Exocrine Pancreatic Insufficiency Average Cost

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What is Exocrine Pancreatic Insufficiency?

The pancreas is a complicated organ responsible for producing a variety of substances important for breaking down food and aiding in digestion, which allows your cat to properly absorb nutrients. In cats suffering from exocrine pancreatic insufficiency, the pancreas fails to produce sufficient amounts of digestive enzymes. This starts off a chain reaction of poor nutrient absorption and poor digestion of food that can have a significant impact on the health of your cat if left untreated for a long period of time.

Symptoms of Exocrine Pancreatic Insufficiency in Cats

Exocrine pancreatic insufficiency is a difficult condition to diagnose given the individual symptoms can often mimic other conditions. The differentiating characteristic is a chronic presence of one or more of the following symptoms:

  • Weight loss despite adequate appetite
  • Chronic diarrhea
  • Poor coat condition
  • Increased appetite
  • General lethargy
  • Vomiting

Causes of Exocrine Pancreatic Insufficiency in Cats

Exocrine Pancreatic Insufficiency occurs when the pancreas produces insufficient quantities of digestive enzymes. These enzymes are secreted into the digestive system of your cat, allowing for food to be broken down into micronutrients, which provide important support for your cat’s daily functions. Some of the most common causes of exocrine pancreatic insufficiency include:

  • Chronic inflammation of the pancreas
  • Parasitic infections
  • Cancer
  • Diabetes
  • Damage caused by chronic pancreatitis

Diagnosis of Exocrine Pancreatic Insufficiency in Cats

Diagnosis of exocrine pancreatic insufficiency in your cat will begin with a thorough physical exam by your veterinarian. Given the way the symptoms have commonalities with other diseases, your veterinarian will perform a differential diagnosis. A differential diagnosis is a type of procedure in which a veterinarian rules out conditions with similar symptoms, rather than using symptoms to identify one particular condition. It will be important to provide your vet with a complete list of symptoms as well as their approximate date of onset and whether they have remained stable or have changed over time.

During the exam, your veterinarian will perform a full blood panel, a urinalysis, and a test for parasites. Drawing blood for the tests requires a simple needle stick and is quick and relatively painless. In order to test for parasites, your vet may need to collect a stool sample.

Your veterinarian will also order a blood panel that looks at digestive function and the pancreas, called a GI panel. This is a series of four analyses, one of which measures trypsin-like immunoreactivity. This is the definitive test for diagnosing Exocrine Pancreatic Insufficiency in cats. The test will also measure levels of vitamin B12. Most cats suffering from exocrine pancreatic insufficiency are also deficient in this vitamin.

Finally, if your cat is found to be suffering from exocrine pancreatic insufficiency, your veterinarian may also want to run additional tests to confirm whether your cat has diabetes. Diabetes causes damage to the pancreas over time and exocrine pancreatic insufficiency can often be a side effect. 

Treatment of Exocrine Pancreatic Insufficiency in Cats

Once the pancreas has sustained damage, it does not typically recover full function. Treatment of Exocrine Pancreatic Insufficiency in your cat will usually involve lifelong supplementation with digestive enzymes to allow the cat to appropriate process food and nutrients. Digestive enzymes typically come in powdered form and some cats may be unwilling to eat the supplement. Owners should work with their vets to identify appropriate soft foods to mix with the enzymes. Alternatively, eating raw pancreas has been shown to increase pancreatic enzyme levels. This may be used in cats with extreme aversions to supplemented enzymes.

Cats with exocrine pancreatic insufficiency will also need to be supplemented with vitamin B12 since they are unable to absorb appropriate amounts of this important vitamin from their food. Vitamin B12 can be administered on a routine basis with shots given beneath the skin.

Recovery of Exocrine Pancreatic Insufficiency in Cats

While exocrine pancreatic insufficiency can be managed over the life of your cat, there is generally no known cure for the condition. Supplementation with appropriate levels of enzymes will help your cat with absorbing food, but will not completely manage the condition. Your cat’s diet will most likely need permanent modification. It will be particularly important to reduce fat intake, since fat is typically highly dependent on pancreatic enzymes for appropriate absorption.

Long-term, cats who suffer from exocrine pancreatic insufficiency suffer no loss of lifespan or quality of life as a result of their condition. Your cat will need to maintain a regular veterinarian visit schedule in order to monitor blood levels and to ensure your cat is gaining weight and getting appropriate nutrition. 

