Our 7 1/2 year old Siberian Husky was diagnosed with hypothyroidism after a blood work. He weighed about 92 - 94 pounds, was lethargic, thinning of hair, with dull and brittle hair. Our vet prescribed .8 mg of Tyhro-tabs, 2 times daily, so a total of 1.6 mg a day. At first he seemed more perky, with more enegry. After 10 days on the medication, he stop eating, began to drink a lot more water and didn't have as much energy. He also had diarrhea a couple times on the 2n day of not eating. We took him to the Pet Emergency, they gave him Metronidazole, 500 mg, 2x daily. Took our dog to our vet 2 days after the Pet ER, our dogs temperature was 104.5, still some diarrhea and vomited once. Vet prescribed Amoxicillin, 3x daily, and indicated to continue with the Metronidazole, and cut the Thyro-tabs to .4mg every 12 hours, even though she thought it wasn't the Thyro-tabs causing our dog to not eat, drinking a lot, high temp, diarrhea, and vomiting once. Went back to the vet the next day and the et did X-rays, more blood work and a urine test, at this visit his temp was 105.4. They also gave him fluids under his skin on his back to rehydrate and cool him down. We have not be able to get our dog to take the medicine regularly, and more often not. Even the vet couldn't get his meds in him while they had him for 1/2 a day for the X-rays and blood work. Our dog hasn't eaten a meal for 7 days. Only little bits of turkey lunch meat to try to get him to take his pills. But he has stop even taking the pills with the turkey (which he usually loves the turkey, but hardly ever gets since we try to keep him on his regular dog food. But at this point w were willing to let him eat just about anything if it would help him take his pills and the vet said to give the pills with food he loves to eat. We've even tried a pill dispenser (popper), but that didn't work. Since he was drinking so much water, we even tried beef broth to try and get some liguids with a little nutrients in him, but he smelled but would driink any of it. I asked our vet if the .8 mg 2x daily was too high of a dose and could our dog be having an adverse reaction and/or now have Thyrotoxicosis, but the vet indicate no, she didn't believe so, that the high fever is not an adverse side effect of the Thyro-tabs. From the X-rays the vet said the stomach was very enlarged and so were the intestines and they believe it is gastrointestinal cancer, and that was also probably contributing to the low thyroid issue. The vet said to stop the Thyro-tabs and focus on the Metronidazole, she added Cesernia (spelling - for nausea for 4 days) and Mitrazine (appetite stimulant for 7 days), and 1/2 imodium AD (for 3 days) to see if we can get his intestines not so inflamed so our dog may be willing to eat. But almost no luck in getting the pills into him. The vet also said with treatment for the cancer, it would only give our dog about 2 - 6 months more time, but he would have to take some more pills to stay comfortable and hopefully so he'll eat. If it was the Thyro-tabs that caused the initial problems, how long after being off of the Thyro-tabs would you think it would take for our dog to start eating again? The vet has recommended that it would be best for our dog to be put to sleep, as he can't be comfortable since he won't eat and/or take the pills. We have a vet coming to our home tomorrow to put him to sleep. It is breaking our hearts, we love him so much, he's part of the family, but don't want him to suffer. He is such a sweet dog and so loving, we feel we have to do whats best for him. But I feel so unsure, it just seems such a coincidence that only after 10 days of being on the Thyro-tabs that this all started. But 3 vets within the same practice have indicated they don't think it is the Thyro-tabs and/or the dosage amount. Don't know what else do to four our dog, put he can't go on this way without eating, he looks so sad when he looks at you now, like he's saying please help me. He hasn't been taking the Thyro-tabs for a few days and we had reduced it to .4 mg for a few days before that. I keep hoping each morning that we see improvement in him, but it seems to being getting worse, and more weak by the day. Please respond even if it doesn't help us, in case others have this same experience they may know how and who to reach out to get better way to get it fixed.