What is Antifungal Therapy?

Fungal infections can result from an overgrowth of your dog’s natural body flora, or due to infection from parasitic fungi. Your dog's body surface and gut contain naturally occurring Candida or yeasts that can overgrow and create a yeast infection when your dog's natural chemical balance is affected. This usually manifests on the skin as itchiness, redness, inflammation, and sores, but can also affect internal organs. Also, parasitic fungal infections such as ringworm are common in dogs. Dogs frequently have their ears affected by fungal infections, especially dogs with floppy ears and excessive hair in the ears. When overgrowth or infection by fungal organisms occurs in your dog, your veterinarian can prescribe antifungal medication, both topically and orally, to relieve symptoms and stop yeast organisms. In addition, changes to diet may help limit fungal infections from proliferating in the future by ensuring natural flora stays balanced and does not grow out of control. 

Antifungal Therapy Procedure in Dogs

Antifungal therapies may be given orally or topically. Often a combination of both is prescribed. Topical treatments can consist of baths or rinses and/or antifungal creams applied to the affected areas. You veterinarian may take a skin scraping of the affected area and send for laboratory analysis to determine what type of yeast organism is present, which will help determine the most effective course of treatment.

During treatment, your dog should be monitored for harmful side effects and if treatment is required, long-term blood analysis and urinalysis may be recommended to ensure your dog's liver is not being adversely affected.

Oral, systemic medications that provide antifungal therapy include:

  • Ketoconazole
  • Terbinafine
  • Itraconazole
  • Fluconazole
  • Voriconazole 
  • Posaconazole

Various oral medications are more or less effective for different types of infections and vary in costs and side effects. Your veterinarian can advise you on the most appropriate oral antifungal therapy for your dog.

Antifungal creams are used topically on your dog's skin where fungal infections are present. Gloves should be worn to prevent spread, if contagious fungal infections are suspected. Antifungal creams soothe irritation and kill fungal infection. Common antifungal creams contain the following active substances: 

  • Chlotrimazole
  • Econazole
  • Itraconazole
  • Ketoconazole
  • Miconazole

Baths with medicated shampoos to counteract oily skin may contain sulfide, or benzoyl peroxide, and may be part of the strategy to combat yeast dermatitis in your dog. This can be followed up with an anti-fungal shampoo containing chlorhexidine, miconazole or ketoconazole. These antifungal shampoos must remain on the skin for at least 10 minutes in order to be effective and will require repeating every few days for several weeks.

If a bacterial skin infection is also present with the yeast infection, antibiotics may also be prescribed by your veterinarian.

Efficacy of Antifungal Therapy in Dogs

Fungal infections are not uncommon in dogs and are usually successfully treated. If infections are left until severe skin problems and secondary infections occur, antifungal therapy can prove more challenging, and additional intervention may be required, such as antibiotics. If immune system compromise or allergies is a contributing factor, and is not addressed, recurrence of fungal infections may occur.

Antifungal Therapy Recovery in Dogs

Your dog may experience side effects from antifungal medications including nausea, diarrhea, and loss of appetite during treatment. Supporting your dog by ensuring they stay hydrated and have appropriate food that will not further aggravate gastrointestinal symptoms is required. You will need to administer medication for several days or weeks to address yeast infection. Oral medication should be given as directed and may be given with food if appropriate to address gastric symptoms. Antifungal creams should be applied as directed to skin and gloves should be worn to prevent contamination if ringworm or other contagious fungal infection is present. If contagious conditions are present, take steps to protect other pets in the home. Care may need to be taken to ensure your dog does not lick antifungal cream off after application and an E-collar or bandage may be required.

Ear infections from yeasts require intensive cleaning and aggressive treatment with antifungal creams, and the more care provided by pet owners to remove debris and hair and to ensure medication is received, the more effective antifungal therapy will be in resolving the condition. Cleaning to remove dead candida and fungus organisms after treatment is important to prevent reinfection.

Cost of Antifungal Therapy in Dogs

The cost of antifungal therapy depends on the type of therapy required and consultation fees from your veterinarian. Systemic oral medications range from $0.40 to $11.00 per day and may be required for several days or weeks and on an ongoing basis where chronic recurrence of infection is present. Topical preparations and baths range from $5 to $50 depending on the product and may require multiple treatments to address candida infection.

Dog Antifungal Therapy Considerations

Besides gastrointestinal symptoms, toxicity and liver compromise can occur with antifungal medication, especially if administered long term. Many medications are not appropriate for pregnant or lactating dogs and your veterinarian should be informed if this is a factor.

