Neosporosis in Dogs

Some dogs with neosporosis can be carriers and have no symptoms at all but most have at least a few of these common signs:

• Dermatitis
• Ulcers in the skin
• Abortion in pregnant females
• Damage to the liver
• Respiratory infections such as bronchitis and pneumonia

If the infestation is severe, damage to the central nervous system can create complications such as:

• Walking in circles
• Abnormal behavior
• Slowed reflexes
• Confusion
• Weak muscles
• Muscle inflammation
• Trembling or shaking
• Vision trouble including blurriness or even blindness in severe cases
• Paralysis of the legs
• Difficulty swallowing
• Death

Types

• Neospora caninum is the most common type of neosporosis that affects many species such as dogs, horses, cattle, and sheep
• Neospora hughesi is a relatively new form of neosporosis that has only been known to affect horses so far

Those dogs with neosporosis can be definitively diagnosed by your description of symptoms and doing a group of serology tests to determine if your dog has neosporosis. First, a physical examination will be performed, including vital signs, reflexes, and skin assessment. A lameness examination, palpation, and auscultation will all be performed as well. Laboratory tests may include a polymerase chain reaction (PCR) test to check the DNA, antibody titer to look for antibodies with fluorescent stain, a complete blood count, and biochemical analysis.

The tests will likely indicate high aspartate aminotransferase (AST), creatine kinase (CK), alanine aminotransferase (ALT), protein, and alkaline phosphatase (ALP). Decreased eosinophils, neutrophils, macrophages, lymphocytes, and monocytes are also commonly found. In addition, several muscle tissue samples will be taken for microscopic evaluation.

Additionally, the veterinarian will most likely get some chest and abdominal radiographs (x-rays) to check the lungs for infection and see if the liver has been damaged.

There is no cure for neosporosis, but there are medications and physical therapy to control the symptoms. The success of the treatment depends on how soon the neosporosis is diagnosed.

Medication

The most common drug used to treat neosporosis is Clindamycin, which is usually given for four to eight weeks. Puppies with the disease may not make it through treatment once symptoms have been seen. Other drugs that have shown some promise include Ormetoprim and Sulfadimethoxine, Pyrimethamine and Sulfaquinoxaline, and Sulfadoxine and Trimethoprim. These are sulfonamides that have been successful in treating dogs with neosporosis who are not responding to Clindamycin.