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- Nausea
- Anorexia
- Weight loss
- Lethargy
- Blood in the urine
- Increased thirst and urination
- Vomiting and diarrhea
- Renal cell carcinoma
- Transitional cell carcinoma
- Anaplastic carcinoma
- Lymphoma
- Hemangiosarcoma
- Anaplastic sarcoma
- Nephroblastoma
- Biochemistry – which may show an elevated level of urea and creatinine in cases where renal failure has begun to occur
- Urinalysis – which may show protein in the urine due to decreased ability of the kidneys to metabolize the molecule and hematuria
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