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Adverse Reaction to Rabies Vaccine in Cats
Written By hannah hollinger
Published: 04/19/2017Updated: 06/01/2021
Veterinary reviewed by Michele K.
What is Adverse Reaction to Rabies Vaccine?
Cats need to have a rabies vaccine to protect them, especially if they are outdoors and have the potential of having personal contact with other animals that could be affected with the rabies virus. In the United States, the number of reported rabies cases in cats exceeds the number of cases in dogs. Rabies is a major health concern since it is able to be passed between species and to humans. 
In most states, it is mandatory for your cat to have the rabies vaccine. Some counties allow for a three year vaccine to be given while others require a yearly vaccine. Be sure to research your county’s laws regarding vaccinations for your cat. If you are unsure about what vaccinations are required by law for your cat, contact your veterinarian for assistance.
Generally, if your cat has a reaction to the rabies vaccine it will be minor. There have been cases, though, where the reaction is life threatening. When your veterinarian administers the rabies vaccination to your cat, be sure to watch your cat closely for several hours for any signs of having an adverse or allergic reaction.
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Symptoms of Adverse Reaction to Rabies Vaccine in Cats
Your cat may exhibit mild signs of an adverse or allergic reaction to the rabies vaccine. Those signs generally lessen over a few days and then resolve. Your cat may also develop serious signs from their vaccine that will need veterinary intervention and treatment. If you notice any of these signs, mild or severe, contact your veterinarian for an immediate appointment. 
Signs of a mild reaction or allergy to the rabies vaccine in cats include:
  • Vomiting
  • Swelling at the injection site
  • Pain at or near the injection site
  • Fever (low grade)
  • Diarrhea
  • Appetite loss
  • Lethargy
  • Itching 
  • Sneezing 
Signs of a serious reaction to the rabies vaccine in cats include: 
Vaccine Associated Fibrosarcoma
This is the development of a cancerous tumor at the injection site. The tumor can develop from a few weeks to a year after the vaccination has been given.
Organ Damage
The protein that is in the rabies vaccine can potentially damage your cat’s kidneys, liver and/or central nervous system. Organ damage can occur up to 45 days after the vaccination has been given. 
Anaphylactic Shock
Immediate veterinary care is required if your cat experiences anaphylactic shock, death can occur quickly without prompt treatment. While uncommon, signs of anaphylactic shock include facial swelling, difficulty breathing, coma, seizures, or death.  
Causes of Adverse Reaction to Rabies Vaccine in Cats
An adverse reaction can occur when your cat is exposed to some form of allergen, in this case, something within the rabies vaccine, and its immune system begins attacking itself. 
Diagnosis of Adverse Reaction to Rabies Vaccine in Cats
Your veterinarian will begin their assessment of your cat by asking about your cat’s medical history including any recent vaccinations, diet changes or environmental changes. They will then conduct a physical examination. A urinalysis, fecal exam, complete blood count and biochemistry panel may be completed to rule out other possible causes of the adverse reaction.
Treatment of Adverse Reaction to Rabies Vaccine in Cats
Once your veterinarian has determined the cause of your cat’s reaction, they will discuss treatment options with you. Usually, mild cases will not require treatments unless it is an antihistamine and/or corticosteroid to stop itching or sneezing. Anti-inflammatories may be given to reduce swelling. 
If your cat has developed a more serious adverse reaction or allergy to the rabies vaccine, your veterinarian will need to administer treatments. These treatments will probably be supportive care in the form of intravenous fluid therapy, oxygen therapy and close monitoring of their vital signs. 
If your cat has gone into anaphylactic shock, emergency measures will need to be taken to keep your cat’s airways open so they are able to breathe. Oxygen support will most likely be necessary. Epinephrine will be given as well as antihistamines.

