Enlarged Spleen in Cats
Written By hannah hollinger
Published: 08/29/2016Updated: 01/14/2022
Veterinary reviewed by Michele K.
Enlarged Spleen in Cats - Symptoms, Causes, Diagnosis, Treatment, Recovery, Management, Cost
What is Enlarged Spleen?
The spleen is an elongated organ that is on the left side of the stomach in cats. Though the organ isn't essential for living, an enlarged spleen may be a symptom of a more serious or chronic disease that will need veterinary care.
Splenomegaly, or an enlarged spleen, is a symptom of another condition or disease. The enlargement is due to inflammation, which occurs due to infiltration of abnormal cells as a result of the primary condition. The primary condition that is causing the enlargement is typically related to the function of the spleen, such as filtering blood or synthesizing antibodies in the cat's body. The cat's spleen may either enlarge uniformly over the entire organ or enlarge asymmetrically.
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From 558 quotes ranging from $200 - $2,000
Average Cost
$1,000
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Symptoms of Enlarged Spleen in Cats
Because the spleen is responsible for storing and filtering blood, removing old cells and foreign bodies from the bloodstream, and helping the immune system function properly, the cat may experience a variety of symptoms that warrant investigation in order to treat the primary cause of the enlargement. 
  • Lack of appetite
  • Weight loss
  • Enlarged lymph nodes
  • Swollen abdomen
  • Diarrhea
  • Vomiting
  • Abdominal pain/sensitivity
  • Lethargy
  • Weakness
  • Fainting
Causes of Enlarged Spleen in Cats
There are a variety of causes of splenomegaly in cats, which include: 
  • Abdominal injury due to trauma
  • Heart failure
  • Heartworms
  • Inflammatory bowel disease
  • Infectious disorders, such as feline infectious peritonitis
  • Cancer, such as multiple myeloma and feline leukemia virus
  • Bacterial infection
  • Autoimmune disorders, such as systemic lupus
  • Splenic torsion (rotation or twisting of the spleen)
  • Fungal infections, such as histoplasmosis
Diagnosis of Enlarged Spleen in Cats
The veterinarian will examine the cat, feeling for swollen lymph nodes and a swollen abdomen. In some cases, the enlarged spleen will be protruding through the abdominal skin and is noticeable with a visual examination. The veterinarian will need to know the cat's complete health history, all of the symptoms the cat is experiencing, and when symptoms first began.
A complete blood count, biochemical blood profile and a urinalysis will be taken. These tests will help the veterinarian determine the primary condition that is causing the spleen enlargement. The tests will also show how the other organs, such as the kidneys and liver, are being affected by the primary condition. The blood tests will typically also show signs of an enlarged spleen, which include a high white blood cell count, low hemoglobin levels (anemia) and abnormal cells that are causing the inflammation.
Diagnostic tests, such as an x-ray and ultrasound, will be performed. These tests will allow the veterinarian to view the spleen and the surrounding organs for any abnormalities. A fine needle aspiration may also be performed. During this test, the veterinarian will insert a thin needle into the spleen, drawing out a fluid sample for further analysis. In rare occasions, exploratory surgery may be necessary if a diagnosis isn't found with other tests.
Treatment of Enlarged Spleen in Cats
Treatment of the enlarged spleen will depend on treating the primary condition that is causing the inflammation.
Medication
Corticosteroids may be prescribed by the veterinarian in order to reduce the inflammation in the spleen and other organs. If the enlargement is due to a bacterial infection, antibiotics will be prescribed. Autoimmune primary causes will be treated with immunosuppressants, which work to suppress the reaction of the immune system. Cancer may be treated with chemotherapy, which will work to kill the cancer cells in the cat's body. Cats who are severely anemic may need to take iron supplements. Medications to treat fungal infections may also be prescribed.
Surgery
In cases of splenic torsion or trauma, the veterinarian may need to remove all or part of the cat's spleen (splenectomy). This will be done in the hospital under general anesthesia. During surgery, the veterinarian will make a small incision in the cat's abdomen. The entire spleen or affected portion of the spleen will be removed and the blood vessels attached to the spleen will be clamped and tied. The incision site will then be closed. Surgery may also be necessary to remove any tumors or masses that have formed due to cancer.
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Recovery of Enlarged Spleen in Cats
The cat will need to continue to take medication as prescribed by the veterinarian in order to prevent the primary condition from worsening and causing the spleen to enlarge once more. Follow-up appointments to monitor labs and medication will be necessary. If the cat had surgery, it's important to care for the incision site at home to prevent infection from occurring. Keeping the cat calm and stopping strenuous activities is essential in proper recovery.
Enlarged Spleen Average Cost
From 558 quotes ranging from $200 - $2,000
Average Cost
$1,000
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Enlarged Spleen Questions and Advice from Veterinary Professionals
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Shorthair tuxedo
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Thirteen Years
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1 found this helpful

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1 found this helpful

My pet has the following symptoms:
Enlarged Spleen
She had an enlarged spleen and it was drained and she was given fluids and antibiotics to administer at home. She had a sonogram and multiple cysts removed from her pancreas and sent to be biopsied.
Sept. 25, 2020
Answered by Dr. Michele K. DVM
1 Recommendations
Thank you for your question. I apologize for the delay, this venue is not set up for urgent emails. I hope that your pet is feeling better. If they are still having problems, It would be best to have your pet seen by a veterinarian, as they can examine them, see what might be going on, and get any testing or treatment taken care of that might be needed.
Oct. 23, 2020
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Domestic shortair cat
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dog-age-icon
2 yrs
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0 found this helpful

