Non-Regenerative Anemia in Dogs

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I have an 11 year old beagle named Cookie who just got diagnosed with nonregenerative anemia. We left her with a dog sitter for a week and when we came back she almost passed out when she saw us. It was like she lost control of her body, she fell over and couldn't get back up for a few minutes. She has Addison's disease so we assumed that the stress of not seeing us for a week made her pass out, but then it happened a few more times and we took her to the vet. They also said her bone marrow is decreasing. Looking back now, I think the problems started before we even left. Her breathing was a lot heavier than normal for at least a few months before. They told us that if her PCV gets lower (it's at 17 now) we'll have to do a blood transfusion. We're a little unsure about how to handle everything. Of course they told us that one transfusion might not be enough, but just one is expensive and we've already spent a lot getting to this point. I don't know how far we can keep going. Sometimes she doesn't have an appetite but if we bring out her favorite foods she's always down. And usually she'll eat at some of the day, so she isn't going long times without food. Are transfusions really the only option? What is the process afterwards, how is the transfusion going to help? Is this inevitably going to keep happening?

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I took my dog to ER because I found a bruise on his leg and his abdomen incision scar was getting darker(he had recently been treated for severe sepsis and discharged from hospital 12 days prior, with anemia tested and resolving 9 days prior). He had completed his antibiotics 4 days prior. They found he did not have platelets and a low red blood cell count. He was admitted and administered steroids to prevent immune system from attacking red blood cells/platelets and required blood transfusions daily. Five days later they performed the Recticulocyte test, and results given the next day said he had nonregenerative anemia. Would you have tested his blood for infection/sepsis upon arrival or at some time to determine if that could be reason why he wasn't creating platelets given his history (or even not given his history but in general)? If sepsis was found, what would be the treatment, likelihood of survival?

Thank you. Leo died the day of the results. They found fluid in his abdomen that they said was septic. His abdomen had started looking swollen days before but was thought due to enlarged liver. It seems the antibiotics had kept infection at bay, and they think must not have completely gone in the first place. I guess I am just trying to understand it all. Since he was improving but all of a sudden had the bruises appear and a drastic decline. Is there any way keeping him on antibiotics longer could've rid him of sepsis? Maybe we should've had his anemia, etc tested again after the antibiotics? And if it had worsened could re-upping on antibiotics been an option to eliminate the infection? Hoping this post can help others in the future. Just want to add, when you're worried about your pet but your regular vet assures you all is good, follow your intuition and go straight to emergency or another vet for 2nd opinion immediately. Leo could be alive if I had. And get pet health/accident insurance-so you won't have to worry about emergency costs and expensive treatment.

Has Symptoms

I have an 11 year old Lab Mix. I took her to my vet because she was lethargic, having trouble going down our porch steps and defecating sometimes without warning that she had to go out. The vet did an ultrasound because she felt a mass in her stomach and remarked that something was wrong with her eyes. The mass turned out to be her spleen which is incredibly enlarged. Her blood tests came back as non-regenerative anemic with her monocytes showing as just over the normal range. They did an x-ray of her chest and abdomen with which came back as unremarkable. She was also having trouble seeing. By the time we got home, she was almost completely blind. They sent her home with Doxycycline, Gabapentin, Dermamaxx and Pepcid to see if anything improved. She seems to feel better, but cannot see a thing. She does not indicate that she needs to go out to go to the bathroom, and I can see that her eyes look like they are bulging and the iris is a little red. The vet seems baffled as to what's causing all of the problems and referred us to an ophthalmologist to see if they can determine anything further. What is your opinion for the cause(s) and treatment?

Has Symptoms

My dog has a form of non-regenerative anemia, and my vet believes it is due to the bone marrow not producing red blood cells. He's had 2 transfusions in the last 2 weeks, and those coupled with medicine and diagnostic costs have left me very near the top of what I can afford. If I am unable to do another transfusion if/when he needs it in the next couple weeks, what am I looking at in terms of options? If his PCV were to drop below 10, what are the repercussions (lowest it has been is 12)? Basically, if he doesn't get a transfusion what complications would arise, and what would he die from at that point? I don't want him to suffer, and would likely put him down if it gets that bad. I just haven't been able to find an article that cuts straight to the point of what the cause of death would be if anemia were to go untreated. He's an extremely calm and complacent dog, and it is hard to tell if he's experiencing discomfort or pain because he's so extremely chill and unreactive when he's perfectly healthy.

Has Symptoms

My dog was fine one day and the next he wasn't. Listless, weak, pale membranes. dark urine. He appeared to go downhill quickly. Took him to the vet, Hct, Hgb, and RBC low and within two days even lower. He could barely walk. Admitted to hosp. Transfused and became even worse. Had a bone marrow biopsy, didn't appear as abnormal as I expected but def. non-regenerative anemia, actually PRCA, no other cells affected. He was too weak and his body never had a chance to respond to steroid therapy. I lost him. I will never get over this loss and I seek answers everyday regarding my "shusky" How common ins this and why. Can the multi-valent vaccines cause the condition? How come some dogs survive. Why did my pup go downhill so quickly? Does it sound like an IM anemia. I'm always looking for news and new treatments for this dreaded condition. Thank you.