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What are Zinc-Responsive Dermatosis?

A rare scaling skin disorder, zinc-responsive dermatosis is the result of zinc deficiency, zinc malabsorption or incorrect utilization of zinc. Zinc is imperative for over 300 enzymes, structural proteins and hormones. It is critical for numerous biological functions, to include regulating the immune system’s response, cell replication and regenerating the intestinal mucosa, adjustment in regards to keratogenesis and the healing of wounds, maintaining typical reproductive function, turning over epithelial cells that are needed to keep skin, hair and nails healthy and the sharpness of the dog’s taste and smell. When zinc deficiency occurs, certain immune responses are reduced (those handled by T cells) and antibody production is decreased.

Zinc-responsive dermatosis may occur as a result of several causes and can lead to redness, scaling, crusting and hair loss among other symptoms.


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Symptoms of Zinc-Responsive Dermatosis in Dogs

In both Syndrome I and Syndrome II, redness (as a result of congestion in the capillaries in the lower layers of the skin) will be present at the mucocutaneous junction and pressure points. In addition, scaling, crusting, hair loss, pyoderma and lichenification mainly involving your dog’s head can occur.

Should your dog experience a severe case of either syndrome, you may see the following:

  • Lack of interest in eating
  • Stunted growth
  • Lethargy


Several clinical presentations of zinc-responsive dermatosis are seen in dogs:

Syndrome I - Usually only found in northern breeds like Siberian Huskies and Alaskan Malamutes; this condition is inherited and results in something going awry in the absorption or metabolization of zinc

Syndrome II - Occurs in quickly growing puppies of a larger breed that ingest a diet that is high in phytate and deficient in zinc or a diet that has parts that can inhibit zinc being absorbed

Generic Dog Food Disease - Scaling and crusting as developed in some dogs after being fed a generic dog food for two to four weeks; these foods did not meet the National Research Council requirements and did not have an optimal level of zinc (in addition to the skin symptoms, puppies with this condition had fever, depression and swollen lymph nodes)

There are also hereditary zinc deficiencies that can occur, for example:

  • Nasal hyperkeratosis in Golden Retrievers
  • Congenital follicular parakeratosis in Rottweilers and Siberian Huskies

Causes of Zinc-Responsive Dermatosis in Dogs

Syndrome I is the result of a genetic defect in your dog’s intestinal absorption. Syndrome II occurs when large-breed puppies consume a diet that is high in phytate and deficient in zinc; or the diet may include things that can inhibit zinc absorption, leading to the deficiency. Generic dog food disease can occur when generic dog food that does not include the appropriate amount of zinc is fed to your dog for as little as two weeks.

Diagnosis of Zinc-Responsive Dermatosis in Dogs

Should you notice any unusual symptoms in your dog, you will want to visit your veterinarian. Your dog will receive a complete physical examination and your veterinarian may choose to take samples of his blood and skin for further analysis. Zinc-responsive dermatosis can be diagnosed by looking at affected skin cells under a microscope as well as reduced amounts of zinc in the dog’s blood and his response to treatment. It has been found that low amounts of zinc in the serum and hair of your dog is not conclusive and must be seen in conjunction with a positive response to treatment.

Conditions that your veterinarian will look to rule out include:

  • Lethal acrodermatitis (seen in Staffordshire Bull terriers)
  • Demodectic mange
  • Vitamin A-responsive dermatosis
  • Lupus erythematosus
  • Malassezia dermatitis

Treatment of Zinc-Responsive Dermatosis in Dogs

Supplementing zinc and retinoid is typically successful for dogs experiencing zinc-responsive dermatosis. Zinc may be administered as an oral supplement on a daily basis and should the case be severe, your veterinarian may recommend your dog receive an injection of zinc sulfate. Your dog should undergo treatment for a month to see how he is responding to treatment. Should it not lead to improvement, your veterinarian may want to increase the dose by 50%. Antimicrobial therapy may be recommended as well as regular bathing with keratolytic shampoos like sulfur and salicylic acid.

Recovery of Zinc-Responsive Dermatosis in Dogs

Dogs with Syndrome I have a fair prognosis though it is recommended that they not breed out of concern for passing on the condition. An excellent prognosis is expected for dogs experiencing Syndrome II. Symptoms will usually resolve after a few weeks of your dog receiving zinc supplements. 

Your veterinarian will likely recommend a follow up appointment so that he can determine whether treatment is effective and make treatment changes if necessary. Working closely with your veterinarian is important to ensure the best outcome for your dog.

Zinc-Responsive Dermatosis Questions and Advice from Veterinary Professionals

Siberian Husky
2 Years
Mild condition
0 found helpful
Mild condition

Has Symptoms

Slight Lethargy
Fungal infection
hyper keratatosis (foot)

2 year old siberian husky. She has had hyperkeratosis for maybe a year or more (I thought it was normal until now). Not extremely bothersome to her but I bought boots and I moisterize w/ shea butter dog moisterizer. She has a fungal infection in one foot (hair loss extremely red), and dandruff. I've been treating with antifungal shampoo and topical antifungal for the foot. Shes 43 lbs, how should I supplement? She has costco natures doman (grain free, salmon based, omega supplement) with Zinc 150 mg/kg Minimum. Please advise

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7 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Hair Loss
Hair Loss, crusting
Hair Loss, crusting scratching

Our husky was just diagnosed with ZRD and I am finding conflicting information on what to feed her and what not to feed her. I read no phytates and then another says feed brown rice, lentils etc that are not ok in other information. Please clarify and also why are some saying varying kinds of zinc supplements yet vet said zinpro?

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
There is conflicting information online for almost every medical condition with many people putting out misinformation based on their own opinion (this is how fads start); I’ve linked below two articles from reputable sources on Zinc-Responsive Dermatosis which will give you an overview on what to do, feed and supplement. Regards Dr Callum Turner DVM

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Siberian Husky
1 Year
Fair condition
0 found helpful
Fair condition

Has Symptoms

Scaling skin around eyes
Hair loss around eyes and mouth
Appears dark, sometimes red
Generally not itchy, ocassional

Is supplementing my dog with ZRD by administering 50mg zinc with breakfast and 50mg of zinc with dinner enough? She also receives 1200mg or more of salmon oil, a few carrots daily, sometimes dog-friendly fruit and occasionally we give raw chicken livers or other meats. She is on a wheat/grain-free diet and eats a quality food with about 75mg zinc per serving. We give her 1-2 eggs per day as well.

Dr. Michele King, DVM
Dr. Michele King, DVM
1611 Recommendations
It sounds like you are treating Leia's ZRD appropriately. Unfortunately, without knowing her weight, I can't comment on the dosage of medication that she is getting. It would be best to check with your veterinarian, as they are familiar with her and would have a current weight.

Hello! Could you please tell me what is a Zinc norma in blood of Siberian husky (3 years old)?
Thank you very much in advance.

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Border Collie
14 years next month
Serious condition
0 found helpful
Serious condition

Has Symptoms

severe hair loss
Bright in herself although at first very lethargic
Skin has crusty lesions on

My dog has been treated for a skin condition for nearly 12 months, and if anything is worse! She us currently on steroids and antibiotics to try and control It, but it's not doing anything. She has had blood tests and skin scrapes but nothing shows up.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations
In chronic dermatology cases it is usually useful to see a Dermatologist or to have a biopsy sample of the edge of a lesion sent for histopathology to see if an underlying cause can be determined. If skin scraping is unproductive, a culture and sensitivity test may indicate any long term infection which may be causing these lesions; other causes may include internal disease (normally picked up on blood tests) or liver issues (again blood test). Regards Dr Callum Turner DVM

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