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What is Revolution Allergy?

Revolution (also called selamectin) is a topical medication that is used for flea and heartworm prevention. While the product has been tested and is safe, some cats may experience a reaction to it where their immune system will overreact to an element of the medication, leading to allergy symptoms. While symptoms in cases of a reaction are usually mild, it is important to seek medical attention should you notice a reaction after administering the medication in order to ensure the best outcome for your cat.

When a cat is experiencing an allergy to Revolution, it is the result of their immune system overreacting to an element of the medication upon it having contact with their skin or being ingested.

Symptoms of Revolution Allergy in Cats

Symptoms of an allergy to Revolution are similar to those of other allergies. These include:

  • Watery eyes
  • Runny nose
  • Inflammation in their skin
  • Scratching, biting and/or licking his skin
  • Hair loss
  • Skin rashes
  • Hives
  • Respiratory issues
  • Lethargy

Types 

Medications to prevent fleas and heartworms in your cat are typically available in topical and ingestible forms. The topical medications will be applied to the back of your cat’s neck on his skin. Should your cat experience an allergy, it can present itself right away or within a few hours or days. The topical form of the medication will be administered to your cat once a month to prevent flea and heartworm infestation. Other products that protect your cat against fleas and heartworms include:

  • Advantage multi
  • Advantage/Advantage II
  • Frontline Plus
  • Comfortis

Causes of Revolution Allergy in Cats

The active drug in Revolution is selamectin. Revolution has been tested in studies using ten times the recommended amount without negative reactions occurring, however, an allergy or negative reaction, while rare, is possible. An allergy to Revolution occurs when the mast cells of your cat’s immune system mount an aggressive response to one of the components of the medication. The mast cells release a histamine which will lead to inflammation in the tissues it comes in contact with as they attempt to fight what they see as an intruder. The histamine that is released leads to the allergy symptoms your cat experiences.

Diagnosis of Revolution Allergy in Cats

Should you notice concerning symptoms in your cat after applying Revolution, you will want to take him to your veterinarian. After conducting a full physical examination, your veterinarian will ask you for information in regards to the symptoms you have noticed, when you first saw them and any changes you have observed. The skin symptoms your cat is experiencing will lead to your veterinarian taking a sample of his skin cells through skin scraping so that he can view them under a microscope to see if there are any parasites, yeast or bacteria present. Once those are ruled out, your veterinarian will consider possible causes of your cat’s symptoms.

A complete blood count and chemistry panel may be taken; should the specific white blood cell level be high it will point to an allergy being present in your cat. The results of the blood work will help eliminate other causes of the symptoms your cat is experiencing. Should your cat be experiencing respiratory problems, a radiograph may be taken so that your veterinarian can view his lungs and rule out illnesses like pneumonia or bronchitis.

Your veterinarian will likely ask you for information about the diet of your cat as well as any supplements and medications that he takes. Be sure to mention when you administered Revolution to your cat as this may help your veterinarian pinpoint the cause of his symptoms.

Treatment of Revolution Allergy in Cats

Your cat’s treatment will depend on the symptoms he is experiencing. Should your cat be experiencing breathing difficulties, these will be addressed immediately with oxygen therapy as appropriate. An antihistamine will likely be administered to decrease the inflammation your cat is experiencing. Unfortunately, antihistamines are not effective in all cats, so this may or may not impact your cat’s condition. The antihistamine may help with any respiratory system swelling as well as skin inflammation. Should your cat be experiencing skin symptoms, shampoos and topical ointments containing hydrocortisone may be recommended to give him immediate, though short term, relief. 

Corticosteroids (either injected or administered orally) are often very helpful though they have serious side effects when used over a long period of time. Should your veterinarian recommend corticosteroids, he will usually plan to monitor your cat’s blood chemistry levels to catch any potential issues as a result of the medication. If your cat develops a secondary bacterial infection due to their excessive licking and scratching, an antibiotic will be prescribed.

Recovery of Revolution Allergy in Cats

You will want to work closely with your veterinarian to ensure the best outcome for your cat. Should your cat react to Revolution, you will want to avoid giving it to him in the future. Fortunately, there are other options for flea and heartworm prevention for your cat and you can choose one of those for his protection. Your veterinarian may recommend follow-up appointments so that he can see how your cat is doing and make any necessary changes to his treatment.

