Indomethacin Toxicity in Dogs

Indomethacin Toxicity in Dogs - Symptoms, Causes, Diagnosis, Treatment, Recovery, Management, Cost

What is Indomethacin Toxicity?

Indomethacin is a type of NSAID in human medicine.  It is not recommended for dogs as it causes severe issues, especially within the gastrointestinal tract.  Symptoms of toxicity can range from drowsiness, abdominal pain and depression to weakness, gastritis and hematemesis (vomiting of blood).  Treatment is symptomatic in accordance with the severity of your dog’s symptoms.  His prognosis of recovery will depend on the extent of damage within his gastrointestinal tract.

Indomethacin toxicity can severely affect your dog.  If you believe or know he ingested this medication, take him to his veterinarian immediately.

Symptoms of Indomethacin Toxicity in Dogs

Symptoms of indomethacin toxicity may include:

  • Depression
  • Anorexia
  • Melena¬†
  • Hematemesis¬†
  • Abdominal pain
  • Gastritis¬†
  • Vomiting¬†
  • Weight loss¬†
  • Pale mucous membranes
  • Weakness
  • Lethargy
  • Drowsiness¬†


Indomethacin is a type of nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation in the body.  It is a prescription medication for humans, not for dogs; if your dog ingests this medication, it is potentially toxic.  Indomethacin is a derivative of acetic acid and you can expect your dog to manifest adverse effects from ingestion of the medication.

Causes of Indomethacin Toxicity in Dogs

In dogs, indomethacin is absorbed rapidly.  It is metabolized in the liver and excreted in the urine.  A very small amount of medication can cause your dog to experience an adverse reaction.  Your veterinarian will not prescribe your dog this medication; if he somehow ingests it, it is may be due to him possibly finding it himself and accidentally eating it without knowing any better.

Diagnosis of Indomethacin Toxicity in Dogs

Your veterinarian will begin by performing a full physical exam on your dog.  While doing this, she will also want to collect a verbal history from you.  She will want to know any and all details in regards to his condition.  She will want to know when his symptoms started, if they have progressed and if so how quickly, if you witnessed him ingesting anything or if suspect he did, if he is taking medications or if you administered any to him, or anything else helpful in regards to his situation.    

If you suspect your dog got into some type of medication he should not have, be sure to bring in the medication with you.  This will allow your veterinarian to have in front of her exactly what he ingested, the dosage and possibly how many pills.  Having an idea of what medication your dog may have ingested will help the veterinarian with her treatment plan. 

If your veterinarian is unsure of what is causing your dog’s symptoms, she will begin her diagnosis with blood work and additional lab work.  In regards to blood work, a complete blood count (CBC) and chemistry panel will provide your veterinarian with general information on how his organs are functioning and his blood chemistry levels and its productivity.  This blood work will show if your dog is experiencing any type of organ system failure.  Many dogs that ingest indomethacin develop renal failure.  Additionally, a urine sample may be collected for a urinalysis; this will give information on the health of your dog’s kidneys and bladder.  

In order to diagnose and properly view the degree of gastric irritation, your veterinarian may employ diagnostic imaging.  If practiced with an ultrasound she may utilize it to view the gastrointestinal tract for any abnormalities and how it is flowing.  Other imaging will include radiographs with barium contrast.  This will show where the abnormalities are and how deep the ulcerations go within the tract. Endoscopy is also a good imaging option to view how extensive the damage to the digestive tract is.  

If your veterinarian needs further diagnostics, she will perform them based on your dog’s symptoms.

Treatment of Indomethacin Toxicity in Dogs

If your dog is, in fact, experiencing toxicity from ingesting indomethacin, the sooner he receives treatment the better.  Decontamination is ideal in cases of toxicity, especially in cases where the medication can cause severe gastrointestinal ulceration.  If it has not been too long, the veterinarian may attempt to induce vomiting to expel the drugs from your dog’s stomach before they are absorbed further.  If this is unsuccessful, she may choose to administer activated charcoal or some other form of absorbent to make the drug bind for removal from his system.  She may also administer a medication such as sucralfate which works by binding to and coating ulcers within the GI tract.  This will prevent further damage to the intestinal tract.

Your dog will likely need to be hospitalized as he will need supportive care until the drugs leave his system completely.  He will be kept for treatments and monitoring by the veterinarian and her staff.  An intravenous catheter will be placed in one of his front legs as soon as possible in order to begin administration of intravenous fluids.  The fluids will correct any degree of dehydration your dog is experiencing as well as correct any electrolyte imbalances.  The fluids will also support renal function and flush the toxin from his system quicker.  

Medications will be administered depending on what symptoms your dog is experiencing.  Additional therapies will be included as needed by your dog.  If he is vomiting, an anti-nausea medication will be administered; if he is having diarrhea, a medication will be give in an attempt to help soothe his digestive tract.  Whatever his needs, your veterinarian will be able to provide for them in the best way possible.

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Recovery of Indomethacin Toxicity in Dogs

The time of duration between ingestion and therapy will affect your dog’s prognosis of recovery.  If not treated promptly and properly, your dog has a poor prognosis at a good recovery.  Once the GI tract is damaged, it can make eating painful, certain exercise painful and other actions of everyday life more agonizing.  The best thing you can do for your dog is prevent him from ingesting this medication in the first place.

Indomethacin Toxicity Questions and Advice from Veterinary Professionals


Staffordshire Bull Terrier



Five Years


0 found this helpful


0 found this helpful

My pet has the following symptoms:
None Presently
I gave my dog one capsule of indomethacin. He was limping pretty bad after the dog park, and I wanted to ease his pain. About 2 years ago, the vet said he may have slipped a disk, and he has never been the same. Drags his back feet after about 10 min walking. At first he was completely dragging both back legs, but get better over time. But never back to 100%. Will this one capsule of this nsaid hurt him? I gave it to him before I read about it not being good:(

July 18, 2020

Answered by Jessica N. DVM

0 Recommendations

Hello- Thank you for reaching out. For potential toxin ingestion my first recommendation would be to call pet poison helpline at 855-764-7661. They will be able to tell you based on the amount of medication he received if it is toxic and can make a treatment plan for your veterinarian. I would also recommend seeing a veterinarian immediately.

July 18, 2020

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