Destruction of the Pituitary Gland Average Cost

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What is Destruction of the Pituitary Gland?

The pituitary gland is a small gland located at the base of the brain. Despite its size, the pituitary gland produces a number of different hormones that regulate other endocrine glands and control many functions throughout the body. Many important hormones are produced here, including thyroid stimulatory hormone (TSH), adrenocorticotrophic hormone (ACTH), growth hormone (GH), and antidiuretic hormone (vasopressin). Because it affects so much of the endocrine system, the pituitary gland is sometimes called the master gland. Tumors are the most common cause of pituitary destruction in older dogs, but an injury or infection can also destroy tissue. Most pituitary tumors are benign and slow growing, however, large tumors put pressure on the hypothalamus, the brain area next to the pituitary gland that regulates many important pituitary functions. A condition called panhypopituitarism results. This is a reduction the in normal levels of many pituitary hormones. Tumors can also affect other parts of the brain and even cause blindness. Panhypopituitarism may also develop in younger dogs due to a birth abnormality. Puppies with this problem, are small and stunted with very little hair, and usually have a shortened life span. This is most common in German Shepherds, but some other breeds also have a similar problem. Many secondary conditions can develop with panhypopituitarism, including hypothyroidism, Addison’s disease (hypoadrenocorticism), and diabetes insipidus. Pituitary tumors may also secrete hormones, most commonly ACTH which causes Cushing’s disease (hyperadrenocorticism). Surgical removal of a pituitary tumor is difficult and rarely attempted. In adult dogs, tumors sometimes shrink with radiation treatment, but in young dogs there are few treatment options.

The pituitary gland is a very important part of the endocrine system that regulates hormone production in many other glands. In dogs, the pituitary gland can fail to form properly, or it can be destroyed by a large tumor, injury, or infection. This leads to a condition called panhypopituitarism, a reduction in many different pituitary hormones.

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Symptoms of Destruction of the Pituitary Gland in Dogs

Take your dog to see a veterinarian if you notice any of the following symptoms.

In puppies

  • Slow growth after about 2 months of age
  • Gradual hair loss
  • Small sexual organs
  • Adult teeth do not come in
  • Stunted size

In adult dogs

  • Depression
  • Attitude change/less friendly toward people
  • Lack of coordination
  • Weakness
  • Weight loss
  • Excessive drinking
  • Increased urination
  • Blindness (in severe cases)

Types

There are two types of panhypopituitarism.

  • Juvenile-onset panhypopituitarism (pituitary dwarfism) – either the front portion of the pituitary gland fails to develop, or the puppy has a cyst or tumor from birth
  • Adult-onset panhypopituitarism – usually due to a tumor, more common in middle-aged or older dogs

Causes of Destruction of the Pituitary Gland in Dogs

  • Some breeds are more prone to juvenile-onset panhypopituitarism (German Shepherd, Spitz, Miniature Pinscher, Karelian Bear Dog)
  • Benign tumors causing adult-onset panhypopituitarism are found equally in all breeds
  • Some breeds have a higher rate of ACTH producing tumors that lead to Cushing’s disease (Boxer, Dachshund, Boston Terrier)
  • Infection or injury that destroys part of the pituitary gland can also cause adult-onset panhypopituitarism

Diagnosis of Destruction of the Pituitary Gland in Dogs

The veterinarian may suspect destruction of the pituitary gland based on your dog’s symptoms. Blood and urine test often show abnormalities related to hormone imbalances. The veterinarian may order tests to evaluate the functionality of other endocrine glands and determine the source of the problem. Many secondary conditions associated with the destruction of the pituitary gland can also be caused by an adrenal or thyroid tumor, so this is an important step. An ACTH stimulation test or a dexamethasone suppression test (DST) is often ordered to diagnose Cushing’s disease and determine if it is caused by the pituitary gland or the adrenal glands.

Pituitary tumors causing panhypopituitarism are usually large enough to be diagnosed with magnetic imaging. X-rays and ultrasound will be taken and the vet may order a CT scan or MRI for clearer imaging. Other x-rays may be needed to check for metastasis or to evaluate the potential of tumors in other glands. The veterinarian will need to know your dog’s age and breed. Past medications can also be relevant since long term steroid use is often related to hormone imbalance.

Treatment of Destruction of the Pituitary Gland in Dogs

Puppies with pituitary dwarfism are given various hormone treatments. Thyroid replacement hormone and growth hormone can help to make up for the lack of normal stimulant hormones from the pituitary gland. Canine growth hormone has not been manufactured, so dogs are usually given human or pig GH. This is effective in some dogs, while others have adverse reactions. Progesterone can help some puppies grow and regain normal hair growth, but there are significant side effects with this treatment.

