Skin Blisters and Pustules in Dogs
Written By Darlene Stott
Published: 12/02/2015Updated: 03/05/2021
Veterinary reviewed by Michele K.
Skin Blisters and Pustules in Dogs - Symptoms, Causes, Diagnosis, Treatment, Recovery, Management, Cost
What are Skin Blisters and Pustules?
Cancer, bacteria, and inflammation are just a few of the conditions that may cause secondary skin complications which can result in skin blisters and pustules. Most of the skin conditions that affect dogs are visible to the eye. As well, your pet will surely let you know of his discomfort because skin irritations can be painful. It is important to address a skin condition promptly in order to eradicate the underlying cause, and return your pet to his normal state of health.
Skin blisters and pustules result from various causes, and can lead to extremely serious complications. Bacterial infections can be the source of severe outbreaks of the skin. Also known to have an effect on the skin are autoimmune diseases. Skin eruptions can evolve to a life-threatening state. If your dog is suffering from a skin condition, a visit to the veterinarian is crucial.
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Average Cost
$550
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Symptoms of Skin Blisters and Pustules in Dogs
Skin blisters and pustules can cause much anxiety for your pet. Prompt diagnosis of the reason for the outbreak is necessary to prevent the skin condition from getting out of hand. Your dog may exhibit the following signs and symptoms indicating a serious problem with the skin:
  • Warm, humid areas, such as folds in the neck, may appear red and ulcerated
  • Pressure points, like the elbow, may have welts or scabs
  • Ulcers can also emerge around the eyes, in the ears, and on the footpads, anus, groin, or axillae (armpits)
  • Blisters can develop in the mouth and also on the skin around the nails
  • There may be scaling of the skin, hair loss, or bald patches
  • Yellow pustules or sacs of fluid may secrete blood or pus and turn crusty
  • There might be an odor no matter how much you clean the area
  • Your dog may display signs of pain
  • Depression
  • Lack of appetite
  • Fever
  • Pruritus (inability to resist licking, scratching, or attempts at self-harm in an effort to stop the irritation and itch)
Types
Skin blisters and pustules can appear in an acute form, and may at times resolve (for a short period) on their own. In all cases, treatment is recommended in favor of resolution because a skin condition can lead to life-threatening circumstances. Additionally, removing the cause of the problem is necessary for a cure or control of the condition.
  • Pyodermas
    • Caused by a bacterial skin infection
    • Presence of yellow pustules that can ooze and itch
    • Mostly found on the trunk area, obese dogs or dogs with short faces are predisposed to infection in skin folds
    • Also found on toes, callouses on feet, and the abdomens of puppies
    • Not contagious to other pets or to humans
  • Skin Fold Dermatitis
    • Bulldogs are prone
    • Skin becomes red
    • Irritation might be found on the lips, face, and vulva
    • May progress with severe complications if left untreated
  • Cutaneous Lymphoma
    • This is a rare type of skin cancer
    • Displays with itching ulcers, redness, and nodules
    • Unfortunately this skin condition may not respond to treatment
Autoimmune Skin Conditions
  • Pemphigus Foliaceus
    • Akitas are prone
    • The skin around the nails can be affected
    • Ulcers may also be found in the ears, eyes, footpads and groin
  • Pemphigus Vegetans
    • Presents with chronic oozing and pus
    • Is more prevalent warmer sunny climates
    • Sun is a potential trigger
  • Pemphigus Vulgaris
    • Appears with fluid-filled blisters
    • Become open sores as the blisters rupture easily
    • Found in mouth, nostrils and around anus
  • Pemphigus Erythematosus
    • There will be scaling of skin
    • Irritation begins with redness and crusty patches
    • There may be hair loss specifically on nose
  • Bullous Pemphigoid
    • Presents with welts first
    • Next stage is sacs of clear fluid
    • Can be very itchy
    • The most common places it is found are the mouth, axillae (armpits) and groin
Causes of Skin Blisters and Pustules in Dogs
Skin blisters and pustules can occur for a variety of reasons, some of which are listed below:
  • Staphylococci bacteria over colonizes
  • Warm, moist areas can develop a high bacteria count
  • Skin conditions can be secondary to allergies or parasites
  • In the case of an autoimmune disease, the body attacks the immune system
  • Healthy cells are mistakenly attacked resulting in separation of skin
  • Pyodermas can result from damage to the skin like tumors, urine scalding or bite wounds
  • Medications for illnesses such as liver disease or cancer can cause an immunosuppression that leads to a skin condition
  • Genetics may play a role in problems with the epidermis
Diagnosis of Skin Blisters and Pustules in Dogs
