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- Dizziness
- Irregular heartbeat (arrhythmia)
- Rapid heart rate (tachycardia)
- High blood pressure (hypertension)
- Altered level of consciousness (obtundation)
- Central nervous system depression which presents as decreased rate of breath, decreased heart rate, complete loss of consciousness, coma, and death
- Shock such as effects on the body after electrical shock or anaphylactic reaction
- Infection that has become severe
- Restriction of airway
- Lung disease
- Dehydration
- Medication overdose
- Chest wall damage
- Central nervous system disease
- Trauma
- Diaphragmatic hernia
- Drugs causing respiratory depression
- Respiratory fatigue
- General anesthesia (hypercapnia is secondary to anesthetic-induced hypoventilation)
- Other problems during anesthesia like equipment malfunction or accident
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