Revolution Allergy Questions and Advice from Veterinary Professionals

Echo & Clutch
short hair
4 Years
Fair condition
2 found helpful
Fair condition

Has Symptoms

Fever
Lethargy
lack of appetite

Not entirely sure if it’s a reaction or not. But 2 days ago I gave my cats Revolution. They’re super lathargic; one cat sleeping near the window & the other next to me on the bed with no evidence of moving until I come home from work and pull the covers off of them. One cat (who likes to sleep in the bed) seems a bit warmer than usual, but other than the lethargic attitude and warmth they seem fine. It’s just like they have no motivation which is a little odd (not even to eat or drink or use the litter box unless I make them get up & even them they just lay in front of their bowls and sleep). Should i schedule a vet visit or see if this passes?

My god!! What do we do if cat is experiencing these symptoms!!! I’m terribly worried. Shall I go to ER ?

I used Revolution on my cat for years, but switched to the Revolution Plus. Put it on Monday morning, she was lethargic by evening. I took her to the vet that night, she had bloodwork & an X-ray which showed nothing wrong. They said she had a fever, treated that and let me take her home last night. She was still lethargic, so I took her back this morning. She went into cardiac arrest and died. I AM SO ANGRY! I don't think they believed me when I said it had to be the medicine, so they didn't do anything to try to treat it as an allergy. I feel like I failed my best friend!

My cat had an extremely bad reaction to Revolution. Within 2 says of administration she became lethargic, stopped eating or drinking, felt hot, dropped weight, and remained that way for over a week. Vet said to just keep a good eye on her. My sweet baby never fully recovered and died about 2 weeks after applying. I NEVER would’ve used Revolution on her if I’d ever heard anything about some cats having a bad reaction to it. It seems highly irresponsible to continue to manufacture, sell, and prescribe this product knowing it’s potentially fatal. I’m so angry I’m beside myself.

My cat is having the exact same issues. Burning up, lethargic and loss of appetite. How are your cats now?

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Omey
Shorthair
4 Months
Serious condition
-1 found helpful
Serious condition

Has Symptoms

lethargy, loss of appetite
Lethargy

I'm not sure whether it is the adverse effect from revolution but my kitten which is about 3 and a half months when he was administered, started to show simptoms like loss of appetite and extreme lethargic until now, almost 2 weeks later.

I've brought the kitten to the same vet to check if he was sick but the vet said physical examinations showed he's ok. The kitten has lost 200gram in 2 weeks time (from 1.7kg to 1.5kg). The vet just prescribed a supplement to increase appetite and asked me to bring back the kitten in 2 weeks time for follow up. But,i am really worried as i see the condition is not improving at all today.

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Beam
domestic short hair
9 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

smacking lips
Smacking lips, Hiding, Vomit
Smacking lips, Hiding

My cat took her first Revolution dose yesterday, today she's been smacking her lips and sticking her tongue out a lot, like she's got something in her throat, vomited and has been hiding away from me :(. I feel like this drug is too strong, should be halved, and/or spread about bi-monthly. This way if a cat has a severe reaction to just the half, it is less life-threatening or hard on the kitty and an alternate solution can be found.

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Simon
Siberian
2 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Sneezing

I have noticed recently a pattern every month that when I put Revolution on the back of my cat Simons neck he starts to sneeze for extended periods of time with in a few hours. His eyes run, and he grooms his face constantly. unfortunately We didn’t put it together till this last treatment. I just thought he had allergies that came and went. He already loves water and drinks a lot. Would an antihistamine help?

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Murphy
Persian
2 Years
Critical condition
1 found helpful
Critical condition

2 year old doll face Persian. Nutered. 10lbs. Vet weighed him and sold us revolution. Very soon after he hid in the closet. I gave him food,water and clean litter box. He curled up in the corner of the litter box. He was out of it. No recognition of us, food or water. 2am I checked him. He had passed out face down in the litter box. I picked him up, cleaned his face and cuddled him. After 12 hours he slowly started to return to normal. Second cat Siamese, same age and weight to trouble at all.

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Athen
Tuxedo
7 Years
Moderate condition
1 found helpful
Moderate condition

Has Symptoms

Hair Loss

I’ve used revolution on my cat for years with no issue. This time however he started pulling and scratching hair out at the application site. He was taken to the vet before getting our new round of revolution and other than being treated for worms was in good health. The vet does not believe that it is a cross reaction.

