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- Drooling (some dogs who are particularly anxious about the car ride may begin to salivate before they even get in the car)
- Physical shaking
- Excessive panting
- Yawning (when nervous or anxious dogs yawn, it can be in an effort to calm themselves and can be seen as a sign of stress)
- Vomiting
- Whining or yelping
- Showing uneasiness
- Showing reluctance or inability to move
- Diarrhea
- The eyes may be sensitive to the motion seen as the car moves
- Skin receptors on the feet are confused by the movement
- Joints and muscle receptors are tracking the change in balance which may be agitating
- The central nervous system (brain and spinal cord) is confused, leading to mixed up signals
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