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- Dry and flaky skin
- Loss of appetite
- Vomiting
- Diarrhea
- Lack of energy
- Pyrethrins
- Pyrethroids
- Etofenprox
- Fipronil
- Methoprene
- Methylcarbamate
- Imidacloprid
- Amitraz
- Selamectin
- Nitenpyram
- Fluralaner
- Sarolaner
- Lotilaner
- The hypersensitivity towards the main ingredient
- An over-reactive immune system
- Afoxolaner causing skin irritation to the sensitive skin of the dog
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