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- Heart murmur or abnormal rhythm
- Tires easily
- Generalized weakness
- Stunted size and failure to grow in puppies
- Respiratory difficulties
- Intermittent cough
- Bluish tinge to gums and other mucus membranes
- Fainting
- Abdominal swelling
- Ostium secundum – the hole occurs in the central part of the atrial septum; his is the most common type in dogs and humans
- Sinus venomous defect – the defect occurs in the top part of the atrial septum
- Ostium primum (sometimes called a partial atrioventricular septal defect) – the defect occurs at the bottom of the atrial septum close to the ventricle chambers
- ASD is more common in Boxers and Samoyeds
- Canine parents with ASD often pass it on to their children
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