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What is Milkweed Poisoning?

Plants in the Asclepias genus, more commonly known as milkweed plants, are herbaceous perennials with complex flowers. Plants in the Asclepias genus contain several toxins throughout the plant, including galitoxin and cardiac glycosides. These compounds can make the consumption of milkweed plants toxic in moderate to large amounts.Certain insects have developed to dine on the milkweed plant, most notably the caterpillar of the monarch butterfly. The constant ingestion of milkweed sap during the caterpillar stage can also make both the caterpillar and subsequent butterfly noxious as well.

Milkweed plants contain both galitoxin and cardiac glycosides in all parts of the plant, although they concentrate in the sap. Ingestion of milkweed should be treated as an urgent matter.

Milkweed Poisoning Average Cost

From 493 quotes ranging from $800 - $200

Average Cost

$400

Symptoms of Milkweed Poisoning in Dogs

The symptoms of milkweed poisoning are caused by a combination of galitoxin and cardiac glycosides. If you suspect that your pet has eaten milkweed, contact your veterinarian as soon as possible for a definitive diagnosis and treatment plan. 

  • Cardiac arrhythmias
  • Collapse
  • Decreased heart rate
  • Depression
  • Diarrhea
  • Drooling
  • Hyperkalemia (high levels of potassium in blood)
  • Increased heart rate
  • Loss of appetite
  • Lethargy
  • Nausea
  • Nervousness
  • Seizures
  • Sudden death
  • Tremors
  • Unsteady gait
  • Vomiting
  • Weakness

Types

There are many species of milkweed, known by names as diverse as butterfly weed, blood flower, and pleurisy root. Although all plants in the Asclepias genus are toxic, the levels of toxic compounds in each plant can be quite different from one species to another. The species that display narrow leaves are much more likely to cause neurotoxic symptoms to develop, whereas the broader leaved varieties tend to induce the cardiac related signs and symptoms. Some examples of species with narrow leaves would include the Asclepias verticillata, or whorled milkweed and the Asclepias linaria, or pine needle milkweed. Asclepias erosa, also known as desert milkweed, and Asclepias cordifolia, known as heart-leaf milkweed, would be considered broad-leaved species.

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Causes of Milkweed Poisoning in Dogs

The primary toxin in milkweed is galitoxin, which is responsible for most of the tremors, nervousness, and seizures.The milkweed plant also has high concentrations of cardiac glycosides in its sap. These organic compounds are known to alter the rhythm of the heart by acting on the force of the cardiac muscle itself. Cardiac glycosides have been for centuries both as a treatment method for those with certain cardiac disorders and as a potent poison.

In addition, the caterpillar of the monarch butterfly dines exclusively on the sap of the milkweed plant, rendering both the caterpillar and butterfly mildly toxic as well.

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Diagnosis of Milkweed Poisoning in Dogs

If you catch your pet consuming milkweed plant, signs of intoxication combined with the identification of the plant should be enough to make a preliminary diagnosis. Your veterinarian will ask for more information about how much the patient ingested and how long ago the ingestion occurred. If consumption of the item was not witnessed, symptoms would be likely to prompt questions regarding any opportunistic eating that was witnessed or suspected in addition to any prescribed prescriptions or dietary supplements that have been administered to your dog. Other medications are particularly important when dealing with milkweed toxicity as drugs such as beta-blockers, steroids, and some chemotherapy agents may have negative interactions with cardiac glycosides. A biochemistry profile is likely at this time, as well as a complete blood count and urinalysis. The levels of magnesium and potassium that are present in the blood will be expressly noted. There are blood tests available to detect the presence and amount of the cardiac glycosides in the circulatory system. The cost of these methods, unfortunately, limits their accessibility for veterinary diagnosis.

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Treatment of Milkweed Poisoning in Dogs

If it has been just a short time since ingestion, your veterinarian may instruct you on the proper method to induce vomiting in your dog. If your pet is still conscious when you reach your veterinarian's office, and not actively vomiting, activated charcoal is likely to be administered in an attempt to soak up as many of the toxins as possible before they disperse into the bloodstream. Some cases of poisoning with cardiac glycosides will require that your pet undergoes a gastric lavage. Supportive measures for poisonings will usually include IV fluids for dehydration and combinations of sugars and electrolytes to adjust for any imbalances. Calcium is known to enhance the effects of cardiac glycoside so should be avoided as an additive to the IV fluids. Supplemental potassium can also be risky as it has been known to induce hyperkalemia. Antiarrhythmic drugs such as atropine sulfate, lidocaine, or procainamide may be utilized to regulate the heart. Although digoxin-specific antibodies have had some success in treating toxicity in humans, it has not proven as effective in other animals such as canines and is rarely recommended. Experimental treatments using injections of fructose have also been completed to reduce serum potassium levels and heart irregularities.

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Recovery of Milkweed Poisoning in Dogs

The patient usually succumbs or begins the recovery process within 24 hours from the emergence of the first symptoms, and supportive measures are a key factor in mortality. Ensuring that a quiet and calm setting for the recuperating patient to return home to will help speed recovery. This is of particular importance when cardiac glycoside poisoning is involved to avoid further stress on the heart. Ample quantities of fresh water should be made available to avoid dehydration Canines recovering from anesthesia such as given for a gastric irrigation may have coordination difficulties at first, and are often initially confused and disoriented. Isolation from children and other pets may be advised until the medication has fully cleared your companion’s system.

