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- Increased thirst (polydipsia)
- Frequent urination (polyuria)
- Increased appetite (polyphagia)
- Weight loss (even though he is eating regularly)
- Weakness
- Lethargy and fatigue
- Restlessness
- Muscle twitching
- Depression
- Dehydration
- Vomiting
- Seizure
- Daze, confusion, and unresponsiveness
- Rapid breathing (tachypnea)
- Coma
- Death
- Insulin resistance
- Insulin effectiveness
- Diabetic ketoacidosis
- Hyperosmolar nonketotic diabetes
- Hypoglycemia
- Hyperglycemia
- Hyperadrenocorticism
- Infection such as in the urinary tract
- Hypothyroidism
- Pancreatitis
- Severe obesity
- Neoplasia
- Inactive insulin
- Improper technique of giving your dog the insulin
- Impaired insulin absorption
- Undiagnosed diabetes
- Inadequate dosage of insulin
- Ineffectiveness or resistance
- Impaired glucose excretion in urine
- Undiagnosed hyperglycemia
- Dangerously low blood glucose
- Too much insulin
- Chronically high blood glucose
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