The diagnosis of skin blisters and pustules can be complex. Identification of the underlying cause is paramount to the resolution of the skin issue. The veterinarian will need a complete history, as detailed as possible, in order to begin the diagnostic process. The veterinarian will want to know the following information:
  • Specifics on your pet’s diet (brand of food, treats)
  • Medications your dog may be taking
  • Grooming products used (bring labels for analysis)
  • Recent illnesses
  • Travel history
The appearance and location of the blisters or pustules can provide a clue to the type of skin condition. However, the veterinarian will also need to perform certain tests to definitively diagnose the lesions. To begin, it is possible that blood tests and allergy tests will be ordered.
A skin biopsy may be done. It is called a punch biopsy and involves taking a small round block of skin. The biopsy may be done using a local anesthetic, but if your dog is nervous or stressed, or if the biopsy involves the face or nose, sedation or a general anesthetic will be suggested. Needle aspirate cytology used to examine cells, and skin scraping, in order to exclude causes like parasites, may also be performed.
Culturing the skin, in an attempt to grow and identify bacteria, along with a fungal culture and adhesive tape prep (to examine cells, yeast or other abnormalities under the microscope) are additional tests that may be performed.
Treatment of Skin Blisters and Pustules in Dogs
Treatment will involve the resolution of the underlying cause if needed, as well as a variation of methods depending on the type of skin condition.
In the case of an autoimmune issue, corticosteroids, which are drugs that lessen the efforts of the immune system to attack, will be given along with other immunosuppressant medications. It should be noted that depending on the skin condition; some immunosuppressants can be given during flares only, once the initial problem is under control. An autoimmune related skin condition is rarely curable but may be managed quite well with medication.
In instances of pyodermas, 3 to 4 weeks of antibiotics may be prescribed. The antibiotics might be in oral and topical form. Bathing with a medicated shampoo 2 to 3 times a week is required, and in severe cases a daily bath may be vital to a positive outcome.
Included in the treatment protocol may be anti-inflammatories to reduce swelling and pain, acupuncture, light therapy or a dietary overhaul.
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Recovery of Skin Blisters and Pustules in Dogs
The recovery of a serious skin condition is never a quick process. For example, healing of pyodermas can take up to 8 to 12 weeks. However, a mild improvement should be evident within 14 to 21 days of the start of treatment. Recurrent cases are possible and sometimes will need a staphylococcal vaccine in order to see results.
Attention to grooming is essential. The services of a professional groomer should be sought out. Removal of hair, because of the likelihood of trapping bacteria, is key to avoiding a recurrence of the problem. Continual use of oral and topical antibiotics may be necessary for some time. The use of bandages or an Elizabethan collar could be recommended by the veterinarian to lessen the licking and biting that your dog might want to do.
With the use of corticosteroids for autoimmune related skin problems, you will need to be aware of possible side effects. Changes in appetite (decrease or increase), panting, increased drinking of water and thus, more urination, vomiting, and inactivity may be evident in your dog’s behavior. Consult the veterinarian promptly to address the side effects. Avoid direct sunlight with skin problems diagnosed in the pemphigus family of conditions.
Never stop antibiotics or ointments prematurely. Frequent check-ups with the veterinary caregiver are part of the recovery (may include blood tests and urinalysis to monitor side effects of the therapy), as is diligent skin care at home.
Skin Blisters and Pustules Average Cost
From 42 quotes ranging from $300 - $1,500
Average Cost
$550
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Skin Blisters and Pustules Questions and Advice from Veterinary Professionals
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Pekingese
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Thirteen Years
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My pet has the following symptoms:
Left Ear Hurting Bad I Can See Clear Bumps. Swollen
Can i help him or is this infection need s vet
Jan. 15, 2021
Answered by Dr. Sara O. DVM
0 Recommendations
Hello this infection really needs to see a vet. You can try over the counter ear cleaners to see if it helps but most of the time your dogs really needs to see your vet.
Jan. 16, 2021
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pit mix
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Two Years
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3 found this helpful