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Milkweed Poisoning Average Cost

From 493 quotes ranging from $800 - $200

Average Cost

$400

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Milkweed Poisoning Questions and Advice from Veterinary Professionals

Need pet health advice? Ask a vet

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Ask a Vet

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Beagle/Sheba emu mix

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Three Years

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Unknown severity

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0 found helpful

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Unknown severity

Has Symptoms

Vomiting, Loss Of Appetite

My dog ate butterfly wings. Should I do anything? She vomited once and didn't eat.

Aug. 2, 2020

Owner

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Dr. Michele K. DVM

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0 Recommendations

Thank you for your question. I cannot see the butterfly wings upsetting her stomach, and I suspect that she may have eaten something else, or there may be something else going on. If she continues to vomit and not eat, it would be best to have her seen by a veterinarian, as they can examine her and see what might be causing this. They will be able to let you know more what is going on, and what treatments you might need. I hope she feels better soon.

Aug. 2, 2020

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Chihuahua

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Eight Months

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Unknown severity

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0 found helpful

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Unknown severity

Has Symptoms

Vomiting

My dog ate a little milkweed and vomited you the leaves. She just vomited again but it was all liquid. Does this mean she got it all out of her belly?

July 23, 2020

Owner

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Jessica N. DVM

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0 Recommendations

Hello- Honestly it’s very hard to say whether or not she has vomited all she has consumed. For potential toxin ingestion my first recommendation would be to call pet poison helpline at 855-764-7661. They will be able to tell you based on the amount of medication she received if it is toxic and can make a treatment plan for your veterinarian. I would also recommend seeing your veterinarian immediately. I hope she feels better soon.

July 23, 2020

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Poppy

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Labrador Retriever

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8 Months

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Critical severity

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Critical severity

Has Symptoms

Vomiting

Our 8 month old Labrador Retriever puppy ingested half of a milkweed pod and within 12 hours was in emergency surgery. The morning after ingesting it, she woke up vomiting violently and continued to do so nonstop for over an hour until I took her to our vet who immediately decided to run labs and scans. When the scans and X-rays came back, they found seeds from the milkweed in her stomach, so surgery was called for immediately to save her life. It was an awful and frightening time. If you have dogs, PLEASE do yourselves a favor and get rid of any milkweed pods you find!!!

Sept. 7, 2018

Poppy's Owner

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Ozzie

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Jack Russell Terrier

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6 Years

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Fair severity

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Fair severity

Has Symptoms

Vomiting

We believe our dog ate a single monarch caterpillar. He vomited a couple times last night and a little this late morning. He is eating and drinking. Can we watchfully wait?

July 12, 2018

Ozzie's Owner


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3320 Recommendations

Since monarch caterpillars eat milkweed they contain a large concentration of cardiac glycosides which can be fatal in some cases; I cannot recommend that you just wait and see, you should visit your Veterinarian immediately for an examination and treatment. Regards Dr Callum Turner DVM

July 13, 2018

ANY updates on your dog?? Mine just ate a monarch also. I’m worried.

July 24, 2018

Elizabeth C.

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Remington

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Lab/Greyhound mix

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1 Year

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Fair severity

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Fair severity

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My dogs have found some dried pods from the milkweed plant. They normally just tear them up but the newest rescue may have eaten a bit of the fluff. Should I be worried? I'm not really sure if he swallowed any but thought it better to ask than just wait.

July 26, 2017

Remington's Owner


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3320 Recommendations

All parts of a milkweed plant are considered to be poisonous and contain compounds that affect the central nervous system and heart. I always recommend in cases of suspected poisoning visiting your Veterinarian for preventative care. Symptoms of poisoning include vomiting, tremors, seizures, abnormal heart rate, coma and death. Regards Dr Callum Turner DVM

July 26, 2017

AN UPDATE WOULD BE NICE

Feb. 21, 2018

Leah P.

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Princess

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Labrador Retriever

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15 Years

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Moderate severity

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Moderate severity

Has Symptoms

Diarrhea
Shaking
Dehydration
Panting
Vomit
Refuses Food
Shakey

We think she came across some Monarch Caterpillar Goo after one of our cats scared it into dying, tried it and decided it was gross, but shes been shaking and thirsty and won't leave behind house and won't eat and she already has so many topical skin allergies we are so scared for her health, but this is all happening during covid19 and no one has a job or money to get her help. I just want to know shes going to survive. She sleeps normal, a good 60-70% of the day, as a lazy lab will, but we dont know how to help her at home other than supply her fresh water whenever she needs.

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Blue

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Goldendoodle

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5 Months

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Moderate severity

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pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Moderate severity

Has Symptoms

Diarrhea
Blood In Stool
Foaming At The Mouth

Our 5 month old Goldendoodle puppy crunched on a milkweed clipping in the garden yesterday. He immediately began foaming at the mouth. He seemed fine the rest of the day, but suffered from severe diarrhea all night. He seems fine, but there was blood in the stools and we are taking him in to see the vet this morning.

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Daisy

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Golden Retriever

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6 Months

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Fair severity

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Fair severity

Has Symptoms

Vomiting

My 6 month golden retriever puppy quickly licked the end of a milkweed stem once. She threw up a tiny bit at first but has been fine since. She has eaten without any vomiting. Should we be worried?

Milkweed Poisoning Average Cost

From 493 quotes ranging from $800 - $200

Average Cost

$400