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What is Deramaxx Poisoning?

Deramaxx is a brand name version of a non-steroidal anti-inflammatory drug (NSAID), Deracoxib, and is used to relieve post-operative pain or pain in canines who are afflicted with osteoarthritis. Although it is generally a safe medication when given as prescribed there is the possibility of serious toxicity if the dog overdoses on a large amount at once, if your dog has a sensitivity to it, or if it reacts to another chemical in the patient’s blood. You should contact your veterinarian as soon as possible if symptoms develop.

Deramaxx is a brand name version of a non-steroidal anti-inflammatory drug (NSAID), Deracoxib, designed to relieve pain in canines. NSAIDs have a high level of interactivity with other medications, including herbal remedies.

Deramaxx Poisoning Average Cost

From 63 quotes ranging from $200 - $2,500

Average Cost

$500

Symptoms of Deramaxx Poisoning in Dogs

Either a sensitivity to the Deracoxib that the Deramaxx is composed of or an overdose of the substance can cause damage to the kidneys, liver, or heart. 

  • Abdominal pain
  • Black tarry stool
  • Bruising
  • Dehydration
  • Diarrhea
  • Excessive urination 
  • Fatigue
  • Itching
  • Lethargy
  • Loss of appetite
  • Rash
  • Seizures
  • Vomiting, possibly bloody
  • Weight gain

Types

Deracoxib/Deramaxx is just one of several NSAID medications available, and each of them has the potential for toxicity if your canine has a sensitivity, if the amount ingested is too high, or if there are any interactions with other drugs. 

These are additional NSAIDs approved by the FDA for use in dogs, and the brand names they are known under.

  • Carprofen (Rimadyl,Novocox,Vetprofen, Carprieve, Quellin, Carprofen)
  • Etodolac (EtoGesic)
  • Firocoxib (Previcox)
  • Meloxicam (Metacam, Loxicom, Orocam, Meloxicam)

These are common over the counter NSAIDs for humans, and a few of the more common brands that use them.

  • Aspirin (Bayer, Bufferin, Excedrin)
  • Ibuprofen (Advil, Motrin)
  • Naproxen Sodium (Aleve)
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Causes of Deramaxx Poisoning in Dogs

NSAIDs like Deramaxx repress the enzyme cyclooxygenase (COX). This enzyme stimulates the production of many substances within the body, including the prostaglandins that contribute to pain and inflammation after cell damage has occurred. The repression of the enzyme reduces the amount of pain and inflammation, but it also reduces the other functions of the prostaglandins, such as protecting the stomach lining from acid, maintaining blood flow to the kidneys, and supporting platelet formation. When administered to your pet as prescribed by a veterinarian these medications are relatively safe, however certain circumstances such as overdose, oversensitivity to the drug, or reactions to other drugs, it can become fatal. If your pet develops symptoms of toxicity due to Deramaxx or similar NSAIDs, stop giving the drug and contact your animal’s veterinarian right away. 

Certain patients should not take Deramaxx or should be very closely monitored by the veterinarian. Disorders and conditions that can increase the likelihood of the medication to become detrimental instead of helpful:

  • Cardiac disease
  • Dehydration
  • Gastric ulcers 
  • Hepatic disorders
  • Hyperproteinemia
  • Pregnant or nursing dogs
  • Renal disease

Concurrent use of other NSAIDs or any form of steroids should be avoided as that can increase toxicity.

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Diagnosis of Deramaxx Poisoning in Dogs

Your veterinarian will need to get your pet’s full history from you, taking special note of the diet and any opportunistic eating as well any concurrent prescriptions or supplements that your dog is on. A complete blood count, biochemistry profile, and urinalysis are likely to be done at this time as well. This will help determine not only the concentration of the drug in the system, but also the functionality of the kidneys and liver. If due to a reaction from a prescribed administration of Deramaxx, such as use for osteoarthritis or post-operative pain, your veterinarian will likely have taken a baseline test prior to starting treatment to compare the current results to. This will give a clear picture of what changes have occurred since the treatment plan for the pain started. In many cases of Deramaxx toxicity a hospital stay will be required to monitor the patient’s liver and kidney functionality.