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George
Cat
9 Months
Serious condition
1 found helpful
Serious condition

Has Symptoms

Extremely Lethargic
Loss of Appetite

Medication Used

Revolution

Ever since I applied the revolution my cat has been very lethargic. I didn't realize it at first just noticed he hadn't been around it seemed as though he had lost weight he is so lethargic we have to carry him to his food and water, he drinks a few sips, takes a few bites and then he wont move so we have to carry him to his food and water and carry him to his potty Box he is using the potty when we bring him to it. I've also been feeding him some cat formula through a syringe to make sure hes getting enough liquid and nutrients. I'm very worried is this a normal reaction in some cats?

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Betty boop
Bomb
11 Days
Mild condition
0 found helpful
Mild condition

Has Symptoms

Licking at Genitals

So I gave my cat half a dose that's was required I was scared she may have a bad reaction ..its now been a week I started her outside now I am seeing flea she has never had fleas so a week later I gave her the other half dose that is required for her weight I she jerked during her application so I wiped it off ware she could lick it..does anyone have an opinion on this?I'm terrified she will become sick

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Don Juan
domestic short hair
13 Years
Serious condition
2 found helpful
Serious condition

Has Symptoms

watery eyes and loss of hair

My 13 year old male cat has open soars around his upper and lower neck and top of his head. they seem to heal and than come back in the same spots. Have taken him to the vet 5 times and after many test and medication and change of diet the soars still come back. They are also itchy. could it be the revolution?

One of my four cats has had this same issue with sores on his head, around his neck and even worse on his back at the base of his tail. He has had Revolution used o him in the past with no reactions. However these last 2 times have been terrible! Vet continues to say it is a "flea" allergy but funny during the winter months when I did not use Revolution on him he had no dry skin or patchy spots with scaly skin. He bites at his skin (especially on his tummy) and then I have to treat it using Aveeno Skin Relief Bath Treatment which is a dry mixture and I mix it with a little water and make like a paste and dab it on his tummy. This helps relieve the itching, smooths the irritated skin and dries up the scaly areas. This may not be for everyone but he is not able to lick this off as if he has done when I applied a tiny amount of cortisone cream (1%) used as the vet recommended. No more Revolution for him!

My cat is doing the same thing. I didn't equate it to the Revolution until now. I've spent a considerable amount of money at the vet and she recommended the Revolution. He has open sores on the top of his head also from scratching. He is constantly licking and biting himself. I believe it might be a reaction to the Revolution.

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Mittens
Short hair dome
2 Years
Serious condition
0 found helpful
Serious condition

Has Symptoms

Drooling
Panting
Open mouth breathing
Coughing

Our cat is asthmatic. It’s taken a while to figure this out but each time I give my cat revolution she seems fine. Then a few days later she starts having severe attacks with open mouth breathing, drooling and coughing. I feel horrible about not realizing sooner that my cat must be allergic to Revolution. Is there anything that I can do to help her. My son gave her prednisalone, tributiline and my albuterol inhailer. She is breathing fine right now but I know in a few hours she will be in distress and the vet is not open.

Go to an emergency animal hospital asap!
Do not wait for the vet to open for symptoms like these.
This is almost 2weeks later. I sure hope Mittens is okay.

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Sasha
Tortoise
8 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Asthma
Asthma & Lethargy

Each time my adult cat receives a revolution treatment, her asthma and labored breathing subsides greatly.

I believe she was having allergic reactions to flea bites and was scratching patches of fur off her tail section.

How do I help her not have asthma and lethargy about at about 1 weeks before the next months dose?

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Stubby
Maine Coon
20 Months
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

scratching, sores, alopecia
scratching, sores, weight loss
scratching, sores
scratching

