Methionine Poisoning Average Cost

From 48 quotes ranging from $300 - 3,000

Average Cost


First Walk is on Us!

✓ GPS tracked walks
✓ Activity reports
✓ On-demand walkers
Book FREE Walk

Jump to Section

What is Methionine Poisoning?

Methionine is a naturally occurring amino acid that is also approved as a treatment for urinary stones in dogs. Methionine is a urine acidifier, so it can prevent the formation of struvite stones which are caused by an overly high alkaline content in the urine. It also neutralizes the acid base content of dog urine making it less damaging to grass.  Methionine supplements for dogs, called dl-methionine, comes with brand names like Metio-Form and Ammonil. The same supplement is also found in many lawn-saver dog treats and biscuits. In this context, the side effects and dangers of overdose may be less well labeled than on a veterinarian prescription, so it’s important to read all the ingredients carefully. 

Medication containing methionine should be avoided if your dog has liver, kidney or pancreatic disease, or urate urinary stones which are caused by overly acidic urine. If your dog is already on a diet to increase urine acidity, this drug is also contraindicated unless it is specifically recommended by a veterinarian. Methionine is safe for dogs at the recommended dosage, but it can still cause side effects like lack of appetite, upset stomach, and vomiting or diarrhea. These side-effects should always be analyzed by a veterinarian. Overdose and toxicity will result in CNS systems including poor coordination, staggering and eventually seizures. Cyanosis, which is bluish discoloration of the mucous membranes, may also be present. Dogs with methionine toxicity will need immediate veterinary attention. Most dogs will recover with treatment, however a severe overdose of methionine could be fatal.

Methionine supplements are given to dogs to reduce urinary stones and make dog urine less damaging to the grass. Overuse and accidental overdose can result in methionine poisoning with vomiting, diarrhea, and dangerous CNS symptoms.

Book First Walk Free!

Symptoms of Methionine Poisoning in Dogs

These are some of the signs of methionine poisoning. You should discuss even mild symptoms with a veterinarian.

  • Nausea
  • Vomiting
  • Diarrhea
  • Loss of appetite
  • Pale or blue looking mucous membranes (cyanosis)
  • Lack of coordination
  • Staggering
  • Seizures


These are the most common types of methionine.

  • Metio-Form
  • Ammonil
  • Doctors Foster & Smith Law Guard Treats
  • Other dog biscuits aimed at limiting damage to grass

Causes of Methionine Poisoning in Dogs

These are some of the risk factors associated with methionine poisoning.

  • Giving dogs more than the recommended dose
  • Accidental overdose (leaving the bottle open, dog chewing through the bottle)

Diagnosis of Methionine Poisoning in Dogs

Methionine poisoning will be diagnosed based on the symptoms and a history of methionine ingestion. A list of your dog’s medications may be helpful, especially if you are not sure what is causing your dog’s symptoms. If you think your dog ingested a large amount of methionine tablets, or another unknown substance, bring the packaging with you so the veterinarian can read the list of ingredients. A physical examination may show signs of ataxia or poor muscle coordination with severe overdose. Urinalysis will reveal a high acidic content. As the condition progresses, your dog may have a musty odor to the breath as methionine metabolism can produce volatile mercaptans.

Treatment of Methionine Poisoning in Dogs

With mild toxicity from overuse, the veterinarian may simply discontinue methionine supplements or reduce the dosage. Severe overdose will need symptomatic treatment until the methionine has been metabolized and excreted from your dog’s system. The veterinarian will give your dog IV fluids as well as steroids to stimulate respiration and medications to protect the gastrointestinal tract. Seizures will be controlled with phenobarbital or another anti-seizure medication like diazepam. The dog will need to stay in a veterinary hospital until the effects of the drug have passed and the veterinarian has ensured that the CNS system is responding normally.

Recovery of Methionine Poisoning in Dogs

Most dogs will recover from methionine poisoning with veterinary treatment. However it’s important to get treatment since seizures and other CNS symptoms can be fatal. To reduce the chance of exposure, store methionine tablets in a dog-proof container, preferably in a high place that your dog cannot reach. This is especially important because chewable methionine tablets often taste good to dogs. If the dog is able to chew open the container and access the tablets, as many as 350 may be ingested at one time.

To avoid accidently giving your dog too much methionine, read the labels of anything you give your dog, even treats and dog biscuits. Don’t use grass saver biscuits if your dog is on a prescribed dose of methionine for urinary stones, or even a high acid diet. Never give more than the recommended dose of any product containing methionine. If you forget a prescribed dose, give it as soon as you remember, but if it is too close to the time of the next dose, it’s better to skip a pill than give your dog two doses at once. Never give your dog extra doses unless it’s recommended by a veterinarian.

Methionine Poisoning Questions and Advice from Veterinary Professionals

Tibetan Terrier
5 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Frequent Urination

Our dog has large Struvite stones but will not eat the hills prescription food. Wanted to get some of these tablets and put her on a raw diet, but not sure if I should get the 200 or 500 mg tablet

Dr. Michele King, DVM
Dr. Michele King, DVM
873 Recommendations
Without knowing more about Alice, I can't recommend a treatment for her. A raw diet will not make a difference in the pH of her urine to a reliable level, but there are other brands of dissolution diets that you may be able to try. The dosage of medication depends on her weight, and your veterinarian can give you more guidance on which would be the best alternative to try and avoid surgery.

Add a comment to Alice's experience

Was this experience helpful?

5 Years
Fair condition
0 found helpful
Fair condition

Has Symptoms


I have a 50 lb dog that has eaten almost an entire box of these lawn saver biscuits. The recommended dose for his size is 1.5 biscuits....I know we're probably going to have some stomach issues, but am not sure how quickly or how long I should be monitoring him for serious issues. He seems fine at the moment.

Dr. Michele King, DVM
Dr. Michele King, DVM
873 Recommendations
That much methionine may cause more than stomach issues - a large overdose can cause seizures, and death. Salami should be taken to your nearest emergency clinic as soon as possible. I'm not sure when he ate them, but a veterinarian will be able to start supportive therapy and monitor him for toxic effects. he may need to be on IV fluids to flush the toxin from his system.

Add a comment to Salami's experience

Was this experience helpful?

4 Years
Fair condition
1 found helpful
Fair condition

Hi I am thinking about giving my Greyhound Tess naturvet grass saver. As she is killing all our lawn. She weighs 26kgs is 4 years old and is in good health. I am wondering if this product is safe. I would hate to hurt her for the sake of green grass.
Her diet is mainly premium dry dog food along with fresh eggs and mince steak.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
2313 Recommendations
If Tesz is otherwise healthy, there should be no issues using a product like this within the stated dose; if you suspect that Tesz may have some kidney or liver issues it would be best to consult with your Veterinarian even if you have general questions. It may also be worth speaking with your Veterinarian to discuss other possible issues. Regards Dr Callum Turner DVM

Add a comment to Tesz's experience

Was this experience helpful?