What are Toxoplasmosis?
While all warm-blooded animals can be intermediate hosts of this disease, only cats are definite hosts. This means that the parasite can only produce eggs while infecting a cat. The parasite multiplies in the intestines and produces millions of eggs which then exit the body in feces. These eggs begin to exit three to ten days after infection has occurred and continue to exit for another 10-14 days thereafter.
The single-celled parasite, Toxoplasma gondii (T. gondii), can cause infection in virtually all warm-blooded animals. This disease is referred to as toxoplasmosis. Though it is present in 20-60 percent of cats, it only manifests itself as a significant disease in rare cases. Cats with immune deficiencies (such as feline leukemia virus, feline immunodeficiency virus or feline infectious peritonitis) and young kittens are the most susceptible to toxoplasmosis.
Symptoms of Toxoplasmosis in Cats
The infection of T. gondii tends to affect many parts of the body including the neural system, the liver and the muscles of the cat. Possible symptoms are as follows:
- Vomiting and diarrhea
- Loss of appetite
- Difficulty eating
- Inflammation of the eye (both uveitis and retinitis)
- Abnormal pupils
- Personality changes
- Pressing head against the wall
- Ear twitching
- Loss of coordination
- Sensitive to touch
- Muscle pain
- Hepatitis (liver disease) causing jaundice
- Enlarged lymph nodes
Causes of Toxoplasmosis in Cats
To become infected and develop toxoplasmosis, the cat must come in contact with T. gondii or its eggs. The eggs can live for 18 months or longer in water or soil. Common causes of exposure include:
- Contact with parasite outdoors
- Eating of raw meats infected with T. gondii
- Hunting of small mammals
- A bite or scratch from an infected cat
- Drinking water contaminated by T. gondii
- Sharing a litter box with an infected cat
Diagnosis of Toxoplasmosis in Cats
Your veterinarian will need your cat’s complete medical history before attempting diagnosis. They will assess all symptoms present in the cat and compare them with signs of toxoplasmosis. Even though the parasite’s eggs are often present in the fecal matter, it is generally not tested due to results mimicking many other parasitic infections.
A lab test that will generally be performed measures the antibodies in the cat. IgG and IgM (immunoglobulin G and M) are both antibodies that form in the blood after infection from T. gondii. If many IgG antibodies are found, the cat has most likely developed immunity to the parasite. If many IgM antibodies are found, the cat is currently infected and is most likely dispelling eggs. If no antibodies are found, the cat is susceptible to infection but is not currently diseased.
Another test that might be performed is a microscopic examination of tissue impression smears (surface sample). These tests look for distinctive pathological changes and the beginnings of tachyzoite (one of three infectious stages of T. gondii) development.
Treatment of Toxoplasmosis in Cats
There currently is no cure for toxoplasmosis. Treatment is available to help slow down the process of infection and aid the cat in handling the stages of infection.
Different antibiotics can be prescribed to disable the progression of parasitic infection. Clindamycin is often prescribed to disseminate the T. gondii organisms. Pyrimethamine along with sulfadiazine or trimethoprim sulphonamide can be administered to stop reproduction of T. gondii. The antibiotics are given immediately and are taken until at least several symptom-free days have passed. If no improvement is seen in three days, rediagnosis may be necessary.
Most cats respond favorably to these treatments. Once again young cats and cats with immune suppression tend to fare worse.
Recovery of Toxoplasmosis in Cats
If you have other cats it is important to take precautions to ensure they also do not become infected. Clean the litter box carefully with scalding water on a daily basis. T. gondii requires one to five days once exited from the cat to become infectious, so daily removal of feces can prevent the spreading of the parasite. Thoroughly wash hands after removal of cat waste. Pregnant women or people undergoing chemotherapy treatment should not handle the litter box as they are vulnerable to toxoplasmosis development.
Keep your cats indoors to prevent contact with the parasite. Also, do not allow your cat to eat raw meats. T. gondii produces cysts in the animals it infects that can spread the disease if eaten.
Toxoplasmosis Questions and Advice from Veterinary Professionals
Hello! We have a stray kitty that we found on the street. She's been living with us for about 1.5 months. Last Thursday she started to behave disoriented and partially or completely blind. On Sunday at 1am she had seizure. We took her to Emergency Clinic. They Put her on Clindamycin and Keppra for seizure prevention. We picked her up this morning and took to a neurologist. She said doing MRI is waste of money and she would put the kitty down. The kitty is 3 months old. I wanted a second opinion, so we managed to get another appointment in different clinic. The neurologist didn't tell us to necessary put her down. He told us that we can keep going with Clindomycin for another 2-3 weeks. But he said that since kitty is that young, chances are next to none. And none of them knows the exact cause of blindness or seizure. Kitty has good appetite, and can walk. But doesn't recognize me or my wife anymore and avoids contact, especially when somebody tries to touch her head. Doctors stated that she hissed when they tried to touch her. However, I think she tried to defend herself, since she's been to 3 hospitals and dozen of doctors/nurses in 2 days. She is not aggressive at home but she still look disoriented . Another vet suggested Albon could help her brain too.
I want to give this little one a chance, since she's been through a lot already(burnt paws, prolapsed rectum). We keep her isolated in a cage in a separate room, since we have 2 of our own cats. Would you give her time to try to fight whatever her disease is? Is it still worth spending a lot of money on MRI?
P.S. Looks like her vision got better, she reacts to movement sometimes
Kitty has whip worms and was prescribed Panacur
Please follow up with this thread. Your kittens symptoms sound a lot like my stray kitten. He was diagnosed with Toxoplasmosis from displaying fever of unknown origin, lethargy, not eating, etc. Had blood work to rule out FIP and they called and said Toxoplasmosis and gave me Clindamycin and said give it to him and his sister for four weeks. He has been on it a week and seemed a little better but not by much. I am sure he had two seizures today. The first one I thought someone scared him but the second time he flopped around and layer down like exhausted. What was your outcome. He has me scared and his Vet is not in. Emergency Vet (MedVets) is an hour away.
Thank you for your advice! She started to feel better today. She meowed for the first time, since she went blind, she recognizes us, she tries to get out from the cage and wants us to pet her. Yesterday she didn't let anybody to touch her, especially her head. We set up an appointment with another neurologist in our area, since kitty is showing signs of progress.
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I have been treating my 7 month old kitten for what we believe is toxoplasmosis for 2 weeks. She was losing the ability to walk properly and was very dizzy. She is walking a bit better so the vet recommended another 2 weeks of medication but she is still constantly under the bed and walking weak. How long until her symptoms will completely clear? Also I have 2 full grown male cats aswell, if they had been exposed would I have seen symptoms in them by now or do I need to take them to the vet to be sure?
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Can toxoplasmosis in my cat present with symptoms similar to cerebellar hypoplasia? He was diagnosed with CH at about 9 weeks of age and within the last 3 weeks his symptoms have worsened. I understand that CH is not a progressive condition.
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