My year and a half old Maine coon mix, Stubby, has been biting himself and itching continually since applying Revolution. I didn't put two and two together to attribute it to the Revolution we just began giving him the first of 2019. He has lost weight and a considerable amount of fur. He has been self-mutilating and biting himself raw. The vet said he didn't have fleas or mites or worms. The skin test she did showed some kind of bacterial infection which she treated with an anti-inflammatory short and a anti-biotic. These relieved the symptoms for two to three weeks and it started over again. The vet urged me to give him another treatment of Revolution to protect him from fleas and mites. After I gave him the last dose, he began mutilating the top of his head (scratching himself raw). I used colloidal silver gel on it which healed it rapidly, but he would scratch it raw again. The last time I visited the vet, she recommended a Total Health blood draw to rule out any other possible physical problems. He came out fine on that but is still not doing well. I have just recently changed his food over to Royal Canin hydrolyzed protein dry food (he only likes dry food) because the vet suggested he might have an allergy to the protein in his diet. I now believe it is very possible this problem is entirely due to the Revolution. Prior to the first of the year, he had been getting feline Advantage treatments and was fine. I appreciate any feedback I can get. I can't afford the vet fees, and my heart is breaking for this kitty. Please help!

Get a second veterinary opinion

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Pretzel
Cat
2 Years
Critical condition
0 found helpful
Critical condition

Has Symptoms

open mouth rapid breathing
dilated pupils
decreased appetite and thirst
respiratory distress
personality changes

I gave my 2 1/2 year old cat Revolution Plus. After I first applied the topical flea medication, I noticed she had very dilated pupils and she ran around acting startled and disoriented. Within 12 hours she was in respiratory distress and I rushed her to the emergency vet hospital where she spent 6 hours getting oxygen. She was breathing very heavily, with her mouth open, panting and meowing, acting in fear. After her 6 hours getting oxygen, and also getting a diuretic because x- rays showed she could be having heart failure as well, she seemed to breathe easier and didn't need oxygen any longer. It has been a week now since that occured and she still has decreased appetite and decreased thirst but her personality is starting to come back to normal. We got a second opinion and the vet thinks she had a severe reaction to the Revolution Plus as she doesn't have any signs of respiratory or cardiac issues now. She is stopping the diuretic that the ER vet gave her and we will see if she has any long term heart effects from the severe reaction she had to the Revolution Plus.

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Buff
tabby
1 Year
Mild condition
0 found helpful
Mild condition

Has Symptoms

Bald spot

We put Revolution on our cat. Shortly after, we noticed that he has a bald spot right where we placed the medicine. We used Revolution on him throughout last year and he never got a bald spot before.

Hi, I have used revolution for the last 6 months with no adverse reaction. About two weeks after the last dose and one month after having him spayed I noticed a bald spot at the spot where I apply revolution. Two days later I noticed several bald spots on his neck under his chin, but the skin is normal and he doesn't scratch there. I took him to the vet and after he examined him he said he was healthy and it was probably an allergy to a plant or possibly one of the foods I give him. So I have started the elimination process which is difficult as he wants to go outside during the day. After reading your post I might try stopping the revolution to see if it is the culprit.

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Tigger
tabby
13 Years
Serious condition
0 found helpful
Serious condition

Has Symptoms

weak back legs, wobbly

Gave Revolution Plus to 3 cats, 2 were fine, my third has symptoms of weak back legs...it was very hot outside, so, I thought it was the heat, I closed the cat door and brought him in, but a few days later he is not better. I have an appointment for Monday, but am worried I waited too long, it did not occur to me at first it was a reaction to the Revolution until I started reading about it. WARNING LABEL ON BOX SHOULD BE MORE VISIBLE

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Lunas
American
9 Years
Serious condition
0 found helpful
Serious condition

Has Symptoms

missing fur
scratching
Bald spots
Watery eyes
Neck, throat and head affected
Lethargic

Medication Used

Prednisolone

My cat has a mild food allergy and the vet prescribed revolution plus as part of their allergy protocol even though my cat has never had fleas or ticks etc. The day after revolution plus was given, she had watery eyes that left her cheeks wet and she couldn’t stop sneezing. Things progressed to excessive scratching around her neck and throat and she ended up with a lot of missing fur, sores and patches of missing fur from the top of her head. I took her to the emergency room where she was prescribed prednisolone and antihistamine. I was told her body was inflamed from the allergic reaction. The prednisolone has helped but when she is tapered off the scratching and bald spots return. I wish I knew how long it would take for the Revolution Plus to leave her system.

