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- Increased thirst and urination
- Difficulty urinating or blood in the urine
- Lethargy
- Weakness
- Reduced appetite or refusal to eat
- Vomiting
- Constipation
- Unexplained weight loss
- Gastrointestinal function problems
- Depression
- Confusion
- High blood pressure (hypertension)
- Swollen lymph nodes
- Presence of mass on neck near voice box
- Bladder stones
- Seizures
- Muscle twitching
- Stupor and coma in extreme instances
- Poor diet or improper nutrition, including unbalanced all-meat diets
- Sudden or long-term renal failure
- Cancer or tumors, including carcinomas in the lungs, mammary glands, thyroid, pancreas, sinuses, testes or vagina
- Overactive parathyroid gland (hyperparathyroidism)
- Underactive adrenal glands (hypoadrenocorticism)
- Bone diseases, including fungal infections or cancer
- Poisoning from rat or mouse poisons
- Ingestion of calcium or vitamin supplements
- Aluminum toxicity
- Idiopathic hypercalcemia where a conclusive cause has not been determined
- Electrolyte panel to determine calcium, phosphorus, and salt levels
- Urine culture to rule out infections of the urinary tract
- Feline leukemia (FELV)
- Feline immunodeficiency virus (FIV)
- Parathyroid hormone (PTH) or PTH-rP concentrations
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