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- Anemia Due to Enlarged Blood Cells in Dogs
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- Poor appetite
- Weight loss
- Lethargy
- Lack of stamina
- Weakness
- Rapid heart rate (tachycardia)
- Rapid breathing (tachypnea)
- Paleness of mucus membranes, especially notable around the gums
- Blood in the stool
- This is a condition in which the bone marrow is full of megaloblasts or poorly developed blood cell precursors
- It leads to megaloblastic anemia
- As a diagnosis this indicates some degree of enlargement in the blood cells
- It may be present without anemia (this is an inherited condition in poodles)
- In humans, high levels of macrocytes generally indicate megaloblastosis in the bone marrow, but this correlation isn’t as remarked in dogs
- Most veterinarians use some degree of macrocytosis as a preliminary indication of regenerative anemia since strong bone marrow stimulation can also create immature, enlarged blood cells
- Other factors, like white blood cell and platelet counts, would also be relevant to the veterinarian’s interpretation of macrocytosis
- More common in some breeds
- Giant Schnauzers
- Border Collies
- Beagles
- Australian Shepherds
- which inhibit folate absorption
- Methotrexate (cancer medication)
- Hydroxurea
- Trimethoprim-sulpha
- Fenbendazole
- Quinidine
- Some anti-convulsion medication
- In dogs this only leads to anemia in prolonged cases
- This isn’t common in dogs, although it has been created in laboratory situations
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