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Luna
domestic short hair
3 Years
Fair condition
0 found helpful
Fair condition

Has Symptoms

Itching

Sorry if this is a duplicate, but i lost my last attempt! My indoor cats somehow got fleas . My vet recommended Revolution and i applied it yesterday. Everyone seems fine except my 3 year old cat, Luna. She is scratching excessively at the application site. I'm afraid this might be an allergic reaction as opposed to the fleas because it seems to be exactly where i applied the medication. Of course, its now Sunday and my vet is closed. I'm not sure if this warrants an emergency vet visit or if it's ok to give her Benadryl and see if that helps til i can get her to my vet tomorrow? She has no other symptoms except for the scratching. I also thought about washing the application site to see if it helps.

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Apollo
short haired
14 Weeks
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Loss of fur
Bloody
Scabbing

My 3.5 month old kitten was given Revolution and he has developed a patch missing fur. It doesn't seem to be getting better. I come home after a few hours and it's bloody and scabby. I'm just not sure if that's from the cat itself or his body reacting poorly to it.

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Colby, Apricot, Thimble
Maine Coon
4 Years
Mild condition
0 found helpful
Mild condition

Has Symptoms

Eye dilation

I’ve been giving my 3 cats Revolution monthly (actually every five weeks) for three years now. This time I noticed all 3 cats had their eyes dilated with no change when passing from light to dark areas. Does this normally happen with Revolution and I just never noticed it? Two cats are Maine Coons and one is a rescue who has traces of Persian characteristics (not the face part).

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
That is not a normal response to Revolution, but it is odd that it happened to all 3 cats. Is there a possibility that they got into something else? If the signs that you see don't resolve, it would be a good idea to have them examined by a veterinarian to make sure that they are okay.

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Melvin
dsh
7 Weeks
Moderate condition
3 found helpful
Moderate condition

Has Symptoms

Diarrhea

7 week old kitten given application of revolution by vet to treat fleas and worms-had diarrhea start 2 days after that! Is that normal? He is eating fine and drinking fine.. but the diarrhea is so bad he shakes from the pain when he goes! :(

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
Diarrhoea is a known side effect of Revolution (selamectin) and is normally self limiting, resolving itself after a few days (see quote below from prescribing information); keep an eye on Melvin and visit your Veterinarian if there is no improvement. Regards Dr Callum Turner DVM “Following treatment with Revolution, transient localized alopecia with or without inflammation at or near the site of application was observed in approximately 1% of 691 treated cats. Other signs observed rarely (≤0.5% of 1743 treated cats and dogs) included vomiting, loose stool or diarrhea with or without blood, anorexia, lethargy, salivation, tachypnea, and muscle tremors.” www.zoetisus.com/_locale-assets/mcm-portal-assets/products/pdf/revolution-prescribing-information.pdf

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Azul
Maine Coon
10 Months
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Tremors
Rapid breathing

My 10 month old Maine coon has been breathing fast and having intermittent tremors for a couple of months now. He has checked out normal through a cardiologist (echo and bubble study and chest x-ray). It just occurred to me what if it is the Revolution. He has no other exposure to plants or chemicals. Is it possible for the Revolution to continue to cause symptoms throughout the month and not just immediately after application?

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
Both tachypnea (rapid respiratory rate) and muscle tremors are known side effects of Revolution (selamectin) poisoning, these symptoms may occur for a period of time but are generally self limiting and resolve within a few days; I don’t know of month long presentations of these side effects in my experience. You could call the manufacturer (see second link) for information on this. Regards Dr Callum Turner DVM www.zoetisus.com/_locale-assets/mcm-portal-assets/products/pdf/revolution-prescribing-information.pdf www.zoetisus.com/contact-us.aspx

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Bella
Persian
1 Year
Serious condition
0 found helpful
Serious condition

Hello, I bathed my 1.5 year old cat and her 6 weeks old kitten with cisaflux and now they have started vomiting white foam like thing. Please advise that what can be done to make everything alright.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
Cisaflux (cypermethrin) is intended for use in dogs and is contraindicated in cats (there is a warning) since cats cannot process or eliminate cypermethrin; this is something that you should visit your Veterinarian about immediately, do not consider home treatment. Regards Dr Callum Turner DVM http://livein.ztsaccess.com/products/companion-animals/ectoparasiticides/cisaflux.aspx

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Wookie
Domestic long hair
4 Months
Moderate condition
1 found helpful
Moderate condition

Medication Used

Revolution
Ear mite

For 4 month old kitten having possible reaction to revolution also received eat mite medication ... Vet involvement is diffcult at this time ... What are potential medications to act against reaction ... Cat is not mine just trying to get additonal info for my young niece ... Thank you

