Neo Daniff

150-180 lbs
United States
Neopolitan Mastiff
Great Dane
Neapolitan Daniff

The Neo Daniff is a giant mix of the Neapolitan Mastiff and Great Dane, which are both giant dogs. They will weigh well over 150 pounds when full grown and can stand about 36 inches high. They are excellent guard dogs because of their size but they are also very lovable and friendly with everyone, including children and other pets. They enjoy spending time with their family and love to be cuddled but should be watched with small children because they are so large. The Neo Mastiff is easy to train and they are eager to please and very obedient. 

purpose Purpose
Guardian, Companion
history Date of Origin
ancestry Ancestry
Great Dane and Neapolitan Mastiff

Neo Daniff Health

Average Size
Male Neo Daniff size stats
Height: 30-36 inches Weight: 175-200 lbs
Female Neo Daniff size stats
Height: 26-32 inches Weight: 150-180 lbs
Major Concerns
  • Cardiomyopathy
  • Canine Hip Dysplasia (Chd)
  • Gastric Dilation Volvulus (GDV) or Bloat
Minor Concerns
  • Entropion
  • Ectropion
  • Glaucoma
  • Myotonia
  • Atopy
Occasional Diagnoses
  • Cataracts
  • Hypothyroidism
  • Deafness
  • Osteochondrodysplasia
Occasional Tests
  • Cardiac
  • Skin Evaluation
  • Ultrasound
  • Internal Imaging (x-ray, CT scan, MRI, etc.)
  • Blood And Urine Analysis
  • Electrocardiograph (ECG - measures rate and rhythm)
  • Eye and Ear Examination

Neo Daniff Breed History

The Great Dane came from Germany in 3000 B.C. as a watchdog and hunter. They are thought to be ancestors of the Irish Greyhound, Old English Mastiff, and the Wolfhound. There are drawings of dogs who looked like Great Danes discovered in the Temples of Babylon built in 2000 B.C. and written accounts of similar dogs in Chinese literature from 1121 B.C. so they may have been around longer. They were brought to many places around the world by Assyrians who traded their dogs to the Greeks and Romans. They were first referred to as Boar Hounds because they were bred to hunt wild boar but then were changed to English Dogges in the 1500s. The Germans later changed their name again to Kammerhunde, which means chamber dog. Once again, their name was changed in the 1700s to Grand Danois, which was later changed to Great Danish Dogs and ended up being called Great Danes. In 1887, this breed was acknowledged by the American Kennel Club and it is the 14th most popular breed of dog in America. The Neapolitan Mastiff has been around since ancient times and was used originally in Italy as a guard dog. These giant dogs descended from the British Mastiff and Roman War Dogs. With their droopy skin and giant features, they make an imposing guard for any household and were used to guard farms as well as estates. They almost disappeared after World War II but in 1946, they were reintroduced by a journalist named Piero Scanziana, who took a great interest in the breed. The American Kennel Club did not acknowledge the Neapolitan Mastiff until 2004 where it is the 99th most popular breed of dog.

Neo Daniff Breed Appearance

Your Neo Daniff can have brown or amber eyes and their nose may be blue, black, brown, or Isabella, depending on their coat color. Their coat is short and smooth, relatively short and thin in many colors such as brindle, sable, fawn, red, black, blue, brown, and white. They are rarely all one color but the colors are usually complimentary such as brown and fawn or black and cream. These are large huge that can get up to 36 inches tall and weigh close to 200 pounds. They have long, muscular legs, a large, rectangular body and big floppy ears on a big squared head. 

Eye Color Possibilities
brown Neo Daniff eyes
amber Neo Daniff eyes
Nose Color Possibilities
blue Neo Daniff nose
black Neo Daniff nose
brown Neo Daniff nose
isabella Neo Daniff nose
Coat Color Possibilities
brindle Neo Daniff coat
black Neo Daniff coat
brown Neo Daniff coat
red Neo Daniff coat
cream Neo Daniff coat
fawn Neo Daniff coat
white Neo Daniff coat
sable Neo Daniff coat
Coat Length
Short Medium Long
Coat Density
coat density
Sparse Normal Dense
Coat Texture
coat texture
Neo Daniff straight coat texture
Straight Wiry Wavy Curly Corded

Neo Daniff Breed Maintenance

The Neo Mastiff has a short coat and does not need too much brushing but does need to be brushed with a rubber curry mitt or slicker brush a couple of times a week. This will prevent excessive shedding and improve circulation to keep the skin and coat healthy. Your Neo Mastiff will need her ears cleaned a few times a month with cotton balls or a soft cloth. At this time, you should also check for irregularities like excessive earwax, dryness, or redness. To prevent peridontal issues and cavities, you have to brush your dog’s teeth with toothpaste made specially for dogs. In addition, you should trim your dog’s toenails about once a month or so. If there are folds in the skin or on the face, be sure to keep them clean and dry. Bacteria and yeast can build up, leading to skin trouble.

