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What is Imidacloprid Toxicity?

Imidacloprid has been approved by the EPA for use on dogs and will kill fleas already on your dog within 12 hours of application. It is applied topically and will spread through your dog’s hair follicles and onto their skin, protecting them from fleas for up to one month. 

Imidacloprid is generally safe to use on dogs over seven weeks of age and any size. Symptoms of toxicity are rarely seen, unless your dog licks the imidacloprid directly. Then excessive salivation can occur as well as gastrointestinal upset and muscle weakness. Toxicity is more prevalent in dogs that are old or sick. Smaller dogs also are at a higher risk of toxicity.

Imidacloprid is a chloronicotinyl nitroguanidine insecticide that is generally used for pest control on crops, vegetables and fruits, termite control and flea control. For dogs, imidacloprid is sold under the brand name of Advantage and is used as a topical flea control once monthly. Imidacloprid binds to the acetylcholine receptor on the postsynaptic part of the nerve cells of the flea; this will cause paralysis and death of the flea.

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Symptoms of Imidacloprid Toxicity in Dogs

Imidacloprid toxicity in dogs is rare, but can occur especially if your dog licks the imidacloprid. There have been cases where the topical application has caused illness as well. It is best to only apply imidacloprid to healthy dogs that are over seven weeks old. If you notice any of these symptoms after applying imidacloprid to your dog, contact your veterinarian immediately for assistance.

  • Hives 
  • Itching
  • Respiratory distress
  • Congestion
  • Shock
  • Excessive salivation
  • Vomiting
  • Diarrhea
  • Muscle weakness
  • Incoordination
  • Muscle tremors
  • Ear twitching

Causes of Imidacloprid Toxicity in Dogs

Imidacloprid is an insecticide and therefore can cause toxicity in your dog. This is especially the case if your dog is sick or already debilitated from an illness. Small dogs can also be at risk of developing toxicity to imidacloprid. Dogs that have abnormally low body temperatures are also at risk of toxic poisoning. Dogs with sensitive skin are also prone to developing toxicity to imidacloprid. 

Although it is approved by the EPA for use on dogs, imidacloprid is a chloronicotinyl nitroguanidine insecticide that was first used in termite control and pest control on crops.

Diagnosis of Imidacloprid Toxicity in Dogs

When diagnosing imidacloprid toxicity, your veterinarian will first take a thorough medical history and ask you about the symptoms that you have seen. They will also want to know if any sprays or other topical flea treatments have recently been used on your dog. 

A full physical evaluation will be performed along with a complete blood count, urinalysis and biochemistry panel. This will help determine the exact cause of your dog’s ailment and if there has been internal damage done. 

Many times, your dog will experience skin irritation and/or excessive salivation or drooling. Your veterinarian will be searching for the cause and also how to quickly treat your dog to stop the toxic poisoning.

Treatment of Imidacloprid Toxicity in Dogs

Once your veterinarian has diagnosed imidacloprid toxicity in your dog, your veterinarian will discuss treatment options. Most of the time mild symptoms are self limiting or they will simply require a thorough bath, using a mild shampoo, to remove the toxins from your dog’s coat and skin. 

More severe symptoms that seem to affect your dog’s neurological system will most likely require hospitalization and supportive care. Supportive care will probably include intravenous fluids, nutritional therapy and treating the symptoms as they present. Your dog will also need to have their body temperature regulated while they are hospitalized. Your veterinarian will order your dog be thoroughly bathed to remove as much of the toxins from their coat and skin. This will keep your dog from absorbing more of the toxins.

Your veterinarian will continue to monitor your dog’s progress and perform testing to ensure that no long term damage has been done to your dog. Once your dog is on the road to recovery, your veterinarian will release them from the hospital and you will be able to continue their care at home.

Recovery of Imidacloprid Toxicity in Dogs

When continuing at home care during your dog’s recovery be sure to follow any instructions given by your veterinarian. Any medications prescribed need to be administered as directed. 

The proper application of imidacloprid is important to prevent your dog from having a reaction, closely follow the directions and if you are unsure about a product consult your veterinarian.

Imidacloprid Toxicity Questions and Advice from Veterinary Professionals

DANNY
Cavachon
10 Years
Serious condition
2 found helpful
Serious condition

THIS IS THE STORY OF MY 2 CAVACHON LIL BUDDIES DANNY 10 1/2 DOMINIC 5. I JUST LOST THE 2ND 1 DOMINIC YESTERDAY SATURDAY IN THE LAST 21 DAYS PLEASE READ.

DEAR Bayer : Makers of Seresto flea & tick collar

I am writing this letter telling you at Bayer my experience with your Seresto collars. I bought 4 collars for my 4 dogs on 5/6/19 at the Abington animal hospital in Abington Ma. I have a female 13 1/2 yr old Cocker spaniel, a male 2 yr old Golden doodle, & 2 male Cavachons 10 1/2 & yrs old. On Thursday 6/6/19 @ 3am my 5 yr old Cavachon Dominic had a seizure, we immediately took the collar off him along with the Danny our other Cavachon & had our son at home take the collars off our other 2 dogs. Dominic vomited pooped & had muscle weakness during the night. he seemed to bounce back some the next day. Later that same day 6/6/19 at 4:15 pm my 10 1/2 yr old Cavachon Danny had a seizure. We took him to the Country Veterinary clinic in carver ma near my seasonal camper in carver. There he was examined They did blood work & checked him out & couldn't find & issue other than hi sugar & phospherous levels. They said try feeding both dogs boiled chicken & rice or boiled hamburgh & rice or pasta. later that night Dominic had another episode where he fell over & vomited & pooped all over our campers deck. He was lethargic all day on Friday 6/7/19, He would not eat anything. The 10 1/2 yr old Danny was lethargic early in the day he perked up in the mid afternoon & ate chicken & pasta while Dominic remained lethargic.

