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- Lump under the skin where injection occurred, which may be growing
- Lump that develops weeks after injection and does not dissipate
- Swelling around the tumor
- Skin ulceration at the site of the tumor
- Limping or leg tenderness if tumor located on a limb
- Loss of appetite
- Weight loss
- Lethargy
- Adjuvants (especially those containing aluminum)
- The process of under-skin injection itself
- Frequency of vaccinations
- Inflammatory response of the cat
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