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0 found this helpful

My pet has the following symptoms:
None
Dr can’t determine if spleen is enlarged?
Sept. 24, 2020
Answered by Dr. Michele K. DVM
0 Recommendations
Thank you for your question. I apologize for the delay, this venue is not set up for urgent emails. I hope that your pet is okay. Without more information, and a clearer image, it is difficult for me to comment on your cats spleen If they are still having problems, It would be best to have your pet seen by a veterinarian, as they can examine them, see what might be going on, and get any testing or treatment that might be needed.
Oct. 24, 2020
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Bombay
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Elvis
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5 Months
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0 found this helpful

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0 found this helpful

My pet has the following symptoms:
Diarrhea
Pain
Lethargy
My kitten is 5 month old. Blood results say red blood cells are high at 10.06.The Neutrophils is low 22, lymphocytes are high 68 and Eosino is low,8. The SGOT/AST is high 59.30. and SGPT IS HIGH AT 102. The creatinine is low at .60. the vet gave him liver med but he isn't eating at all. should I force feed him? Also what's wrong with him
Aug. 27, 2018
Answered by Dr. Michele K. DVM
0 Recommendations
Without being able to assess Elvis or know more about his situation, I don't have any way to say what might be going on with him, other than his liver is irritated. This may have been caused by a toxin or something that he ate, or it may be a problem with his liver. If he isn't eating, you will need to force feed him, as cats can't go for more than 2-3 days without eating. Since I don't know very much about what is going on with him, it would be best to follow up with your veterinarian, as they know more about his condition and what might be helpful.
Aug. 27, 2018
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Ragdoll
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Pierre
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1 Year
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1 found this helpful

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1 found this helpful

My pet has the following symptoms:
Enlarged Spleen
Hi my cat had an episode of FLUTD. During his X-ray the vet saw what could potentially be an enlarged spleen. My cat was sedated for the X-ray, and had been on prasozin and buprenorphine previous to the X-rays. His blood work and urinalysis came back normal, but my vet is recommending an ultrasound, with another round of sedation. Could the enlarged spleen have been from the FLUTD or from the sedative administered prior to the X-ray?
July 17, 2018
1 Recommendations
The splenomegaly and the FLUTD isn’t related, however some anaesthetic drugs may affect spleen volume. Regards Dr Callum Turner DVM www.ncbi.nlm.nih.gov/pubmed/23106455 www.vin.com/apputil/content/defaultadv1.aspx?id=3859207
July 17, 2018
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Calico
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Alice
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5 Years
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0 found this helpful

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My pet has the following symptoms:
Irritable
Difficulty Urinating
Meowing A Lot
Constant Visits To Litter Box
My cat may have a UTI. We just toom another cat of ours in for a similar issue so money to take our Alice to a vet is non-existent right now. It appears that she can urinate a little bit. I've also noticed an upper part of her, completely to the side, chest area there is a soft swollen area. She doesn't like for it to be touched. My cat is still playing and mostly herself. Do you think my cat is going to die because of this? I'm so anxious and have been up all night worrying about my other baby now. Then other cat mentioned previously went in for similar symposium but the vet said that it was more than likely allergies. He gave my cat an antibiotic shot and a dexamethasone shot.He didn't receive a urinalysis because the doctor couldn't find any blockage and the cat appeared to have a normal bladder. I really need help. I know she needs to go to the vet regardless but what can I do until I get the money? Sorry for the plethora of inquiries I'm just desperate.
July 13, 2018
0 Recommendations
Whilst I understand that money can be tight, without examining Alice I cannot know specifically where the swelling is originating from (inside the abdomen or above the abdominal wall), the consistency among other things. Without examining her all I can advise is to keep her hydrated and eating, try to visit a charity clinic or other organisation to get her seen sooner. Regards Dr Callum Turner DVM
July 13, 2018
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moggy
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little girl
dog-age-icon
9 Years
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0 found this helpful

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0 found this helpful

My pet has the following symptoms:
Tired, Skinny
My cat went into the vets as she went abit skinny and tired. She was eating, drinking and going to the toilet fine. The vets done her bloods and said the bloods were fine but she does have some sort of infection so they put her on antibiotics they also said she had anemia too and they put her on steroids. They done a scan on her and said her spleen is englarged and said its possible she has a tumour. They said they can operate on the spleen as it would be high risk due to the anemia. But what I don't understand is why cant they needle it and test the fluid to check its deffo a tumour / cancer? I have to take her back in for a check up and re blood test. Any advice would be much appreciated thank you
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Shorthair
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Paris
dog-age-icon
10 Years
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0 found this helpful

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0 found this helpful

My pet has the following symptoms:
Enlarged Spleen
My 10 year old cat began havingg seizures. At a check up to reup her seizure meds it was discovered her spleen was very enlarged. Palpable the vet said. So much so that she stopped the visit and asked that I take my cat to a specialist as she was pretty sure cancer was to blame. Had other reasons to believe so. Called the specialist and the testing was extremely expensive and would also almost certainly cause a seizure. Also said if it is cancer, a splenectomy would not be an option due to kitty's small size. Didn't take her in. That was 5 months ago. Since then stopped meds and have not had another seizure. Kitty has good days more than bad as far as lethargy, appetite, digestion issues, etc. If cancer is to blame, what will the progression be? What should we expect?
Enlarged Spleen Average Cost
From 558 quotes ranging from $200 - $2,000
Average Cost
$1,000
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