Maldigestion Disorder in Dogs

Maldigestion Disorder in Dogs - Symptoms, Causes, Diagnosis, Treatment, Recovery, Management, Cost

What is Maldigestion Disorder?

Maldigestion disorder in dogs, a condition also known as exocrine pancreatic insufficiency (EPI), is a relatively common disorder in canines.  The associated malabsorption of nutrients causes a loss in body condition of the host while the canine continues to remain hungry and eats ravenously.  

While this condition can occur in any canine breed, it is more common in German Shepherds, Collie breeds and English Setters and is believed to be genetic in nature.  The condition is treatable.

Maldigestion disorder, also known as exocrine pancreatic insufficiency (EPI), is defined as reduced secretion of pancreatic digestive enzymes by the exocrine portion of the pancreas into the intestines, reducing the appropriate digestion and absorption of food.

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Symptoms of Maldigestion Disorder in Dogs

As noted above, dogs afflicted with maldigestion disorder or exocrine pancreatic insufficiency cannot digest foods because they lack certain enzymes.  Here are some of the symptoms you would likely notice in your canine family member:

  • Diarrhea - often foul smelling
  • Fatigue
  • Flatulence (gas)
  • Increased appetite
  • Weight loss
  • Poor hair coat
  • Undigested fat in stools
  • Color and consistency of feces - usually an oily yellow-gray consistency


While there are a variety of malabsorption syndromes in small animals, maldigestion disorder or exocrine pancreatic insufficiency has two types.  

  • Inherited - The genes are a gift from their parents; the condition usually begins to show up between 1 and 4 years of age
  • Grumbling pancreatitis - Results from low grade, long-term pancreatic inflammation and usually shows up in older dogs ranging from approximately 4 to 8 years of age

As noted above, this condition can affect any canine breed but is more commonly found in German Shepherds, Collie breeds and English Setters and is believed to have a genetic basis with no gender predisposition.  The cause for EPI is the same in both types.

Causes of Maldigestion Disorder in Dogs

The cause of maldigestion disorder in dogs, as well as exocrine pancreatic insufficiency, is the lack of certain digestive enzymes secreted by the pancreas into the intestinal system where they are needed to properly digest food and absorb the needed nutrients.  The lack of these certain digestive enzymes is caused by damage to certain types of pancreatic cells, reducing their ability to manufacture the required digestive enzymes.  Certain enzymes responsible for controlling digestion of the various categories of nutrients in foods are:

  • Lipase - An enzyme which controls the digestion of fats  
  • Amylase - An enzyme which controls the digestion of starches
  • Trypsin and Chymotrypsin - Enzymes which control the digestion of proteins

If any of these enzymes are missing in your pet’s gut, then there will be undigested remains in the feces of the host.

Diagnosis of Maldigestion Disorder in Dogs

In order to arrive at an accurate diagnosis, your veterinary professional will need a good, thorough history from you.  This history should include:

  • Dietary regimen (food offered, snacks offered, frequency of feeding, amounts of feeding)
  • Report any changes in appetite and eating behaviors and duration of those changes
  • List the symptoms noted along with their severity and duration 
  • Health history and vaccinations if not readily available to your current treating vet
  • Any changes noted in the activity/energy levels of your pet. 

Your vet will do a physical examination and will order blood, urine and fecal sample testing.  There are many other health conditions and diseases which can have similar symptoms and your vet will need to rule them out to isolate the root or underlying cause. In this vein, he may wish to get imaging studies like radiography (x-rays), CT or MRI imaging to rule out other possible causes of the symptoms of which your canine family member is suffering.  Once he has collected and analyzed the results of his exam, your history and the testing modalities he has ordered, an appropriate treatment plan will be developed and initiated.

Treatment of Maldigestion Disorder in Dogs

The treatment plan will likely consist of a multi-level approach which will include:

  • Need to address the actual enzymes identified as missing in your pet’s digestive process 
  • Dietary changes which will include the type of food being given to your pet 
  • Perhaps the frequency of feeding that food.  

Once the missing enzymes have been identified, replacement of those missing enzymes will need to be implemented.  This can be done with a supplement which is available as powder, capsule and tablet forms.  Mixing the supplement with the food is the best way to get it into your pet’s system - this makes the powder the most convenient but the tablets can also be crushed and mixed with the food and the capsules can be opened and the contents sprinkled into the food - your vet will advise you of the appropriate dosing and method of infusing it into the dietary regimen.

An appropriate food will be recommended to be fed. This dietary change will be based upon the enzyme and the nutrient type which is not being digested; you might have to change to a low fat, or a low carb, or a lower fiber diet for example.

