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What are Advantix Allergies?

Advantix is a brand-name flea and tick medication produced by Bayer. K9 Advantix and K9 Advantix II are some of the products you can buy over-the-counter and use as a topical flea treatment for your dog. Advantix kills fleas within 12 hours and prevents re-infestation for a month. It also repels all kinds of ticks, including those that cause Lyme disease, Rocky Mountain spotted fever, and Ehrlichiosis. Dogs treated with Advantix will be less likely to be bitten by mosquitoes or flies.

Most veterinarians consider Advantix safe for dogs, but it is a strong medication that should be used with caution. The main active ingredients are imidacloprid and permethrin, both of which can be toxic in high doses. Imidacloprid is an insecticide that belongs to a group of chemicals called neonicotinoids (they mimic the action of nicotine in the tobacco plant). Neonicotinoids act on the central nervous system to kill insects. They are less toxic to mammals, but studies on rats have found that high doses of imidacloprid can cause thyroid problems. Permethrin is another insecticide that acts as a neurotoxin. It is very toxic to cats and fish, but less so to other mammals. Advantix packages carry a warning to keep cats away from a treated dog for 24 hours. It’s also a good idea discourage your dog from swimming in streams and ponds immediately after treatment since Advantix could contaminate the water.

Side effects are typically mild when Advantix is used as directed, however, the packaging directions and warnings should be followed exactly. The medication is harmful to the eyes and mouth, and dogs should not be allowed to ingest it. Some dogs can also have an allergic reaction to Advantix. This usually manifests as skin irritation developing into a red, burn-like mark at the application site. Dogs with Advantix allergies may also have behavioral changes, like increased excitability, panting, and circling. Vomiting, diarrhea, and lethargy are associated with a severe response that should be treated immediately.

Advantix is an over-the-counter medication that treats fleas, ticks, and other pests. Many owners use this medication on their dog without a problem, but allergic reaction is possible in sensitive individuals. Redness and irritation at the application site is the most common response, but behavioral changes and other more serious symptoms are possible.

Advantix Allergies Average Cost

From 336 quotes ranging from $200 - $500

Average Cost

$300

Symptoms of Advantix Allergies in Dogs

Look for these signs after applying Advantix to your dog.

  • Skin irritation
  • Red patches resembling a burn
  • Scratching
  • Signs of pain or discomfort
  • Behavioral changes
  • Vomiting
  • Diarrhea
  • Lethargy

Types

Bayer has developed two types of Advantix.

  • K9 Advantix – the original product kills adult fleas and ticks, but not eggs, pupae and larvae.
  • K9 Advantix II – contains Insect Growth Regulator (IGR) so that it can kill fleas and ticks in all stages of the life cycle. This product is now more popular and more available than the original version.
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Causes of Advantix Allergies in Dogs

It’s not known what causes any individual to be allergic to a specific medication. Look for symptoms of Advantix allergies in the following situations.

  • After treating your dog with Advantix for the first time
  • Your dog comes in contact with another dog that has just been treated
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Diagnosis of Advantix Allergies in Dogs

Advantix allergies are typically diagnosed because owners notice unusual symptoms after they have treated their dog with Advantix. If your dog has signs of skin irritation or redness after application you should call the veterinarian for advice. If symptoms are severe the veterinarian may recommend an office visit so the dog can be examined and other potential causes can be ruled out. Gastrointestinal upset and lethargy are signs of a more serious reaction, so this should be treated as an emergency. Advantix packaging includes an emergency telephone number. Call this number for advice if you don’t have access to a veterinarian or if your dog has a very unusual response.

Some dogs could also experience a reaction after exposure to another dog that has just been treated. Advantix is one factor you should consider if your dog exhibits symptoms after interacting with other dogs. It’s recommended to treat your dog with Advantix at night, directly before crating, so the medication will remain confined to a small area. However, owners that don’t take these precautions could unwittingly expose your dog.

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Treatment of Advantix Allergies in Dogs

If you notice symptoms of an allergic reaction, stop applying the medication and wash your dog with Dawn or another detergent-based soap. Remove as much medication as possible, but avoid scrubbing too hard over the application site or other areas of irritation.

Symptoms will generally clear up in a day or two without further treatment. However, severe skin lesions could need topical ointment and antibiotics so they heal without becoming infected. If your dog is scratching at the application site, it’s a good idea to get treatment to avoid a chronic problem. The veterinarian may also prescribe Benadryl to calm the immune system and reduce histamine production. This can also alleviate behavioral changes if this seems to be a problem. Don’t give your dog Benadryl intended for humans without first discussing an appropriate dosage with a veterinarian. 

