

Kittens infected with Encephalitozoon cuniculi will have symptoms in most of their body systems:

  • Renal failure
  • Stunted growth
  • Loss of appetite and weight loss
  • Neurological issues
  • Thin, dull fur

In kittens, infection may become obvious a few weeks after birth. 

Older cats may be asymptomatic (showing no symptoms of infestation or illness), but if symptoms do manifest, they include:

  • Strange gait
  • Eye problems (cataracts, blindness and inflamed eyes that rapidly get worse)
  • Behaviorally aggressive (biting, hissing and yowling)
  • Depression
  • Walking in circles
  • Loss of control in limbs and muscles
  • Blepharospasm (severe, involuntary closing of the eyelids)
  • Convulsions
  • Paralysis

Causes of Microsporidiosis Encephalitozoonosis in Cats

E. cuniculi infection in cats can be caused by one of several factors:

  • Contact with wildlife that has been infested
  • Inflation or ingestion of parasitic spores
  • Coming into contact with spores found in the feces, mucus and urine of infected animals
  • Passed to unborn kittens by infected queen (mother cat)
  • Eating the infected tissues of rodents or rabbits
  • High humidity
  • Living in a crowded kennel or cattery
  • Though rare, this parasite and resulting infection can be spread through the cat’s body tissues after traumatic injury.

These spores can survive outside the cat’s body for months, making a deep cleaning and sterilization necessary to prevent infection.

Diagnosis of Microsporidiosis Encephalitozoonosis in Cats

The vet needs to conduct several complex tests to arrive at the correct diagnosis. Along with a complete physical and routine bloodwork, the vet will carry out a urinalysis, fecal analysis and further testing on the blood sample drawn from the cat. The testing will cover the serum biochemistry, ALP elevations, which tell the vet has too much protein in the cat’s system, and elevated ALT markers, which will indicate to the vet that the cat has experienced a liver injury because of the infestation.

The fecal analysis will have spores from the parasites, if the cat has truly been infected. The cat’s urine may have blood in it. The vet should run a test to check for this, as well as for too much protein. 

Another specialized test that could reveal the presence of encephalitozoonosis is a laboratory examination of some of the cat’s tissues (called a histopathology). The cat will test positive with this test depending on where the spores are in its body and how severely it has been infected. Depending on the remainder of the cat’s symptoms, the vet will need to run other tests of the cat’s cardiovascular, respiratory, ocular and liver systems.

Two additional tests include TEM and ELISA testing. A vet with specialized knowledge can run them. However, the tests are expensive and take a long time to provide results to the vet.

Treatment of Microsporidiosis Encephalitozoonosis in Cats

A lengthy course of treatment with antifungal medications will help to eradicate the E. cuniculi parasites and spores from the cat’s body. The drugs of choice include fenbendazole, oxibendazole, itraconazole and albendazole. Ideally, the cat should begin these medications before infestation travels to the cat’s kidneys or brain. If this happens, it is too late for treatment to be effective.

The cat should be treated as an inpatient in an animal hospital to ensure that all medications and courses of treatment are properly administered. During treatment, it should receive sufficient fluids to aid in its recovery.

While the cat is being treated in the hospital, the home, cattery, or shelter should be thoroughly cleaned with a solution of 70 percent ethanol, 10 percent formalin, hydrogen peroxide and 10 percent bleach to make sure that every last spore is killed and eliminated. Once the cat’s environment has been cleaned, the cat owner or shelter workers should ensure that re-infestation does not take place.

Recovery of Microsporidiosis Encephalitozoonosis in Cats

Recovery from an infection of E. cuniculi is possible if the infestation was caught soon enough. It’s vital that the cat finish taking the entire course of every medication prescribed so that every single microorganism will be killed. Treatment can take up to three months.

Once the cat has returned home, strong sanitary practices will be necessary. Keep the floors clean and wash the cat’s bedding and every blanket it normally uses.

As long as the infection was detected and diagnosed before reaching the cat’s kidneys and brain, the cat has a good chance of recovery, with the ability to resume its normal life.

If the cat has been allowed to run free and kill prey, the owner should train the cat to live indoors. Because so many wild animals carry the E. cuniculi parasite, reinfection is possible if the cat is allowed to go back outside.

Microsporidiosis Encephalitozoonosis Questions and Advice from Veterinary Professionals

16 Years
Critical condition
0 found helpful
Critical condition

Has Symptoms

Weight loss, blindness, circling

Medication Used

Prednisolone leukeran

I just lost a cat that had enteric lymphoma which we treated into remission but while she was imunosuppressed she got cataracts and tested positive for cuniculi. The vet gave her a short course of medicine to destroy it but she continued to lose weight, became blind and walked in circles. Was this due to e cuniculi in her brain? What could we have done? Are my other cats at risk?

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
When we think about Encephalitozoon cuniculi we think about rabbits, but this parasite may occur in cats, dogs and other animals especially when immunosuppressed; cataracts and uveitis may be seen with this parasite in cats however I cannot say what the cause of death was or if anything may have been done differently without performing a necropsy. Regards Dr Callum Turner DVM

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2 Years
Critical condition
0 found helpful
Critical condition

Has Symptoms

See above please

Vet not familiar with this in cats, rear legs very weak gives out after a few steps. Been aware there was a problem for 5 days, took her to vet 3 consecutive days and Vet adminstered tapeworm meds first day, ran blood work; 2nd day did X-ray to see if any blockage, 3rd day IV fluids and she urinated several time. Tests came back okay, no sign of stones, no sign of poison. Vet thinks something she ate...vague. Took her home and she urinated again but 4th day no urine nor bowel movement. Been doing all natural treatments, called vet and mentioned my opinion it was e.cuniculi based on near death experience with a dog chasing rabbits years ago, discovered finally by a vet in MX who knew right away by smelling dog hair that dog ran in open fields and asked the right questions. Cat Vet disregarded my evaluation on day one but is now looking into it, now that it might be very late in the game. Cat drinks milk and fed it some raw fish, she was hungry and ate but no BM, seemed to have trouble with head and swallowing, chewing or jaw. She’s a fighter, young about 2 yrs, and a hunter. Should I also start her on the Febendazole plus the three other meds mentioned all at the same time? Are these a package protocol or pick one for the duration?

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
A diagnosis of Encephalitozoon cuniculi is rare in cats and is something I haven’t seen before, however it is more common is some parts of the world than others. Treatment with fenbendazole alone may be tried but would need to be discussed with your Veterinarian; however treatment needs to start earlier the better. Regards Dr Callum Turner DVM

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