Antifungal Therapy Prevention in Dogs

Natural antifungal medications and diet can be administered to your dog on an ongoing basis to prevent fungal infections from taking hold in your dog. Diets that support the immune system may prevent imbalance and disorder that allow naturally occurring flora to proliferate. In addition, making sure that your dog is not exposed to damp, dirty conditions by changing bedding and bathing them when required will reduce the incidence of yeast infections. If your dog has floppy ears or hair in their ears, regular cleaning, removal of hair, and natural antifungal preparations can be used to help prevent infections in the ears. Ringworm can be avoided by limiting your dog's exposure to other pets who exhibit infection or when parasitic status is unknown.

Antifungal Therapy Questions and Advice from Veterinary Professionals

Staffordshire Bull Terrier
5 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Irritated skin
strong smell

I have a four year old staffy that i have not had long.
He has had an ongoing skin condition it seems for 2 years.
His skin on his belly and paws are quite pink but since putting him on food without sugar etc his hair is growing back, we also do not give him treats unless we know they are natural. However he continues to have a strong smell. We have a vet recommended shampoo and rinse him in a mix of white vinegar and water but he smells again the day after. Are there any antifungal tablets you could recommend maybe?

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8 Years
Serious condition
1 found helpful
Serious condition

My collie seemed to get a very bad skin problem,terrible odor ,crusty skin constant itching after being on apoquel for seasonal allergies.terrible quality of life,losing fur and constantly scratching himself raw!we have him on antifungal medication and antibiotic for a week now but haven't noticed any difference yet.

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16 Years
Moderate condition
1 found helpful
Moderate condition

Has Symptoms

Difficulty Walking

My dachshund has a yeast infection in both ears from his sister's incessant licking. He was put on TriZultra w/Keto Flush and his arthritic-like disoriented walking and inability to fully shake his head resolved within 3 days. The TriZultra was continued for a total of one week, then the followup visit showed the infection was not entirely gone, so we were instructed to simply 'maintain as needed'. Ozzy and his sister Zoey were and are now kept separate most but not all of the time, and she succeeded in licking his ear several times (no returning symptoms yet), including after stopping the ear drug, which is now being resumed (not sure for how long it will be); tabasco sauce works but hasn't been entirely reliable, and mom still insists on letting them be together (and fails to consistently supervise when they are) too often.

I don't want to risk overuse of a synthetic antifungal, especially given Ozzy's age, and I know there are safer natural antifungals that do work, but mom only trusts the input of licensed practitioners and I don't know if there are any holistic ones in the area. She actually told the vet at the second visit that she was considering cleaning his ears with diluted apple cider vinegar as is recommended by many holistic vets, but his response was that it's fine only for dogs in drier climates than the Pacific Northwest. I'm not sure if he knows anything about witch hazel but that one sounds of less potential for irritation, though his ears are not red or currently bothering him. I also have heard that it evaporates fast and thus shouldn't leave much opportunity for reinfection. Also heard that green tea is good, but probably doesn't evaporate as fast. What would you recommend, how often and for how many days at a time, especially if mom keeps giving Zoey the chance to lick Ozzy's ears practically every day but doesn't want to pay to have another ear infection test done?

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations

It is good for dogs to be together but then comes the problem when excessive licking occurs; I would recommend covering Ozzy’s ears like the product on the first link below. There are natural treatments available which are discussed in the book linked to in the second link below which uses witch hazel or other products for management of ear infections; I tried to find some published scientific literature regarding the use of witch hazel and it’s efficacy but could find anything showing any results. Regards Dr Callum Turner DVM

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7 Years
Moderate condition
1 found helpful
Moderate condition

Has Symptoms


Medication Used


Bentley has been diagnosed with blastomycosis. 6 wks ago it was presumably sporotrichosis. He has been on ketoconazole for 6 weeks and just started itraconazole today. Do you think the side effects will be worse now? He finally got his appetite back after the first 3 wks on the ketoconazole. He also had to have his left eye removed on Thursday. Pressure was 51 from fungal infection...hoping he won’t lose his appetite again. Although he just got it back yesterday after the eye surgery..

Dr. Michele King, DVM
Dr. Michele King, DVM
Dr. Michele King DVM
1611 Recommendations
I'm sorry that poor Bentley is having all of this happen to him! Itraconazole doesn't tend to be as hard on the stomach as Ketoconazole, and since he is already adjusting to the medication, he shouldn't have a dramatic decrease in appetite. If he does, you can talk with your veterinarian, as they may be able to adjust his dosage while he gets used to the medication. I hope that everything goes well for him.

Thanks so much!! Poor baby has been through a lot but we WILL conquer this!!!

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