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
There are different types of reactions which may occur after the use of Revolution (selamectin) in cats; depending on the type of reaction, the specific treatment would vary. Many times, there is just a wait and see approach if there are neurological signs like twitching etc… If there is some hair loss, bathe the area with a mild cat shampoo and monitor for regrowth. If there are hives, cetirizine at 5mg per day along with bathing may help. There is no single way to manage a reaction since there are many possible different reactions, if you have any further concerns you may reach out to the manufacturer if you have no Veterinarian close to home. Regards Dr Callum Turner DVM www.zoetisus.com/_locale-assets/mcm-portal-assets/products/pdf/revolution-prescribing-information.pdf

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Maui
Domestic shorthair
4 Years
Critical condition
0 found helpful
Critical condition

Has Symptoms

Fever
Fever Racing heart

Gave my 4 year old cat revolution. 4 days later. She is acting odd and lethargic. She doesn’t seem to know me and breathing or heart beating way to fast. Took to bet. She had 104 fever and blood shows heart problem. They think hypertrophic cardiomyopathy. Fever still with antibiotic. She doesn’t respond to me. Like before. Bet is very negative. Will she improve?

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
Lethargy and increased respiratory rates are noted side effects of Revolution (selamectin), however I cannot indicate whether the Revolution is the cause of the symptoms (normally symptoms present within a few hours) or due to another cause. Without examining Maui myself I cannot give you an indication of prognosis, it is a case of taking a wait and see approach to see how Maui responds to treatment. Regards Dr Callum Turner DVM www.zoetisus.com/_locale-assets/mcm-portal-assets/products/pdf/revolution-prescribing-information.pdf

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Norris
Domestic shorthair
3 Years
Mild condition
0 found helpful
Mild condition

Has Symptoms

Weight Loss
Lethargy
Licking
scratching

Hello,

I gave my 3 year old male can flea drops last week after he showed symptoms of having fleas. (This is the brand: http://www.petsathome.com/shop/en/pets/cat-flea-treatment/cat-spot-on-flea-repellent-drops-12-weeks?i=18&orderBy=3)

He has no signs of fleas anymore, but is still very lethargic, scratches himself a lot around the neck area and licks himself more than usual.

He is still eating and drinking normally, but has lost about 400g of weight. I initially thought it could be worms, but he is treated for ring worm and I haven't seen any signs in his stool. Could it be an allergic reaction?

Many thanks,
Maria

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
Some cats respond to topical flea medications with those signs, and if he isn't feeling well and is losing weight, it might be worth washing the product off with cat shampoo (I'm not sure how long ago you put the product on, but if it is less than 2 days, this may help). If he continues to lose weight or his skin is getting infected, it would be best to have him seen by a veterinarian, and get a flea product that may be a little more safe for him.

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Lily
dsh
10 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Disoriented; dilated pupils

Medication Used

Paradyne Selamectin Topical, Cats

Within 2-3 hours of administering the prescribed dose, our cat is disoriented and has a dopey look in her eyes. Breathing seems regular. Tried calling pet hospital they refer me to posion control. After 40 minutes no one answered. I need to know if I should take her to pet hospital now or wait until vet opens in the morning (9 hours from now)?

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
If Lilly will eat, even if it is decreased, and she isn't having tremors or seizures, you should be fine to wait until your clinic opens in the morning. Some topical medications will cause lethargy in some cats, and as long as you know that the dosage was correct, keep an eye for any further neurologic signs and have her seen if she is tremoring or seizing.

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Kiki
tabby
1 Year
Fair condition
1 found helpful
Fair condition

Has Symptoms

limp

I gave my cat Revolution for the first time yesterday. I changed revolution because I heard it was the best. Within one hour of administering my previously healthy, energetic 1-yr old cat was meowing a lot and not able to walk well with the hind legs. It has been 24 hours and although he has had moments of feeling better he is again limping and not using the right hind leg. He is eating and drinking although less amounts. Should I take him to the vet?

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
That is a very unusual reaction to Revolution, if that is what caused this problem for Kiki! I'm sorry that that is happening to him. I think it would be a good idea to have him seen by a veterinarian, to make sure that there isn't anything that they can do to speed up his recovery, and to make sure that nothing else is going on. I hope that he is okay.