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Brushes for Neo Daniff
Slicker Brush
Slicker Brush
Nail Clipper
Nail Clipper
Brushing Frequency
fur daily fur weekly fur monthly
Neo Daniff requires weekly brushing
Daily Weekly Monthly

Neo Daniff Temperament

While the Neo Mastiff looks fierce and scary, they are just big lovable pets who like to cuddle. But, they are protective of their family, including the other pets in the house. They are smart and fast learners and obedient but can be stubborn at times. Training should be positive reinforcement rather than physical punishment because they may become aggressive. This breed is an excellent choice for any family and will fit in with everyone. They get along well with other dogs so taking a trip to the dog park is a good activity for them often to keep them socialized. 

Neo Daniff Activity Requirements

The Neo Mastiff does not do too well in a small apartment because they need room to move around. Having a fenced in yard is good so your dog can get out and run around for a time each day. Your Neo Mastiff would appreciate a couple of long walks every day and maybe a trip to the dog park to play with other dogs. Some other activities your Neo Mastiff may enjoy are hiking, swimming, agility and obedience training, playing fetch or flyball, and just running around in a secure area. It is important that your dog get enough exercise or they can become anxious or bored. 

Activity Level
low activity medium activity high activity
Low Medium High
Rec. Walk Mileage Per Week
12 miles
walk mileage
Minutes of Activity Per Day
60 minutes
activity minutes

Neo Daniff Food Consumption

Cups Per Day
4.5 cups
cup per day cost cup per day cost cup per day cost cup per day cost
Daily Cost
$3.20 - $4.00
food bowls daily cost
Monthly Cost
$96.00 - $120.00
food bag monthly cost

Neo Daniff Height & Weight

6 Months
Male Neo Daniff size stats at six months
Height: 29.5 inches Weight: 82.5 lbs
Female Neo Daniff size stats at six months
Height: 26.5 inches Weight: 62.5 lbs
12 Months
Male Neo Daniff size stats at 12 months
Height: 31.5 inches Weight: 125.0 lbs
Female Neo Daniff size stats at 12 months
Height: 27.5 inches Weight: 90.0 lbs
18 Months
Male Neo Daniff size stats at 18 months
Height: 33.0 inches Weight: 187.5 lbs
Female Neo Daniff size stats at 18 months
Height: 29.0 inches Weight: 165.0 lbs

Neo Daniff Owner Experiences

13 Weeks
4 People
House & Yard
Tammy loves playing with our small dogs, she’s good with cats. Hates to be alone And is learning fast but tends to chew things up when bored
9 months, 1 week ago
2 Years
3 People
House & Yard
going to the beach!
Car rides
She is smart but also stubborn. She is so goofy and has spurts of energy but is overall sleepy/lazy. She is friendly with other dogs and people but is super protective, therefore has a little bit of leash aggression that we’re working on. She is so affectionate and cuddly and is a huge lap dog
2 years, 6 months ago
21 Months
6 People
Car rides
Walks to the lake, car rides,
Exploring the woods
Love my neo/dane 3rd generation
5 years, 9 months ago
7 Weeks
3 People
House & Yard
Bath time
she's shy so far but very energetic when she get comfortable with me
4 years, 11 months ago
12 Weeks
4 People
House & Yard
Laying in the sun
He’s smart but not overly bright. Clumsy, and spends more time sleeping. Great with other dogs and people. Will make you aware of strangers but not aggressive. Overall passive demeanor and eager to please. House training relatively easily. Prey drive exists but is minimal. He’s on a farm with goats, pigs, and chickens. Correction to prey drive appropriateness is not overly difficult. Best of both breeds so far.
4 years, 10 months ago
7 Months
3 People
House & Yard
She is a ball on energy for about 5 - 10 mins then needs a nap. Loves meeting ppl and is super friendly outside of her yard. Is rather stubborn and has selective hearing. If it's bed time she doesn't hear you, but can hear the fridge open from the other side of the yard. Is very protective of her yard. I wouldn't want to mess with her if I saw her in someone else's yard. Loves to climb on the patio chairs and pretend she's a human. Doesn't like being alone and will cry. Doesn't have to been in your pocket but likes to be near. Most of the time she is very calm with short bursts of energy. Great family dog, perhaps with teenagers (due to their size and not realizing they are not a lap dog) The only down side is their life span is 8 - 10 years which can seem a little short with a lot of large dogs.
4 years ago
2 Years
2 People
House & Yard
I got Lionel as a rescue at 12months - he had been deemed unmanageable by 2 foster homes before coming to me as a foster. It took him a month to learn to loose lead walk and stop jumping,and a couple of weeks to sit and drop - he needed a consistent kind trainer but is very smart - I adopted him in the end - he is very lovable when he gets to know you, but is very intimidating to strangers at first - he is stubborn and doesn't react well to force at all - I would never recommend an aggressive training style with this type of dog (or any really) I think he has alot of the neo mastiff in him - he is very protective of his property and humans, and is wary and stubborn. I would not suggest this breed for people new to large dogs or those with children. He is very smart, excellent house members, and thrives on training games - this type of do would be great for adults, experienced dog owners, those who love to train and be interactive with their dog. He can be lazy - has spurts of energy then sleeps it of for 3hrs. They eat alot -be ready for a decent food bill. Good looking dog, I always get comments on how gorgeous he is! And he is!
3 years, 6 months ago
Book me a walkiee?
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