Vaccine Allergies Average Cost

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What are Vaccine Allergies?

Allergic reactions to vaccines are abnormal reactions to the vaccine itself, or they can be the result of the body overreacting to a vaccination. Dogs commonly experience some side effects that result from receiving a necessary vaccination. While these symptoms are typically not a cause for concern and will resolve within one or two days, if the symptoms persist or they cause a lot of discomfort, it will be necessary to contact your veterinarian. You may see redness at the injection site and your pet could be lethargic for a day or two. While these are not serious effects, you may want to call your veterinarian if symptoms linger or worsen.

Vaccine allergies can occur in dogs after they receive standard vaccinations. Symptoms can vary, and complications can occur if the side effects don’t resolve on their own.

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Symptoms of Vaccine Allergies in Dogs

An allergic reaction to a vaccine could happen right away, or it could take as long as 48 hours to manifest. Also, allergic reactions are more common with booster shots rather than initial vaccines because the immune system will already have a memory of the disease that the vaccine works against, and could mistakenly react to the vaccine as if it were harmful to the body. 

Symptoms of vaccine allergies include:

  • Diarrhea
  • Vomiting
  • Lethargy
  • Swelling or redness at the vaccine site
  • Puffiness around the ears, muzzle, and/or eyes
  • Bumps or hives all over the body

Although very rare, more severe allergic reactions can occur. These include anaphylactic reactions, collapse, and death. 


There are several different types of allergic reactions that can occur after a vaccine is administered:

  • Anaphylaxis - Although rare, this allergic reaction is life threatening and can result in respiratory failure, cardiac failure, shock, and death if left untreated. The reaction could happen within minutes or hours of injection. Common signs include sudden vomiting, diarrhea, seizures, coma, shock, cyanosis, a weak but rapid pulse, and facial swelling.  
  • Eye and neurologic disease - Inflammation of the brain or eyes may occur.
  •  Reactions at the injection site - Irritation, swelling, pain, and redness can develop at the site of injection, typically anywhere from 30 minutes to a week after the vaccine is given. Abscesses can also form at the site of injection.
  •  Respiratory symptoms - A mild cough, sneezing, or discharge from the nose can occur as an allergic reaction to intranasal vaccinations.
  • Decreased activity and appetite, as well as depression and mild fever - These symptoms can occur for about one or two days after receiving a vaccine.

Causes of Vaccine Allergies in Dogs

  • Allergic reactions will vary depending upon the type of vaccination that is administered 
  • Occurrence of an allergic reaction will depend upon an individual dog’s immune system and how it reacts to the components within a vaccine
  • The breed and age of your dog will also play a role in whether or not he has an allergic reaction
  • Researchers have found that the more vaccines that are administered at the same time, the higher the risk for an allergic reaction, particularly for small canines

Diagnosis of Vaccine Allergies in Dogs

If an allergic reaction to a vaccine occurs immediately or a few minutes following administration at your veterinarian’s office, they will be able to provide prompt relief and treatment as soon as symptoms become apparent.

If your dog receives a vaccination and begins exhibiting any of the symptoms associated with an allergic reaction after going home, contact your veterinarian right away, especially if the symptoms are severe.

Usually, your veterinarian will not have to perform any formal tests in order to determine if an allergic reaction to a vaccine is occurring. Instead, clinical signs and examination findings, along with the records of a recent vaccination, will likely be enough information to diagnose the condition in a timely fashion. However, your veterinarian may want to do a complete blood count, urinalysis, and fecal analysis in order to determine if any organ systems in the body have been adversely affected. These diagnostic tools can also determine if your pet has an underlying illness that may have caused a vaccine reaction.

Treatment of Vaccine Allergies in Dogs

Treatment for vaccine allergies in dogs will depend upon the level of allergic reaction and the type of vaccine that was administered. Your veterinarian will determine what the appropriate treatment will be after thoroughly examining your dog. 

If your pet is experiencing a mild reaction to the vaccine such as redness around the injection site, the veterinarian may administer an antihistamine or an injection of  cortisone to reduce the swelling. If there is vomiting, the veterinary team may monitor your dog for an additional time before allowing you to take your dog home.

In the case of an anaphylactic reaction, your dog may have to be admitted to the clinic for intravenous therapy or additional medical intervention such as oxygen support or epinephrine. Once the veterinarian feels he is out of danger, your pet will be allowed to go home. The veterinarian may recommend you monitor your pet at home for the next several hours to few days.

Recovery of Vaccine Allergies in Dogs

The sooner you can get your dog to the clinic after the development of  signs of an allergic reaction to a vaccination, the higher the odds that he will recover, especially if the signs are severe. Overall, the prognosis for vaccine allergies in dogs is good. Dogs very rarely suffer from long-term side effects after a receiving vaccine, and it is also very rare that a dog will die as a result of receiving a vaccine. If your pet has an allergic reaction to a vaccine, this will be noted in his file at the clinic so that necessary precautions can be taken when the next vaccine is due.

Vaccine Allergies Questions and Advice from Veterinary Professionals

Chihuahua/ maltese
18 Months
Fair condition
0 found helpful
Fair condition

Has Symptoms

Shaking, trembling.