Hello, how is your Kiki? I hope he is improving.

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Marbles
Calico
12 Years
Moderate condition
3 found helpful
Moderate condition

Has Symptoms

Panting,
panting, no appetite

My elderly cat was given a 90 day dose of Revolution at the vet today and is now panting off and on. She is drinking water and going to the bathroom but has no appetite. She is also diabetic.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
Revolution (selamectin) is a safe to use treatment which has been tested at ten times the normal dose on six week old kittens with no ill effects; however rapid breathing and loss of appetite are noted side effects of selamectin. You should keep a close eye on Marbles and visit your Veterinarian if there is no improvement after a few hours. Regards Dr Callum Turner DVM “Other side effects reported in cats and dogs include vomiting, diarrhea with or without blood, anorexia (decreased appetite), lethargy (sluggishness), salivation, rapid breathing, pruritus (itching), urticaria (welts, hives), erythema (skin redness), ataxia (incoordination), fever and rare instances of death.” www.zoetisus.com/_locale-assets/mcm-portal-assets/products/pdf/revolution-prescribing-information.pdf

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Brady
Dlh
4 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Weakness

I put revolution on my cat last Saturday morning
He went to sleep and got very lethargic. This went on thru Sunday & Monday I took him to the vet. He wasnt eating. They washed him. He's still sick. Blood work is showing high white cell count & high eso
He's weak & im
Worried

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
Some cats may be sensitive to selamectin (active ingredient in Revolution) which may cause symptoms including weakness and lethargy; in many cases the only course of action is to offer supportive and symptomatic care until the medication has been eliminated from the body. Regards Dr Callum Turner DVM

Hello, How Brady is doing since your original post?

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Soldier
Domestic long hair
8 Weeks
Fair condition
0 found helpful
Fair condition

Has Symptoms

Bald spot

Hi. My kitten was recently treated for poisoning by Revolution due his very low weight and a very bad misunderstanding! (He was way to young for it!) he had severe diarrhoea and vomiting as well as muscle tremors but my vet managed to cure him & he is 100% better now except just 2 days ago (a week after revolution was administered) i noticed a bald spot on his head. Its quite big now. Can it be related to the revolution poisoning. Stressing about my little boy, please help!

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
The prescribing information for Revolution (selamectin) states that: “Following treatment with Revolution, transient localized alopecia with or without inflammation at or near the site of application was observed in approximately 1% of 691 treated cats.” This means that it is possible that the alopecia is related to the application of Revolution, but I cannot say for 100% due to the low incidence rate. You should keep an eye on Soldier for the time being and visit your Veterinarian if the issue doesn’t resolve. Regards Dr Callum Turner DVM www.zoetisus.com/_locale-assets/mcm-portal-assets/products/pdf/revolution-prescribing-information.pdf

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Colin
tabby
7 Years
Moderate condition
1 found helpful
Moderate condition

Has Symptoms

Nausea

Medication Used

Vomiting

I gave my complete indoor cats, a 7 year old and a 17 year old, revolution last night. Today the 17 year old threw up a mass amount of clear liquid once and has been fine since. The 7 year old however has thrown up all day long. Every time he moves a little bit, he immediately hops down and has to throw up. Some has been food, most has been clear. He also seemed warmer than usual earlier and was shaking periodically. But that has stopped. He ate dinner and drank water and is sleeping right now, which is a definite good thing. I am concerned at the mass amount of vomit but relieved it is clear. I am wondering if this is a possible reaction to the revolution?
I can tell he just doesn’t feel well but I do not have the $ to go to the vet. I have subq fluids I can give if he doesn’t hold his food and water down tonight, he ate i/d food tonight. I am fresh out of cerenia though.
If this is an allergy what are the best ways to help him through the nausea and vomiting? Are there home remedies for nausea? Also if this is an allergy do I need to switch flea medication in the future?

