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What is Revolution Allergy?

Revolution (also called selamectin) is a topical medication that is used for flea and heartworm prevention. While the product has been tested and is safe, some cats may experience a reaction to it where their immune system will overreact to an element of the medication, leading to allergy symptoms. While symptoms in cases of a reaction are usually mild, it is important to seek medical attention should you notice a reaction after administering the medication in order to ensure the best outcome for your cat.

When a cat is experiencing an allergy to Revolution, it is the result of their immune system overreacting to an element of the medication upon it having contact with their skin or being ingested.

Symptoms of Revolution Allergy in Cats

Symptoms of an allergy to Revolution are similar to those of other allergies. These include:

  • Watery eyes
  • Runny nose
  • Inflammation in their skin
  • Scratching, biting and/or licking his skin
  • Hair loss
  • Skin rashes
  • Hives
  • Respiratory issues
  • Lethargy


Medications to prevent fleas and heartworms in your cat are typically available in topical and ingestible forms. The topical medications will be applied to the back of your cat’s neck on his skin. Should your cat experience an allergy, it can present itself right away or within a few hours or days. The topical form of the medication will be administered to your cat once a month to prevent flea and heartworm infestation. Other products that protect your cat against fleas and heartworms include:

  • Advantage multi
  • Advantage/Advantage II
  • Frontline Plus
  • Comfortis

Causes of Revolution Allergy in Cats

The active drug in Revolution is selamectin. Revolution has been tested in studies using ten times the recommended amount without negative reactions occurring, however, an allergy or negative reaction, while rare, is possible. An allergy to Revolution occurs when the mast cells of your cat’s immune system mount an aggressive response to one of the components of the medication. The mast cells release a histamine which will lead to inflammation in the tissues it comes in contact with as they attempt to fight what they see as an intruder. The histamine that is released leads to the allergy symptoms your cat experiences.

Diagnosis of Revolution Allergy in Cats

Should you notice concerning symptoms in your cat after applying Revolution, you will want to take him to your veterinarian. After conducting a full physical examination, your veterinarian will ask you for information in regards to the symptoms you have noticed, when you first saw them and any changes you have observed. The skin symptoms your cat is experiencing will lead to your veterinarian taking a sample of his skin cells through skin scraping so that he can view them under a microscope to see if there are any parasites, yeast or bacteria present. Once those are ruled out, your veterinarian will consider possible causes of your cat’s symptoms.

A complete blood count and chemistry panel may be taken; should the specific white blood cell level be high it will point to an allergy being present in your cat. The results of the blood work will help eliminate other causes of the symptoms your cat is experiencing. Should your cat be experiencing respiratory problems, a radiograph may be taken so that your veterinarian can view his lungs and rule out illnesses like pneumonia or bronchitis.

Your veterinarian will likely ask you for information about the diet of your cat as well as any supplements and medications that he takes. Be sure to mention when you administered Revolution to your cat as this may help your veterinarian pinpoint the cause of his symptoms.

Treatment of Revolution Allergy in Cats

Your cat’s treatment will depend on the symptoms he is experiencing. Should your cat be experiencing breathing difficulties, these will be addressed immediately with oxygen therapy as appropriate. An antihistamine will likely be administered to decrease the inflammation your cat is experiencing. Unfortunately, antihistamines are not effective in all cats, so this may or may not impact your cat’s condition. The antihistamine may help with any respiratory system swelling as well as skin inflammation. Should your cat be experiencing skin symptoms, shampoos and topical ointments containing hydrocortisone may be recommended to give him immediate, though short term, relief. 

Corticosteroids (either injected or administered orally) are often very helpful though they have serious side effects when used over a long period of time. Should your veterinarian recommend corticosteroids, he will usually plan to monitor your cat’s blood chemistry levels to catch any potential issues as a result of the medication. If your cat develops a secondary bacterial infection due to their excessive licking and scratching, an antibiotic will be prescribed.

Recovery of Revolution Allergy in Cats

You will want to work closely with your veterinarian to ensure the best outcome for your cat. Should your cat react to Revolution, you will want to avoid giving it to him in the future. Fortunately, there are other options for flea and heartworm prevention for your cat and you can choose one of those for his protection. Your veterinarian may recommend follow-up appointments so that he can see how your cat is doing and make any necessary changes to his treatment.

Revolution Allergy Questions and Advice from Veterinary Professionals

5 Years
Serious condition
0 found helpful
Serious condition

Has Symptoms


I have 4 cats. A while back I applied to their skin Revolution (selamectin) in the correct amount. Only one of them, a 5 year old Siamese male, has been scratching a lot mostly at his head, face, neck, which prompted me to take him to the vet. He was diagnosed with Eosinophilic Granuloma Complex. He has never scratched himself before and none of the other cats are scratching themselves. He is now scratching himself constantly. He eats Wellness, Blue Buffalo and Halo. Tried food trials. For a while I didn’t give him any chicken but it didn’t seem to help. Have given him two shots of depomedrole since then but I really would not want to continue on that route. Going back over everything, it made me wonder if perhaps he had an allergic reaction to Revolution. Can cats develop EGC from Revolution?

Dr. Michele King, DVM
Dr. Michele King, DVM
479 Recommendations
Thank you for your email. EGC is an immune disorder in cats, and it can be unknown whata might cause it. It is unusual for that disease to develop from a topical appication of Revolution, but probably not unheard of. If might be best to switch to an oral form of flea/heartworm prevention for him. Your veterinarian can guide you in deciding approrpriate medication.

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14 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms


I need to give my 14 year old cat Revolution, but am concerned about her weight, which is only 5.13 pounds. Is it okay for her to have the medication at such a low weight? also, she gets Depo Medrol shots every four months for allergies.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
1978 Recommendations
There are various weight sizes of Revolution (selamectin) in cats including doses of 5lb or less and 5-15lb body weight; if you have concerns you should discuss with your Veterinarian before administration. Regards Dr Callum Turner DVM

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3 Years
Mild condition
0 found helpful
Mild condition

Has Symptoms

Hair Loss

Medication Used


I applied a monthly revolution packet to my cat's posterior neck last Thursday night, before going out of town. When I returned last night, I noticed a patch of red, scabby/dry skin (it pretty much looks like an abrasion that is infected, but at the dry crusty stage) and hair loss at the application site (about quarter size). She has no other noticeable changes and the redness doesn't appear to have spread since then (about 12 hours). I don't remember her having this reaction before.

Note: it took me a few more tries than usual to empty the entire revolution packet onto her skin. Is it possible that this irritation is from me pressing too hard? Can you apply neosporin to cats? thank you for your help! I'm legit broke, but can figure out vet costs, if you think she needs it.

Dr. Michele King, DVM
Dr. Michele King, DVM
479 Recommendations
Thank you for your email. Some cats will have a local reaction to topical flea prevention, and that may be what is happening since you noticed the spot after you applied the Revolution. If Mia isn't scratching at the spot, and it doesn't get bigger, or more red, or more scabby, you should be able to monitor it for improvement. If it is getting bigger or more inflamed, or she is scratching or seems irritated by the area, she should be seen by your veterinarian. I hope that everything goes well for her!

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