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Treatment of Deramaxx Poisoning in Dogs

Treatment for NSAID poisoning, such as you would see from a single overdose of Deramaxx, generally starts with instigating vomiting in the patient or gastric lavage, also known as gastric irrigation, at the veterinarian’s office. This proceedure is done to remove as much of the medication from the digestive system as possible before it can be absorbed into the blood and is usually done under general anesthesia. Activated charcoal will be administered after the the stomach contents are removed to prevent reabsorption of any remaining toxin. Any required supportive treatment will be administered at this time as well. This can include IV fluids, pain medication, and gastro protective medications. The fluids are particularly essential to the patient’s healing as the potential for renal failure can be exacerbated by even mild dehydration. Prognosis of this condition is dependant on the amount eaten, the speed of initial diagnosis and treatment, and the size of the dog.

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Recovery of Deramaxx Poisoning in Dogs

Once your pet has returned home from the hospital a calm and quiet environment to recuperate in will help ensure a speedy recovery. Patients recovering from anesthesia may have difficulty with coordination and muscle control when they first get home, and they are often disoriented. Isolation from other pets and from children is often wise until the anesthesia has fully cleared your companion’s system. Any medications that were prescribed by your veterinarian should be given as directed. It is vital that fresh water be available for your dog at all times as even minor dehydration has a high probability of making the situation worse. Dogs diagnosed with Deramaxx overdose will likely need several follow-up appointments to check their liver and kidney function.

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Deramaxx Poisoning Average Cost

From 63 quotes ranging from $200 - $2,500

Average Cost

$500

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Deramaxx Poisoning Questions and Advice from Veterinary Professionals

Need pet health advice? Ask a vet

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Ask a Vet

dog-name-icon

dog-breed-icon

Australian Shepherd

dog-age-icon

Sixteen Years

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Unknown severity

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0 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Unknown severity

Has Symptoms

None

This is stupid, but I wasn't thinking this morning when I was giving him his usual dose of 1 1/2 pill. The pills are 25 mg. I took them by mistake, dummy that I am. I should have no problem should I? I weigh 121 pounds if that helps. Thank you.

July 25, 2020

Owner

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Dr. Michele K. DVM

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0 Recommendations

Thank you for your question. You would be surprised how often that happens, and it isn't stupid. I cannot give you medical advice, however, with my license. It would be best to contact your physician and ask if you need to take any actions. I hope that all goes well!

July 25, 2020

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Bruiser

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Golden Retriever cross

dog-age-icon

9 Years

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Moderate severity

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0 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Moderate severity

Has Symptoms

Arthritis

Hi we have just started on half a Deramaxx every 24 hours, but we pay over $6 a pill and I waa wondering is there a cheaper or generic version on this med? Oh and I am in Canada. My dog is 34.6 kg. Thanks

May 15, 2018

Bruiser's Owner

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recommendation-ribbon

3320 Recommendations

There are cheaper places to purchase Deramaxx (deracoxib), there are online pharmacies which will sell cheaper than $6 per tablet; PetSmart in the US (not in Canada) will sell 100mg tablets from US$3.10 per tablet (or CA$4,00), there are other options but I am not familiar with Canadian online veterinary pharmacies. Regards Dr Callum Turner DVM www.petsmart.com/dog/pharmacy/rx-medication/deramaxx-chewable-tablet-for-dogs-5274380.html

May 16, 2018

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Molly

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Husky

dog-age-icon

7 Years

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Fair severity

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1 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Fair severity

Has Symptoms

Post Surgery

Molly, 7-8 yr old husky/Akita. Tplo and ccl surgery about 10 days ago. She has not eaten much. Last 4 days eaten nothing. Still drink water. Took her back to the vet, told that she has high potassium and low soldium. She was on Deramaxx. Please help. Can’t afford another 4 grand to leave her the vet for a night. Please, pleas