My 7lb Malchi has an allergic reaction to his vaccinations that was diagnosed by his vet. I think it was back in feb we found this out. Today he is having the same reaction but he hasn’t had any shots. I was wondering how long does a vaccine usually stay in a dogs body before it’s gone? Thanks.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
2950 Recommendations
Vaccines don’t spend a long time in the body because they cause an immune system reaction against themselves; it is possible that Bandit has come into contact with an infection and the body is having a similar reaction. You should check in with your Veterinarian to be on the safe side and to give treatment if required. Regards Dr Callum Turner DVM

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3 Years
Serious condition
0 found helpful
Serious condition

Has Symptoms

Pale Mucous Membranes

Medication Used

Vitamin K

My 3 year old chihuahua was vaccinated with the DHPP and rabies vaccination last year within a 3 week period and roughly about a couple of days after his rabies vaccination, he presented with acute immune-mediated thrombocytopenia (he began bleeding through his gums and was not clotting). He had to undergo a blood transfusion which ultimately saved his life. It is unknown as to whether this was caused by the DHPP vaccine or the rabies vaccine or if was caused by the vaccinations at all but now he is due for his vaccinations again and I am terrified. What are the chances that this was caused by the DHPP vaccination? and if it was, how can I protect him against those diseases without the vaccination? This was his first vaccination ever and does not have a history of thrombocytopenia. He is also the oldest in a litter of 3 and his other 2 brothers did not react to the vaccinations.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
2950 Recommendations
There is some debate about whether vaccination (especially with rabies vaccination) and whether or not there is a link to immune mediated thrombocytopenia; some say there is a link whilst studies haven’t found a statistically significant link. You should discuss this with your Veterinarian and if you choose to vaccinate Celtic again, I would recommend having him monitored regularly for the three to five days after vaccination. There is a link to an article from a reputable website about this subject. Regards Dr Callum Turner DVM “No statistically significant association between recent vaccination and a diagnosis of presumptive primary immune-mediated thrombocytopenia (IMT) was found in a recent retrospective study that examined 48 dogs presumed to have IMT and 96 control dogs.”

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Great Dane
4 Months
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

wet nose
Rapid breathing

Medication Used

second & Third set of immunizations

I have a 4 month old Great Dane Puppy who developed severe shortness of breath (rapid breathing and panting) two to three days after his second set of vaccines. We took him to the vet and he was diagnosed with fluid on the lungs. he was given a steroid shot and antibiotics for 10 days. He recovered. He just had another set of shots on Friday and by Sunday he is panting again and rapid breathing though his energy is still high. He also has diarrhea now. Could this be an allergic reaction to his immunizations?

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
2950 Recommendations
In some dogs, severe reactions like pulmonary edema may occur after vaccination; however, this should now be noted by your Veterinarian so that they can take mitigating measures to help lessen the severity of this reaction during the next vaccination. If the level of the reaction isn’t life threatening, you should continue to vaccinate Rocket to ensure that he say protected against life threatening and expensive diseases. Regards Dr Callum Turner DVM

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3 Months
Mild condition
0 found helpful
Mild condition

Good day!

My dog got his first anti rabbies yesterday. Today, we notice that his face swollen especially in the eyes. He got redness in the body too. Is it possible that he is allergic? By the way, he got Biocan R. Thank you so much.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
2950 Recommendations
It is not uncommon for dogs to have an adverse reaction to a rabies vaccination, generally the reaction is less severe than the disease itself; if you are noticing swelling you should return to your Veterinarian so that they can examine and note the reaction as well as offering symptomatic care. If the swelling is causing issues with breathing visit an Emergency Veterinarian. Regards Dr Callum Turner DVM

Her lungs ARE filled with fluid

My puppy got her third set of shots today at 11 weeks old. She is a standard goldendoodle and weighs around 15 pounds. After she shot she immediately started showing signs of distress. Unable to breathe and coughing. Within 5 minutes of the shot she was hooked up to an IV and was give oxygen so we reacted as quick as possible. She has now been transferred over to Mississippi State Vet school where they have access to more than my local vet. She has lived 10 hours and they say if they are not going to make it, it will almost be within the first hour. Her lungs aren't filled with fluid at this point and that is the main concern.

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Yorkshire Terrier
6 Years
Mild condition
0 found helpful
Mild condition

Has Symptoms

Vomit, itching and head shaking, cry

Hello, my5kg dog was vaccineted yesterday with obivac L4 and nobivac DHP. He had some stomach symptoms later on, them he vomitted several times, and had a lot of itching that made him crazy. He shaked his head a lot, and didnt stop yelping the whole night.the vet this morning said he had no fever and heart beat ok so sent memas back home. He is still yelping. What can i do?

Dr. Michele King, DVM
Dr. Michele King, DVM
1376 Recommendations
Thank you for your email. I'm a little surprised that your veterinarian didn't give Lucky an anti-histamine of some kind to help with what seems to be a reaction to his vaccination. Since you just saw them, you should be able to either call or take him back over and ask for treatment for his discomfort. There are injections of an antihistamine as well as oral doses that your veterinarian can prescribe if that is appropriate. I hope that he feels better soon!

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