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
Normally when cats have this reaction it is because they licked the application site on themselves or on each other; if this is the case it is really just waiting for the vomiting to stop and rinsing out the mouth. Vomiting is generally seen as a side effect with proper use in less than 0.5% of cases so it is unlikely that both cats would be affected, it is more likely they licked each other. Monitor them for now, but I cannot recommend you use any at home fluids as I don’t know if it is open, stored correctly, in date or you have sterile needles etc… Regards Dr Callum Turner DVM www.zoetisus.com/_locale-assets/mcm-portal-assets/products/pdf/revolution-prescribing-information.pdf

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Imogen
DOMESTIC
2 Years
Mild condition
0 found helpful
Mild condition

Has Symptoms

Vomiting
Bald spot

A dose of revolution (5-15lb -- Imogen's last recorded weight just over 5lbs)... Now has bald spot and has thrown up a few times. She had been eating some because this evening not very interested. I don't notice any other side effects. I'm concerned for her vomiting.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
The symptoms of localised alopecia and vomiting are noted as side effects in cats as disclosed on the prescribing information: “Following treatment with Revolution, transient localized alopecia with or without inflammation at or near the site of application was observed in approximately 1% of 691 treated cats. Other signs observed rarely (≤0.5% of 1743 treated cats and dogs) included vomiting, loose stool or diarrhea with or without blood, anorexia, lethargy, salivation, tachypnea, and muscle tremors.” In these cases we recommend that any remaining product to be rinsed off (but it would be absorbed and dry by now) and encourage Imogen to drink and eat with hydration being the most important factor here. If there is no improvement or you notice more concerning symptoms you should visit a Veterinarian. Regards Dr Callum Turner DVM www.zoetisus.com/_locale-assets/mcm-portal-assets/products/pdf/revolution-prescribing-information.pdf

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B
Siamese
5 Years
Serious condition
0 found helpful
Serious condition

Has Symptoms

scratching

I have 4 cats. A while back I applied to their skin Revolution (selamectin) in the correct amount. Only one of them, a 5 year old Siamese male, has been scratching a lot mostly at his head, face, neck, which prompted me to take him to the vet. He was diagnosed with Eosinophilic Granuloma Complex. He has never scratched himself before and none of the other cats are scratching themselves. He is now scratching himself constantly. He eats Wellness, Blue Buffalo and Halo. Tried food trials. For a while I didn’t give him any chicken but it didn’t seem to help. Have given him two shots of depomedrole since then but I really would not want to continue on that route. Going back over everything, it made me wonder if perhaps he had an allergic reaction to Revolution. Can cats develop EGC from Revolution?

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
Thank you for your email. EGC is an immune disorder in cats, and it can be unknown whata might cause it. It is unusual for that disease to develop from a topical appication of Revolution, but probably not unheard of. If might be best to switch to an oral form of flea/heartworm prevention for him. Your veterinarian can guide you in deciding approrpriate medication.

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Rayna
Ragdoll
14 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

scratching

I need to give my 14 year old cat Revolution, but am concerned about her weight, which is only 5.13 pounds. Is it okay for her to have the medication at such a low weight? also, she gets Depo Medrol shots every four months for allergies.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
There are various weight sizes of Revolution (selamectin) in cats including doses of 5lb or less and 5-15lb body weight; if you have concerns you should discuss with your Veterinarian before administration. Regards Dr Callum Turner DVM www.zoetisus.com/_locale-assets/mcm-portal-assets/products/pdf/revolution-prescribing-information.pdf

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Mia
tabby
3 Years
Mild condition
0 found helpful
Mild condition

Has Symptoms

Redness
Hair Loss

Medication Used

Selamectin

I applied a monthly revolution packet to my cat's posterior neck last Thursday night, before going out of town. When I returned last night, I noticed a patch of red, scabby/dry skin (it pretty much looks like an abrasion that is infected, but at the dry crusty stage) and hair loss at the application site (about quarter size). She has no other noticeable changes and the redness doesn't appear to have spread since then (about 12 hours). I don't remember her having this reaction before.

Note: it took me a few more tries than usual to empty the entire revolution packet onto her skin. Is it possible that this irritation is from me pressing too hard? Can you apply neosporin to cats? thank you for your help! I'm legit broke, but can figure out vet costs, if you think she needs it.

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
Thank you for your email. Some cats will have a local reaction to topical flea prevention, and that may be what is happening since you noticed the spot after you applied the Revolution. If Mia isn't scratching at the spot, and it doesn't get bigger, or more red, or more scabby, you should be able to monitor it for improvement. If it is getting bigger or more inflamed, or she is scratching or seems irritated by the area, she should be seen by your veterinarian. I hope that everything goes well for her!

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