Feb. 28, 2018

Molly's Owner

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3320 Recommendations

There are various possible causes for the symptoms you are seeing and for the high potassium and low sodium found by your Veterinarian; none of the symptoms themselves are diagnostic of one particular issue and without examining Molly I cannot recommend any course of (prescription) therapy. Hydration is important and ensuring that other maintenance needs are met, I cannot think of anything you can do at home to help her at this time. Regards Dr Callum Turner DVM

Feb. 28, 2018

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Scout

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lab

dog-age-icon

12 Months

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Fair severity

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2 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Fair severity

Has Symptoms

Tarry Stool
Diarrhea

My lab was nuetrered on Friday, Saturday and Sunday he was accidently given double doses of deramax. His stool is runny and very dark. I was told to give him OTC antacids and fluids. Should I be more concerned? It is now Monday night and I haven’t given him a dose all day.

Feb. 12, 2018

Scout's Owner

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Dr. Michele K. DVM

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1611 Recommendations

Thank you for your email. A small overdose of an NSAID can cause stomach upset, gastric bleeding, and kidney damage. If his stools improve, and his appetite is normal, you should be okay to continue the treatment that your veerinarian has recommended. If he starts vomiting, continues to have dark stools or diarrhea, or has a decrease in appetite, it would be best to have him examined, and possible lab work run, to determine his health status and make sure that he is okay.

Feb. 13, 2018

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Tonto

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chihuahua mix

dog-age-icon

4 months

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Fair severity

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2 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Fair severity

Has Symptoms

My dog took a 12mg dose of Deramaxx about three hours ago. The bottle perscribed 1/4 of the pill, and we gave him the first amount but the other three fourths were also ingested by him. He is not displaying any symptoms, and actually is running around and such. Even went potty, ate and drank normally. Will he be okay?

Dec. 13, 2017

Tonto's Owner

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recommendation-ribbon

3320 Recommendations

A dose of 12mg shouldn’t cause much of a problem for Tonto, but you should keep a close eye on defection as gastrointestinal symptoms are the most common problem with overdosing but 12mg is pretty close to a therapeutic dose for a dog Tonto’s size. Keep an eye on him and visit your Veterinarian if you notice any symptoms. Regards Dr Callum Turner DVM www.fda.gov/downloads/animalveterinary/products/approvedanimaldrugproducts/druglabels/ucm050385.pdf www.petpoisonhelpline.com/poison/deramaxx/

Dec. 13, 2017

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Moe

dog-breed-icon

Shih Tzu

dog-age-icon

8 Years

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Critical severity

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0 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Critical severity

Has Symptoms

Thirsty, Loss Of Appetite, Wight Lo

I went out for errands and came back to a broken up bottle of Derramax that had been on a desk, normally in the drawer. Bottle was almost full, somewhere around 27 pills of 25mg We had company over so the boys and I were in a different room. One of the boys, born blind takes Durramax for a back problem and it has saved his life, of what was constant, crying pain. He has been taking 12.5 dose every day for almost 2 years. At 13 his test results have all been great. Out of the 4 dogs, I had no idea which one or if all of them ate it, didn't know what to do but thought I would wait and see if anyone seemed ill. It wasn't unusual to see a puddle of watery substance from the older Blind one with his treachea issue (that was more an enlarged heart issue) but thinking back, it could have been one of the other 3 that can see and jump up on the desk. Nothing was really noticed in the first week or two, then we went out of town, noticed he was thirsty a lot, but seemed good otherwise. A couple weeks later I noticed the weight loss, the more time he lays away from us. I can't help but kick myself (very very hard) for not rushing them in to vet that night. It would have been around 3 or 4 hours after ingesting. Would it have helped at all, was it the damage is done, just a matter of time? We are at 9 weeks since ingestion and his last test results went from Creatinine 3.9 on 2/9 to 4.8 on 2/24 Bun was 80 but went down to 55; Bun ratio 20.5 to 11. Did he have a chance to recover??, or just a chance to have lived, just shorter of a life than his birth brother he will leave behind also.