Pain medication may be prescribed for dogs that seem to be extremely uncomfortable. Other treatment will focus on the symptoms as needed. Severely ill dogs that are vomiting and lethargic may need fluids and electrolytes to avoid dehydration and support the metabolism. If the veterinarian is unsure how to treat your dog, call the Bayer emergency number where experts will be most familiar with unusual reactions to Advantix.

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Recovery of Advantix Allergies in Dogs

Most dogs with mild allergic reactions will recover without a problem. It’s a good idea to get treatment however, since this will make your dog more comfortable and treatment will avoid complications with infection. If your dog has a bad experience with Advantix, try another flea and tick medication, such as Frontline, or Advantage. Allergic reactions are possible with any of these medications, but individual sensitivity may make you dog more susceptible to the chemicals in Advantix than those in other brands.

Not every dog should be given Advantix, so it’s important to read the packaging carefully. Puppies and dogs under 4 pounds are considered too small for Advantix treatment. It should also not be given to weak, aged, pregnant, or nursing animals without the advice of veterinarian. As with any new medication, watch your dog closely after the first application, and be prepared to treat any negative responses immediately.

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Advantix Allergies Average Cost

From 336 quotes ranging from $200 - $500

Average Cost

$300

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Advantix Allergies Questions and Advice from Veterinary Professionals

Need pet health advice? Ask a vet

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Ask a Vet

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dog-breed-icon

Boxer

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Four Years

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Unknown severity

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0 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Unknown severity

Has Symptoms

Diarrhea, Pure Liquid

Used Advantix II on Monday after his bath. Diarrhea started within a couple hours. Today is Thursday. No food yesterday. Daycare will feed him chicken and rice today. Bathe with Dawn. And give him protection. Anything else we should do for him?

Sept. 10, 2020

Owner

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Jessica N. DVM

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0 Recommendations

Hello- Thank you for your question. If he is still eating, drinking, and active and there is no vomiting you can continue to feed the chicken and rice for a couple of days to see if the diarrhea resolves on its own. If it is getting worse, he stops eating, starts vomiting, or becomes lethargic then it would be time to schedule an appointment with your Veterinarian. I hope he feels better soon.

Sept. 10, 2020

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Lucky

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cockapoo

dog-age-icon

9 Years

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Moderate severity

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2 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Moderate severity

Has Symptoms

Diarrhea

diarrhea day after applying Advantix 2. The symptoms are worse during the night and early morning. During the day Lucky seems ok but then starts again at night. It has been 3 days already.

Sept. 3, 2018

Lucky's Owner

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LUCKY

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CROSS TERRIER JACK RUSSELL

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15 Years

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Fair severity

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0 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Fair severity

Has Symptoms

Overdose

Hi i treated my dog with the original advantix on the 31st july now 18 days later i found a flea and she has been scratching all night i applied another one today the 18.08.2018 SHE SEEMS TO HAVE STOPPED SCRATCHING BUT NOW AFTER LOOKING ONLINE I SEE IT'S DANGEROUS TO APPLY THIS CLOSE TOGETHER NOW IM WORRIED SICK I HAVE HARMED HER PLEASE CAN YOU HELP ME THANK YOU

Aug. 18, 2018

LUCKY's Owner

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Dr. Michele K. DVM

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1611 Recommendations

That dosage of Advantix, if it was appropriate for Lucky's weight, should not cause any toxicities for her, as the safety margin for that medication is quite wide for dogs. You should apply the next dose in 4 weeks.

Aug. 18, 2018

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Hershey

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Golden Retriever

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8 Years

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Serious severity

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1 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Serious severity

Has Symptoms

Scratching
Bumps
Goo In Eyes
Skin Hot To The Touch

I have a Golden Retriever and I have been using advantix on him for the last few years. Every year he breaks out in rashes from head to toe. At first I thought it was from the grass because he rows in it. But now I am thinking it is the Advantix since he didn't break out until after I applied the Advantix in July. How long will the reaction last if it is from the Advantix?

July 30, 2018

Hershey's Owner

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recommendation-ribbon

3320 Recommendations

Advantix (imidacloprid/permethrin) is indicated for use every two to four weeks, so Hershey should be receiving this year round and if the Advantix was the problem we would see the symptoms year round too. There are many possible sources for allergies in dogs especially seasonal allergies from the environment. Regards Dr Callum Turner DVM www.bayerresources.com.au/resources/uploads/label/file11186.pdf

July 30, 2018

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Elizabeth

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Poodle x Shih-Tzu

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2 Years

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Mild severity

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0 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Mild severity

Has Symptoms

Redness
Itching

About a day after application she has been trying to scratch at the spot, its also gotten red on the spot of application. No other symptoms besides that. Its been 2 days since application. Shes still scratching once in a while, so I figured maybe giving her a bath would help? What should I do?