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3 found this helpful

My pet has the following symptoms:
Itchy Sores And Blisters On The Vagina
She is constantly itching and itching at the at the blisters on her vagina it gotten worse it didn't start out that with that many it just started out with the few
Jan. 14, 2021
Answered by Dr. Maureen M. DVM
3 Recommendations
Hi, Sorry about that. This could be a bacterial skin infection or viral. I'd advise you please visit the vet for some anti-inflammatory and antibiotics before it gets worse. She may need to have a collar on to prevent her from licking the area as it aggravates the already inflamed area.
Jan. 14, 2021
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Chihuahua mix
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Two Months
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5 found this helpful

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5 found this helpful

My pet has the following symptoms:
Redness
little pimple like bump on his private. he is acting normal.
Dec. 29, 2020
Answered by Dr. Linda S. MVB MRCVS
5 Recommendations
Hi there, That looks like a little pustule (bacterial infection) which may have been caused by e.g. an insect bite or him scratching his skin by mistake. This small lesion may respond to saline washes but keep an eye as, if it won't heal, we may need to issue antibiotics. Ensure he cannot lick it by using a buster collar.
Dec. 29, 2020
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Pit Bull
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Four Months
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4 found this helpful

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4 found this helpful

My pet has the following symptoms:
Blister
My dog has a rash with blisters and sores on her back thigh. She also has patches of missing hair and she’s really easily. She constantly bites the growing patch. She seems tired a lot.
Dec. 13, 2020
Answered by Dr. Linda S. MVB MRCVS
4 Recommendations
I'm sorry to hear your puppy has this issues. There are several possible causes for these signs including mange, a flea allergy, a food or environmental allergy, a primary bacterial infection etc. The lethargy is a concern and may indicate a more serious infection. She needs to be seen by your vet who can prescribe the most appropriate treatment which may include antibiotics, anti itch medicine and a medicated wash. Prevent self trauma with an e collar and clean the skin with salt water.
Dec. 13, 2020
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Beagle
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Nine Years
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2 found this helpful

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2 found this helpful

My pet has the following symptoms:
Open sore, saw it when we were playing, it doesn’t appear to be bothering him
Dec. 6, 2020
Answered by Dr. Sara O. DVM
2 Recommendations
Hello, You can clean this area with soap and water and apply triple antibiotic cream to this area. It is best to leave this open and not cover it, this will help it heal quicker.
Dec. 6, 2020
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Hovawart
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Koko
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14 Months
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0 found this helpful

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My pet has the following symptoms:
Pustules
Sores
Painful Blisters
So my new rescue dog has developed some blisters filled with pus around the edges of his paw pads. It’s very sore and we don’t know what that is. Could it be we walked him too much? The pavement wasn’t hot when we walked him so I know they’re not burns. Vet is treating it with anti inflammatory but I spotted more blisters coming up. No pictures on google look like what he has so I’m lost as to what caused them.
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Siberian Husky
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Chester
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2 Months
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My pet has the following symptoms:
Hair Loss
Red Bumps
Hi my 2 month old husky pup has reddish swelling around his mouth that has hardened. Also the hair around that region is thinning. He doesn’t seem to be in pain but I am worried if it is anything serious.
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Mastiff
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Captain
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5 Years
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My pet has the following symptoms:
Red Bumps Hair Loss Pus
I have a 5 year old Neapolitan mastiff mixed with a boerboel mastiff. The blisters started on his feet and mouth area. We changed his food around 5-6 times. It didn’t seem to help and the blisters were moving up his legs and onto his belly. We now feed him grilled chicken and carrots only. But the blister just seem to be getting worse. We took him to the vet and he was on antibiotics for about 3 months, but still the blisters are all over his body and don’t seem to be dying down. I can tell that he is still in a lot of pain, he is very lethargic and sleeps more than usual, he also does not seem happy. If anyone can recommend a good shampoo or diet, or literally anything that would be amazing. Our vet says it’s due to allergies, but nothing is working and I want him to feel like himself again.
Skin Blisters and Pustules Average Cost
From 42 quotes ranging from $300 - $1,500
Average Cost
$550
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