
- Lethargic
- Tachycardia - Fast heart beat
- Polyuria - Frequent urination
- Darker colored urine
- Tarry/dark stool
- Polydipsia - Increased thirst
- Pallor - Paleness seen on the gums, underside of the ears and the inner eyelids
- Jaundice (icterus) - Yellow pigmentation in the sclera (white part of the eye), along the gum line, pinnae (inner ear flap), genitals and on the abdomen
- Weakness
- Decreased ability to exercise
- Dyspnea - Shortness of breath
- Lack of appetite
- Fainting
- Nose bleeds
- Seizures
- Vomiting
- Collapse
- Primary IMHA (idiopathic) - No underlying reason for the disease (this is the most common type of IMHA; 60-75% of patients with immune-mediated hemolytic have primary IMHA)
- Secondary IMHA - Is triggered by a condition or activated by an agent
- The body’s own immune system is at fault.
- Genetic implications
- Recent vaccination
- Medications
- Tick exposure
- Zinc or copper intoxication ( ingesting pennies, batteries, zinc oxide cream)
- Cancer
- Toxins
- Stress of estrus
- Infections caused by Babesia, Ehrlichia, and Leishmania
- Complete blood count - Can determine the patient’s platelet, red and white cell count and can also help determine if there is a bacterial infection; patients with IMHA will have a low red cell count, higher white cell count, low platelets and elevated liver enzymes
- Serum chemistry test - Evaluates organ functions and the electrolyte balance
- Blood smear - Can find abnormalities in blood cells; 89% of patients with IMHA have spherocytes, which are red blood cells shaped like spheres, instead of the normal disk shape
- Reticulocyte count test - Measures how fast red blood cells are made and released from the bone marrow
- Slide agglutination test - Can help determine if the red blood cells are being affected by an immune disease
- Coombs test - Can visualize/ detect the immune system’s antibodies on the surface of red blood cells
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