Smaller and more frequent meals may be required to ease the load on the digestive system and to get the supplements into the system more efficiently. For example, you might have to feed your pet three times a day instead of once a day, being sure to include the supplement with each meal.

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Recovery of Maldigestion Disorder in Dogs

Recovery and prognosis for your pet diagnosed with and suffering from maldigestion disorder in dogs is generally good if the condition is identified and treated appropriately and in a timely manner.  The vet will be concerned about improving the malnutrition condition of your pet, bringing him back to a relatively normal level of nutritional health.  This will likely be done with dietary changes, the addition of enzyme supplementation and home routine changes.  

Over time, your pet’s condition should improve and you should begin to see a healthier version of your doggy family member return to you. Be prepared for the supplementation of the pancreatic digestive enzymes and the dietary changes to become a “new normal” for your pet for the rest of his life.

Maldigestion Disorder Questions and Advice from Veterinary Professionals


Golden Retriever




Two Years


1 found this helpful


1 found this helpful

My pet has the following symptoms:
Loose Stool
I rescued a 2 year old, 43 pound (needs 2-3 more pounds, she is very petite), female golden retriever from a "breeder" on June 1. She had soft stools or diarrhea (but no urgency). One week later, we saw our vet and had a diagnosis of whipworm. She immediately took three days of Panacur, got her Interceptor for the month, and then got spayed on the 4th day (so fasted). There was hope after her spay, her stools looked slightly more firm after not having had food in her belly for 24 hours - at least they weren't leaving streaks on the grass if I picked it up correctly. Since then, her stool has been soft or really soft, but not heading in the firm direction. We had a perscription of Metronidazol for 7 days somewhere in there... about 2-3 weeks ago. On July 1, she got her second Interceptor treatment. Six weeks in to living with me, she got urgent diarrhea suddenly. The vet retested her stool and found no whipworm, but we did a course of Panacur anyway (there was mucus and blood in the stool). They allowed me to give her an immodium tablet to stop the urgent diarrhea and it did the trick. We also started 1/4 tsp of Tylan Powder with both meals for the next month. Almost a week later, I'm adding her salmon and sweet potato kibble food back into her bland diet of I/D canned (or chicken and rice), and her stools at least have form to them but are pretty soft. I'm really at a loss. Her sister was rescued at the same time and lives one house away. She is having the same problems with her stool and developed urgent diarrhea yesterday. They were both whipworm positive when picked up. So far, we've been on Tylan powder since Wednesday evening, and it hasn't done anything miracle-like. I would imagine that her breeder's property is infested with whipworm (I did not see it, but I notified her after the diagnosis) and she's had it from the start. Could a long-term infection of whipworms cause a long recovery for her colon? Could she and her sister developed something else from the whipworm infection? What else should we be considering as a problem for her. My online research has yielded very little. Maldigestion? IBS? Dybiosis? I should add that Maizey has been a fireball since she settled in and became comfortable with being in a house. She eats ravenously, sniffs/rolls around on the ground a LOT, and does zoomies in the yard frequently. Eyes are clear and gums are pink. She is otherwise a very normal dog

July 15, 2018

1 Recommendations

There are many causes for loose stools in dogs with infections, parasites, diet, stress, colitis (and associated conditions) among other causes; it is possible that the gastrointestinal tract is inflamed from a long term whipworm infection and sometimes whipworms may not show up on a faecal floatation test since they don’t continually shed eggs. I would continue with the diet for now and monitor for signs of improvement as well as doing another faecal floatation test after a month to be on the safe side (possible false negative). Regards Dr Callum Turner DVM

July 16, 2018

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Belgian Malinois




3 Years


0 found this helpful


0 found this helpful

My pet has the following symptoms:
Weight Loss
Yellow Loose Stool
My 3 year old female Belgian Malinois is losing weight although she has probably doubled her food intake. She has never had any health issues what so ever but has contracted loose yellow to gray stool for about a month now. Energy level is still normal. All this seemed to start after a Lepto vaccine although my vet claims these are not side effects of Lepto vaccination. I disagree and have found numerous forums where people claim the same side effects from Lepto. Fecal samples have been conducted to rule out parasites along with a series of Flagyl to rule out intestinal infection. I'm running out of ideas.

June 24, 2018

0 Recommendations

There is a lot of negative press online regarding the Nobivac L4 vaccine (and others) and I will not get into details; however a lot of the information online from mainstream media and from forums is misleading and misses out a lot of the facts and statistics (i.e: the actual low number of adverse reactions in relation to the high numbers of doses given each year). I cannot confirm that the symptoms Kiska is suffering from are related to the vaccination as they don’t directly correlate with published data. Regards Dr Callum Turner DVM (adverse reaction information on page 3)

June 25, 2018

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