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Recovery of Adverse Reaction to Rabies Vaccine in Cats
Your veterinarian can help you protect your cat from developing a serious rabies vaccine allergy, or another reaction once they know that your cat is sensitive to the vaccine.  If your cat has had a mild reaction in the past, it is important to mention that to your veterinarian.   Also, ask your veterinarian if three year rabies vaccine will suffice or if your county requires a yearly vaccine. 
Prior to giving the rabies vaccine, ask your veterinarian about administering an antihistamine to reduce the allergic reaction that your cat experiences if your cat has had any reactions in the past.  
Adverse Reaction to Rabies Vaccine Questions and Advice from Veterinary Professionals
Short hair cat
Four Years

13 found this helpful

13 found this helpful

My pet has the following symptoms:
Seizure
He had rabies & FVRCP 3 days ago. Not eating much and very sleepy. Today he had a seizure. He hasn’t drank or eat anything today
Sept. 28, 2020
Answered by Dr. Michele K. DVM
13 Recommendations
Thank you for your question. It would be best to have you cat seen right away by a veterinarian if he is having seizures, and not eating. That would be an unusual reaction to a vaccination, but he needs medical care, regardless. I hope that he is okay.
Oct. 8, 2020
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domestic short hair
2.5 Years

0 found this helpful

0 found this helpful

My pet has the following symptoms:
Unable To Walk After Vaccine
my parents have a cat. she was getting lethargic and not herself. they took her to a veterinarian after seeing green mucus from her nose. the vet wouldn’t treat her without a rabies vaccine and determined she had a bad sinus infection. two days later she had some violent spasming while meowing very loudly. we took her to an emergency clinic and they found she had a very high white cell blood count and they changed her antibiotics. two days later, she cannot walk. her back legs wont work properly with her paws curling under. she is very alert, eats and drinks fine, and uses litter
Sept. 24, 2020
Answered by Dr. Michele K. DVM
0 Recommendations
Thank you for your question. I apologize for the delay, this venue is not set up for urgent emails. I hope that your pet is feeling better. If they are still having problems, It would be best to have your pet seen by a veterinarian, as they can examine them, see what might be going on, and get any testing or treatment taken care of that might be needed.
Oct. 25, 2020
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Feline
Six Years

0 found this helpful

0 found this helpful

My pet has the following symptoms:
Lethargy
My cat received a rabies vaccination three weeks ago and is now acting lethargic and weak out of nowhere. Could this be the vaccination? Should we have him seen or wait?
July 31, 2020
Answered by Dr. Michele K. DVM
0 Recommendations
Thank you for your question. It is quite unlikely that the lethargy that you are noticing now has anything to do with the vaccination three weeks ago. It seems that there might be something new going on, and it would probably be a good idea to have your cat seen by a veterinarian. They will be able to examine your cat and see why he is lethargic and weak, and let you know more what might be going on and if any testing needs to be done. I hope that he is okay.
July 31, 2020
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short hair cat
7 months

6 found this helpful

6 found this helpful

My pet has the following symptoms:
Drooling
We got a kitten on Saturday and took her to the vets for her shots on Monday. She got her rabies, distemper, and flea and tick at 4 pm. It is now 9 pm and she is drooling what looks to be mucus and a lot of it. I know that stress can be a cause of drooling and shes in a new environment with a dog and got her shots today. but i'm still really worried that it might be a reaction to the treatments from earlier today.
July 21, 2020
Answered by Dr. Michele K. DVM
6 Recommendations
Thank you for your question. I'm sorry that she is having problems. You are right, drooling can be a result of stress or not feeling well. If she is able to eat and drink overnight, she may be fine. It would be best to give her a quiet place to eat and drink, so that she can rest., and watch her. If she is vomiting, does not want to eat overnight, or the drooling continues, then it would be best to have her seen by a veterinarian in the morning. I hope that all goes well for her.
July 21, 2020
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Short hair housecat
8 Years

1 found this helpful

1 found this helpful

My pet has the following symptoms:
Limping, Lathargic, Extreme Curve To His Spine,
We recently got a kitten. I took both cats to get up to date on their vaccines. It was the first time my 8 year old cat had been to the vet since he was neutered at 6 months. At first I thought he was limping because the kitten was wrestling too hard with him but now I'm concerned it's something else.
July 12, 2020
Answered by Dr. Ellen M. DVM
1 Recommendations
Hello, thank you for your question. I am sorry to hear that your cat is limping. Without examining your cat it is very hard to know for sure what might be going on. What you describe could be consistent with a minor injury due to playing too rough, but if he's lethargic and still limping, I am concerned. It could be that your kitten bit him and the bite wound is now infected - these can sometimes be hard to see, but can be very painful. It's also possible that he has bone or joint damage from something. I recommend that you schedule another visit with your veterinarian. They will likely want to examine him to see if there is any evidence of a pocket of infection. They may also recommend an x-ray of that leg to make sure there is nothing going on with the bone or in a joint. They should be able to give him some medication to help with his discomfort as well. I hope that your cat starts feeling better soon!
July 12, 2020
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American Shorthair
Rascal
19 Years

