Etodolac for Dogs

Written By Kim Rain
Published: 12/16/2020Updated: 06/23/2021
Etodolac for Dogs | Wag!

Etodolac is a non-steroidal anti-inflammatory drug (NSAID) used for treating inflammation, fever and pain in dogs over 12 months old and over 11 pounds. It is often prescribed to help the discomfort and joint stiffness of arthritis, and can also be used for post-operative pain control.


Generally sold by the tablet, the cost of etodolac can vary depending on the dosage strength. Ranging from 200 mg to 500 mg, each tablet is priced between $1 to $2. Bottles of 100 tablets can cost upwards of $60 to $100.


Etodolac is available as tablets in 200 mg, 300 mg, 400 mg, or 500 mg dosages. General dosing guidelines are as follows:

The dose may be adjusted to find the most effective amount that is tolerated by your dog. If given for long-term pain management, your veterinarian will seek to find the lowest effective dose possible.

Dosage instructions

Administer etodolac for dogs once daily by mouth as prescribed by your veterinarian. This medication should be given with food to reduce stomach upset. Do not give larger doses or administer for a longer period of time than your veterinarian recommended.
Your veterinarian may also monitor your dog for side effects, especially when using etodolac for long periods of time. 


In  one study, the effects of etodolac were compared against three other medications that manage pain and inflammation. Etodolac was shown to have the fastest onset of action in the relief of acute synovitis or a painful swelling in the joint.

Etodolac for dogs can also improve the function of rear limbs of dogs suffering from chronic osteoarthritis due to its ability to reduce the inflammation and pain associated with the condition.

Side effects of Etodolac

There are several side effects associated with etodolac, which can range from mild to serious. Etodolac can cause damage to the stomach and intestines, especially during long-term use. If you notice any of the following mild symptoms, keep administering etodolac and speak with your veterinarian.

  • Diarrhea
  • Constipation
  • Dizziness
  • Skin itch

If you notice any of these more serious symptoms, stop giving etodolac and call your veterinarian immediately:

  • Black, bloody, or tarry stools
  • Vomiting or coughing up blood or material that looks like coffee grounds
  • Lethargy
  • Loss of appetite
  • Sudden weight gain
  • Decrease or absence of urination
  • Darker than usual urine
  • Nausea
  • Stomach pain
  • Blistering or peeling skin
  • Red skin rash
  • Yellowing of eyes
  • Abnormal bleeding
  • Signs of keratoconjunctivitis sicca, or dry eye, which include squinting and eye discharge
  • Incoordination
  • Fever
  • Chills
  • Seizure


Etodolac is only FDA approved for dogs over 12 months of age and weighing over 11 pounds. Dogs under 1 year of age or under 11 pounds should not use etodolac as there have not been sufficient studies to determine its safety for these dogs. Etodolac should not be used in breeding, pregnant, or nursing dogs.

Dogs allergic to etodolac, aspirin, or any other NSAIDs should not use this medication. Use etodolac with caution in dogs with stomach ulcers, gastrointestinal disease, kidney disease, bleeding or blood clotting disorders, heart disease, or heart failure.

The use of etodolac can cause serious problems in the stomach and intestines, including bleeding.

Drug interactions

Etodolac (EtoGesic, Lodine) may interact with the following medications:

  • ACE inhibitors
  • Diuretic (furosemide)
  • NSAID medications (aspirin)
  • Corticosteroids
  • Antihistamines
  • Anti-inflammatory medications
  • Pain medications

Always tell your veterinarian of any medications, vitamins, supplements, or herbal therapies your dog may be taking before starting etodolac.

Allergic reactions and sensitivity

Some dogs may be sensitive or allergic to etodolac. If you see signs of an allergic reaction to this medication, including difficulty breathing, swelling in the face, tongue, or throat, or hives, contact your veterinarian immediately. Other  symptoms can include intense scratching, head shaking, watery eyes, weakness, and collapse.

Frequently asked questions

Do I need a prescription for etodolac?

Etodolac does require a prescription from your veterinarian.

What do I do if I miss giving my dog a dose?

If you miss a dose of etodolac for dogs, give the dose as soon as you remember. If it is near the time for the next dose, then skip the missed dose and administer the regularly scheduled dose on time. Never give your dog two doses of this medication at one time.

Will my veterinarian need to monitor my dog?

Due to the serious side effects that can occur with etodolac use, your veterinarian may monitor your dog periodically for any reactions and to adjust the dose. Testing may include blood, urine, or kidney tests. Etodolac can alter the results of thyroid testing.

How is etodolac stored?

Store etodolac between 59°F and 86°F (15°C and 30°C) away from light, moisture, and heat. 

What do I do in case of an emergency?

If you suspect an allergic reaction or overdose of etodolac in your dog, seek attention from your veterinarian or emergency veterinary clinic immediately. Toxic amounts of etodolac can cause kidney failure and severe gastric bleeding.  Signs of an overdose of etodolac can include vomiting, the presence of blood in vomit, severe weight loss, bloody or irregular stools, lethargy, abdominal pain, and seizures.

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