Surgical removal of pituitary tumors is difficult and risky, so it is rarely recommended. Radiation treatment can help to shrink some tumors in dogs with adult-onset hypopituitarism. Radiation will be given in several doses over a 2-5 week period. Dogs often have minor skin reactions at the time. Long-term serious side effects are possible, so discuss the necessity and risk of this treatment with your veterinarian. 

Hormone treatment and other medications may be necessary for secondary conditions. Dogs with Cushing’s disease, Addison’s disease or hypothyroidism will often need lifelong medication. Dogs in an Addisonian crisis may need emergency treatment with intravenous fluids and electrolytes. 

Recovery of Destruction of the Pituitary Gland in Dogs

Puppies with pituitary dwarfism are given various hormone treatments. Thyroid replacement hormone and growth hormone can help to make up for the lack of normal stimulant hormones from the pituitary gland. Canine growth hormone has not been manufactured, so dogs are usually given human or pig GH. This is effective in some dogs, while others have adverse reactions. Progesterone can help some puppies grow and regain normal hair growth, but there are significant side effects with this treatment.

Surgical removal of pituitary tumors is difficult and risky, so it is rarely recommended. Radiation treatment can help to shrink some tumors in dogs with adult-onset hypopituitarism. Radiation will be given in several doses over a 2-5 week period. Dogs often have minor skin reactions at the time. Long-term serious side effects are possible, so discuss the necessity and risk of this treatment with your veterinarian. 

Hormone treatment and other medications may be necessary for secondary conditions. Dogs with Cushing’s disease, Addison’s disease or hypothyroidism will often need lifelong medication. Dogs in an Addisonian crisis may need emergency treatment with intravenous fluids and electrolytes.

Destruction of the Pituitary Gland Questions and Advice from Veterinary Professionals

Wolfie
Alaskan Malamute
8 Years
Serious condition
1 found helpful
Serious condition

Has Symptoms

Depressed
Pain
Weakness
Thin Skin
Fatigue
Weight Loss
Hair Loss

Medication Used

Vetoryl
Dasuquin Chews
Thyroxin
Metacam

I have an 8 year old Alaskan Malamute. He has been diagnosed with Cushings. He's been both thyroid and Cushings meds for about 2 months now. He has all the classic symptoms but he cannot gain weight. Wolfie used to weigh 88 lbs and now he's down to 58 and just withering away. His appetite is very good and we feed him 4-6 times a day just to help him try to gain weight. His health has definitely deteriorated in the last 2 weeks. He's walking around aimlessly and circles for hours. Is there a reason he won't gain weight even though he is eating so much a day? I feel so bad for him and don't know what else to do to make him gain weight. Currently we give him his meds, metcam, digestive enzymes, grain free, organic wet and dry food.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
2930 Recommendations
Sometimes Vetoryl may cause a reduction in appetite, but if Wolfie’s appetite is good and is still losing weight there may be another cause; you have covered different bases with digestive enzymes and a varied diet. I would have your Veterinarian check him again to ensure that the dosages of the medications are sufficient to to help maintain his weight on this diet. Regards Dr Callum Turner DVM

Thank you very much for your response. Wolfie is going to see his vet later on today.

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Cookie
Chiweenie
Almost 8
Mild condition
0 found helpful
Mild condition

Has Symptoms

She has every symptom of Cushings!

Medication Used

N/A so far

Hello!
I just recently found out that my dog was diagnosed with cushings disease, pituitary tumor, the DR told me not to put her on medicine just yet! (All of her results were just on the border of ("cushings")
What would be the the next best step! How to alleviate symptoms of excessive panting
Thanks!

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
2930 Recommendations

Each case of Cushing’s Disease is different (as with other conditions); if your Veterinarian is delaying treatment, ask them for their rationale as they have have noticed something else or may be waiting on more information. The cause of the panting can be due to many different parts of Cushing's Disease including liver enlargement, reduction in respiratory volume (to name two). You should discuss your concerns with your Veterinarian as Cookie is under their duty of care. Regards Dr Callum Turner DVM

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Oreo
Maltese
16 Years
Serious condition
0 found helpful
Serious condition

Has Symptoms

Poor balance
Loss of Balance
Urinating

Medication Used

For congestive heart failure in vet hospital on iv

My 16 year old Maltese may have a tumor in pituitary gland. Is surgery or radiation recommended. He has all the symptoms and I asked he be tested for Cushing but was told it ways not. He recently got hospitalized for HGE.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
2930 Recommendations

Generally to confirm a diagnosis of pituitary gland tumour, imaging studies like CT or MRI are used; however, clinical signs and blood tests may be suggestive. Due to the location of the pituitary gland, surgery is usually not possible and medical management (or in some cases removal of the adrenal glands), discussion with an Endocrinologist or an Oncologist may help. Regards Dr Callum Turner DVM

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