Exocrine Pancreatic Insufficiency Questions and Advice from Veterinary Professionals

13 Years
Mild condition
0 found helpful
Mild condition

Has Symptoms

Weight Loss vomiting, constipation
Weight Loss

Medication Used


I have a 13 year old male cat who has been having constipation/diarrhea problems for a while now (off and on 6-8 months) and he has also lost weight in this time. In January 2017 he weighed 13 lbs and now is down to 10 lbs. He's had multiple blood panels run, 2 ultrasounds (one in July 2017 and another in September 2017) as well as multiple X-rays. Both vet's say that his blood panels look great and nothing of concern shows up on any of his tests. He was put in a weight management food (Hill's prescription W/d feline) so I'm not sure if that accounts for his weight loss? But I would think it since he was starting to lose weight before he got put on that in July. They put him on that because they said it wasn't diarrhea problems, he actually has well formed poop but was having trouble passing it so he was put in this food and it seemed to help solve the problem. He started pooping more normal stool but he's still losing weight. He acts normal. Eats like normal. I just know this weight loss can't be normal and want to get to the bottom of it before he continues to drop more weight. Any thoughts? I don't know how to look for cancers other than what has been done which showed nothing so I'm at a loss. Would an exocrine pancreatic insufficiency show up in a blood test?

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
2746 Recommendations
Normally in cases of exocrine pancreatic insufficiency the regular blood tests come back normal, however in some cases some liver enzymes may be elevated but we cannot rely on this alone; this is really one of those conditions which we have a specific test to diagnose the condition and we have to be actively testing for it. Also, animals affected by exocrine pancreatic insufficiency will have voluminous diarrhoea; if there is extreme weight loss and Sobe’s body condition score is suffering you should return to your Veterinarian. Regards Dr Callum Turner DVM

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5 Months
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Oily coat

Hello! We believe our kitten has this insufficiency. Rather than pay the $300+ to do the test, is it safe enough to try this enzyme supplement powder for a bit to see if it solves her symptoms?

Dr. Michele King, DVM
Dr. Michele King, DVM
1255 Recommendations
Thank you for your email. EPI is quite uncommon in cats, and very uncommon in kittens. Parasites are much more common in kittens, as is food intolerance. It would be best to have Milie seen by a veterinarian, and examined. They can check a fecal sample, and direct you to the best treatment for her. Supplementing with pancreatic ezymes will do nothing to help her if she doesn't have EPI.

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7 Years
Moderate condition
0 found helpful
Moderate condition

My cat Turbo was diagnosed with EPI about a year and a half ago. My vet prescribed Pancreved powder with food and B12 injections once a week for 6 weeks, then once a month thereafter. He responded well to this treatment and gained some weight back. Recently, I noticed he looks a little skinny and also lethargic. His coat doesn't seem as silky and shiny as it was months ago. Several months ago I also changed from mixing Pancreved powder with his food to giving him the Pancreved pills right before feeding because he started refusing to eat the powder-mix. He takes the pills without fail everyday, but I'm wondering if it just might not be as effective as the powder? Should I restart the powder regimen instead? Also, should Turbo be given B12 injections regularly? What kind of diet would be beneficial for Turbo and how can I get him back to his normal, playful self?

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
2746 Recommendations
Firstly I would try to give the pills fifteen to thirty minutes before food to see if that makes any difference, feeding half an ounce (15g) of raw pancreas can be tried too; the B12 injections should only be given if they are deemed necessary by your Veterinarian. As for diet, Turbo should already be on a fat restricted diet which shouldn’t be changed. Regards Dr Callum Turner DVM www.msdvetmanual.com/digestive-system/the-exocrine-pancreas/exocrine-pancreatic-insufficiency-in-small-animals

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Brandon, Robert
18 Months
Fair condition
0 found helpful
Fair condition

What is the best treatment for felines with exocrine pancreatic insufficiency. I have two cats that were diagnosed in January and I am still battling with runny stools. Little is known in South Africa about this condition in cats so treatment seems to be a trial and error kind of thing. They currently on exocrine pancreatic insufficiency supplements which they get in soft food before getting their pellets which are iams rich in chicken pellets, I've tried mixing their supplements with their pellets they don't eat it. Thank your the symptoms that are present are loss of weight even though the cat is eating an enormous amount, runny stools and a very dull coat, also lack of enthusiasm in anything. After the treatment they are up and running around gaining some weight but still battling with a runny stool.

Dr. Michele King, DVM
Dr. Michele King, DVM
1255 Recommendations
Thank you for your email. The dose of pancreatic enzyme supplementation can vary depending on the animal, and they may need more supplementation. It seems they are headed in a positive direction, and it would be a good idea to give your veterinarian a call, describe what is happening with them, and see where they are as far as dosages for the enzymes. I hope that they continue to do well.

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