dog-name-icon

Eeyore

dog-breed-icon

Staffordshire Bull Terrier

dog-age-icon

6 Years

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Critical severity

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0 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Critical severity

Has Symptoms

Not Eating Not Moving Vomiting

DERAMAXX KILLED MY DOG!!! DIED WITHIN 4-6 HOURS OF TAKING IT!!! I AM BEYOND GRIEVING AND SO UPSET THAT MY VET HAS PRESCRIBED HIS DEATH AND I PAID THEM TO BASICALLY KILL HIM!!! SOO UPSET WASNT GIVE ANYTHING WITH HIS PRESCRIPTION LIKE YOU AND I WOULD GET WHEN WE GET PRESCRIPTIONS AND I SEE WHY NOW... IF I WOILD HAVE HE'D BE ALIVE!!! DERAMAXX DERAMAXX DERAMAXX KILLED MY dog ... DO NOT GIVE IT TO YOUR DOG ITS COMPLETE POISONING AND IF YOU GIVE YOYR DOG EVEN THR SMALLEST AMOUNT YOU ARE POISONING YOUR DOG AND A 99.99% CHANCE YOUR DOG IS GOING TO DIE!!!

dog-name-icon

Buddy

dog-breed-icon

Labrador Retriever

dog-age-icon

11 Years

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Serious severity

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0 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Serious severity

Has Symptoms

Black Tar Stools, Gained Weight
Fatigue, Bruising, Loss Of Appetite

Three weeks ago my dog Buddy went to the vet because he was having problems with his hips. He is a black lab. The vet gave him some medicine for inflammation and Deramaxx 75mm for pain. He has taken it before mostly in the summer cause swims so much. He was suppose to get a half a tablet once a day and the other medication twice a day. We went back to the vet 10days later because he was getting worse. He was falling and could barely walk. She thought the other meds just didn’t work for him and started him on Adequan injects for his hips. I realized over the weekend that’s I was giving him a half of tablet twice a day with the other medication. tBuddy barely moved all weekend and did not eat anything. Itook him back to the vet on Tuesday and told her about the mistake with the dosage of the seremaxx. She checked his heart it was rapidly beating. It was rapid in the Friday appointment too. She did an ultrasound and found he had fluid in the sack around his heart and usually meant there an underlining reason usually cancer. She sent us to the ER hospital to drained the fluid around his heart. They did an echocardiogram the next day and an ultrasound and did not find any mass or tumor. They did see fluid in his abdomen and drain that too His red blood cells and platelets were low so he then he got a blood transfusion. He developed a fever and it was hard for him to breath so they put him on oxygen. This was all over 2-3days. I kept asking could this be the Deramaxx due to the extra dosage he was given for 10 days? They said that would not cause the systems he was having plus his kidney was fine. Toward the end the third day, he had some fluid in his liver and the fluid in his heart came back. They were able to drain the heart and he had some blood in his urine. We ended up putting him down before he got any worse and suffering. After I read the symptoms of a Deramaxx overdose he had almost all of them. I guess my question is could the toxins from the Deramaxx cause fluid around the heart?? Sorry for the long message..

dog-name-icon

Bebe

dog-breed-icon

Maltese

dog-age-icon

4 Years

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Serious severity

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0 found helpful

pill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filledpill-rating-filled

Serious severity

Has Symptoms

Disoriented,Limping,Lethargic

My 6-7lbs 4yr old maltese was given Demaraxx for strained wrist. We gave 1/2 table of 12mg for 3 days 24 hrs apart. Her front wrist is better but now she is 'limping' on her back leg (same side), lethargic, not able to eat or want to eat, acting disoriented and wobly when i make her stand on her 4 paws. could demaraxx is such short duration have caused this? maybe liver or kidney damage? no list of side effects was given to me when demaraxx was prescribed. i didn't know it was such as potent drug that some owners report even death!! is toxicity reversible? it's been over 24hrs since i last gave her so it's already in her system. Could something like 'silica 6c' help her system pee it and poop it out faster?

Deramaxx Poisoning Average Cost

From 63 quotes ranging from $200 - $2,500

Average Cost

$500

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