Lola’s owner will need to continue cleaning the wound and the surrounding area from the discharge and monitor the puncture for any signs of infection in the wound or surrounding tissues. What is the best way to clean a puncture wound in a dog? You should follow any instructions your veterinarian gives you regarding wound care and cleaning. Some bite wounds will be sutured, some left open, it will depend on a number of factors including the location and depth of the wound. There are some basic methods for cleaning bite puncture wounds available, read on for more information.