March 22, 2018

Elizabeth's Owner


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Dr. Michele K. DVM

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1611 Recommendations

Thank you for your email. Without seeing Elizabeth's skin, I"m not sure if a bath will be enough to stop the irritation, but if she seems to be reacting to the Advantix, it would be a good idea to try and wash the medication off of her skin. If her skin continues to react, she may need to see your veterinarian. They can also help you with options for flea control.

March 22, 2018

I bathed her, and when looking more closely at the irritation, it looked more like she had just been scratching at it too much. After her bath she hasn't tried to scratch again. Thank you for the response

March 22, 2018

Elizabeth's Owner

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lexi

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Maltipoo

dog-age-icon

8 Years

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Serious severity

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0 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Serious severity

Has Symptoms

Itching And Red Spot

I used the correct dosage of Advantix. My dog started itching and biting at herself the next day. She has red spots on her lower abdomen. Took her to the vet and she is on steriods to bring down the inflammation. Hoping it works.

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Luke

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Boxer

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4 Years

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Moderate severity

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0 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Moderate severity

Has Symptoms

Head Tremors
Body Shaking Like Cold

I have been using K9 advantix 2 on my boxer since about 1.5-2years old. A few months ago Luke was weak and didn't want to walk. I almost had to carry him in from a potty break. I was very worried. I noticed his head would bob around and he looked to be shaking. I thought maybe he ate something or maybe a tick bit him, but he had his flea & tick in as well as a lyme shot. I looked for anything abnormal or if he hurt a leg or something. After calling our vet I kept a close eye in him all weekend. Still to this day have no idea what caused it. Then it hit me that it could had been a reaction to the Advantix 2. I haven't put it on him since tbat incident and haven't had any tremor or shaking issues. Could I be right about this? Has anyone else had an issue like this? It stinks because the stuff actually works and we are in an area where something is definitely needed to fight off the ticks & fleas.

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Winston

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Dachshund mix

dog-age-icon

1 Year

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Moderate severity

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0 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Moderate severity

Has Symptoms

Itching
Panting
Restlessness

I gave Advantix II to my 1 year old 26 lb. Dachshund mix. What a mistake. He (Winston) is suffering with extreme itching and scratching at areas all over the body. The application site shows swelling and slight discharge. After a visit to the vet, he is on Tameril-P for a week. He has been bathed with Dawn detergent, but is still suffering between doses. All we can do now is to wait until it's out of his bloodstream. I have thrown away all the Advantix I have and will never risk that on any of my other dogs.

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Spot

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Rat Terrier

dog-age-icon

14 Years

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Critical severity

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0 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Critical severity

Has Symptoms

Shaking
Weakness
Vision Loss
Confusion

I gave my 15 lb Rat Terrier Advantix II on Friday (correct dosage). By Saturday morning he was shaking, falling over, and confused. It seems like his eye sight is worse too. I washed him in Dawn detergent to get it off Saturday morning. He's 14 years old, completely deaf and already has some vision loss. The vet said it should wear off in a few days. Now it's Monday. He's drinking, low appetite (but does eat some). No vomiting or diarrhea. Just very weak and seems confused. The vet also said there's not much to do but give him some Benedryl... which I did. That seems to help him sleep. What more can I do?

dog-name-icon

Theodora

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Soft Coated Wheaten Terrier

dog-age-icon

5 Years

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Serious severity

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0 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Serious severity

Has Symptoms

Restless, Twitching, Panting.

Our Soft Coated Wheaten Terrier was given one dose of Advantix this afternoon at 3pm, by 5pm she was restless and unable to settle. I called the vet who asked to see her. She said it was Advantix allergy and her symptoms should settle down. At 11pm she had become more agitated, lying down then getting up, pacing and panting. We called the out of hours vet who suggested taking Teddie for a walk, if there are more signs of twitching or seizure we will be taking her back to the vet who said they could sedate her and monitor her symptoms through the night. Our doggy bear is a very unwell girl and we are hoping she will be ok. At this time, we are not so sure.

Advantix Allergies Average Cost

From 336 quotes ranging from $200 - $500

Average Cost

$300

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