0 found this helpful

0 found this helpful

My pet has the following symptoms:
Hair Loss
Took my 19 yr old cat for a rabies shot three days ago. He has fine before I took him to the vet and now he keeps running out the house to be outdoors (he never liked being outside) and when I got him back from the vet he had a wet spot at the site of the shot, but now he has a bald spot on the same place.
domestic short hair
Bobbie
3 Years

0 found this helpful

0 found this helpful

My pet has the following symptoms:
Swelling
Limping
Excessive Licking
Sensitivity To Injection Site
My cat has a reaction to his first 3 year rabies vaccine. (he’s only 3 so the first vaccine was a 1 year) I saw a new vet at my usual practice and she gave my cat the rabies vaccine into his foot. He had immediate swelling and had developed a bump that has not gone away (he got the vaccine a few months ago!) He still seems to have sensitivity to the area and will occasionally limp and excessively lick the area. I am aware that a lot of vets like to give rabies vaccines in different areas each time to lessen the chance of developing sarcoma, but I have never seen if given in the foot area. My boy also has cerebellar hypoplasia. I’m wondering if since he already is a bit deformed and has motor skill issues, If the vaccine could’ve affected his motion in that foot? I’ve brought him back to that vet and a different vet at our practice and they seem to have no idea to what is wrong with his foot. I’m also wondering that since CH is a neurological condition, if I should only get him 1 year rabies vaccines instead of three years? I’d love to hear back from anyone who’s cat has had vaccines given in the foot/leg before, or if they’re CH cat has been negatively effected from vaccines. I’ll be scheduling another follow up with a different vet office to see if there’s anything I can do for my little buddy! Hope everyone’s cats are happy and healthy :) *I posted this before but I’m an idiot and put the wrong email!
Domestic shorthair
Bobbie
3 Years

0 found this helpful

0 found this helpful

My pet has the following symptoms:
Swelling
Limping
Sensitivity To Injection Site
My cat has a reaction to his first 3 year rabies vaccine. (he’s only 3 so the first vaccine was a 1 year) I saw a new vet at my usual practice and she gave my cat the rabies vaccine into his foot. He had immediate swelling and had developed a bump that has not gone away (he got the vaccine a few months ago!) He still seems to have sensitivity to the area and will occasionally limp and excessively lick the area. I am aware that a lot of vets like to give rabies vaccines in different areas each time to lessen the chance of developing sarcoma, but I have never seen if given in the foot area. My boy also has cerebellar hypoplasia. I’m wondering if since he already is a bit deformed and has motor skill issues, If the vaccine could’ve affected his motion in that foot? I’ve brought him back to that vet and a different vet at our practice and they seem to have no idea to what is wrong with his foot. I’m also wondering that since CH is a neurological condition, if I should only get him 1 year rabies vaccines instead of three years? I’d love to hear back from anyone who’s cat has had vaccines given in the foot/leg before, or if they’re CH cat has been negatively effected from vaccines. I’ll be scheduling another follow up with a different vet office to see if there’s anything I can do for my little buddy! Hope everyone’s cats are happy and healthy :)
Dlh
Gizmo
5 Years

0 found this helpful

0 found this helpful

My pet has the following symptoms:
Throwing Up, Listless (Somewhat)
My neutered male cat approximately five years old had a rabies vaccine today and has been throwing up since and sleeping mostly. I talked to him and he is responding but this has never happened before
Domestic shorthair
Misha
10 Years

0 found this helpful

0 found this helpful

My pet has the following symptoms:
Spinal Break
My kitty Misha seemed fine after her rabies injection. It was given in her lower back an inch or two away from her spine. About 5 years later, while I was on vacation, my sitter called to say I needed to come home right away. Misha's back broke. The vet said that a sarcoma formed in the area of her vaccination and ate through her spine. There was nothing they could do at that point. He shared with me that they were finding more instances of injection site sarcomas. This was in 1996. I have refused the injection for all my cats since then but recently my kitty Murray required dental surgery and the vet said by law I had to vaccinate him and if I didn't and he bit someone in the office, he would be put down immediately, so I relented. They said they now do the injection into the leg so if FISS occurs, they can easily remove the leg and not lose the cat. This is disgusting and very disappointing. The laws need to change. All my cats are indoor cats, I never board them and they don't come in contact with any other animals. How can they continue this barbaric procedure.
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