On the morning of Saturday 6/8/19 my 10 1/2 yr old Danny had another seizure with coughing. He was laying down in our camper kitchen floor as we patted him to bring him out of it. Suddenly his legs started to stiffen & started wrenching back & forth towards each other as he died at my feet. We brought Danny's body back to the vet at the Country Vet clinic that morning when they opened. The Dr took him in the back room to do an autopsy after they closed at noon. We came back at 11am with Dominic who remained lethargic & still was not eating. he did blood work & iv fluids to hydrate him. Dominic's blood work showed hi phospherous levels like Danny's but his blood sugar was normal compared to Danny.he thought Dannys hi sugar was caused by the seizure. Dr Simpson's autopsy did not show any abnormalities of any of Danny's organs kidneys liver, lungs, stomach. He had some thickening of the arteris around his heart which may have caused the cough he had along with the hi pollen this spring. Dr Simpson still could not find a reason for all that had happened to our cavachons & the seizures that they had 15 hours apart from each other.

My dogs are always with us they got into nothing that might cause these problems what so ever. We looked up the ingredients of the Seresto collars espescially the pesticide used by the name IMIDACLOPRID. We found that every symptom both our little dogs had can be caused by this pesticide that you use in these collars. the only thing we did different with our dogs is to get them these Seresto collars. Now my Danny is dead & as i write this on 6/17/19. My Dominic has showed some improvement but is still far from the active & playful dog he was before his seizure on 6/6/19. We took Dominic back to the vet on Monday 6/10/19 where he received more iv fluids & shots of prednisone & an anti neahsea to help his appetite out. he also gave us pills of both meds to give him for 5 days. The vet gave Dominic as he went 5 days without eating but just drinking some special dog food. On Wednesday 6/13/19 Dominic finally ate some without us feeding him. His back legs were still weak where we had to carry him down to go the bathroom. On Thursday 6/13/19 he finally went down then back up the stairs on his own, the same on Friday 6/14/19. By the end of friday & after a few short walks his back legs were still weak trying to stand. He finally moved his bowels on Friday 6/14/19 2 times. On Saturday 6/15/19 his birthday at around 5:10 pm he kind of rolled over & couldn't get up. My wife picked him up but he seems just dead tired. He has been eating a little better each day but has continued to vomit on occassion. Dominic is at best 1/2 of what he was before hi 1st seizure on 6/6/19 @ 3AM. i'm just hoping there's no neurologogical damage IMIDACLOPRID can cause. The vet told us he could not rule out the collars from causing these symptoms in our beloved pets Danny & Dominic. My regular vet of the Abington animal hospital where we bought the collars. He basicly said it's like hitting the lottery it's possible the collars may have caused it. both vets said what are the odds of 2 dogs 1 month after putting these collars on them having seizures 15 hours apart from each other.

My wife & i truly believe your collar killed my prescious dog Danny& has almost caused Dominic to die twice on 6/8/19 & 6/9/19. We have spent $285 for the 4 collars we bought our dogs that wore them for 1 month to the day 5/6/19 - 6/6/19. It killed 1 dog & another is still fighting the effects of them as i write this letter on 6/17/19. Then throw in my vet bills treating 2 dogs & getting another 1 checked out its over $1,500. I will tell you this now i will tell every pet owner i know in person & others on social media what i truly believe what your Seresto flea & tick collar did to our beloved family pets.I'm also sending with this letter my $15 rebate for each of the collars i purchased for my 4 dogs. Wow isn't that nice, a big $60 back for my poor dead Danny & possibly another dog dying down the road or never being his playful energenic self again.

Thank you for a horrible 2 weeks. This is the letter i sent to Bayer earlier last week along with my rebate mail in for the collars. I cant wait to hear from them if they even do.

As of yesterday 6/29/19 Dominic passed away after not eating for the last 5 days on his own . My wife & i were actually force feeding him by spoon he was throwing it up meds & food then the water. He got an anti nausea shot on 6/27/19 by the vet along with pills for the same. He just got worse & worse till he passed. Now he's back with Danny in doggie heaven as he's also been grief stricken from Danny's passing 3 weeks ago to the day. Dom Dom as we called him was the black & white dog. these were my best dogs ever Danny got me thru 10 surgeries over a 9 year period with Dom Dom also there for a few. these cavachons are the most loving & happy dogs i have ever had & now they're gone over a chemical collar that can kill your dog by the pesticides in them. I truly believe it killed them both & feel the need to warn all you pet owners. Right now my beloved dom dom is in my fridge because the other hospital i brought him too after he passed didnt have a fridge only freezers. I am going to bring him to the treating vet tomorrow monday july 1st so he can autopsy Dominic if he has been in a freezer thay can't do it.

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DOMINIC
Cavachon
5 Years
Serious condition
1 found helpful
Serious condition

Has Symptoms

Seizures
Seizures DIAHREA VOMITTING
Seizures DIAHREA

THIS IS THE STORY OF MY 2 CAVACHON LIL BUDDIES DANNY 10 1/2 DOMINIC 5. I JUST LOST THE 2ND 1 DOMINIC YESTERDAY SATURDAY IN THE LAST 21 DAYS PLEASE READ.

DEAR Bayer : Makers of Seresto flea & tick collar

I am writing this letter telling you at Bayer my experience with your Seresto collars. I bought 4 collars for my 4 dogs on 5/6/19 at the Abington animal hospital in Abington Ma. I have a female 13 1/2 yr old Cocker spaniel, a male 2 yr old Golden doodle, & 2 male Cavachons 10 1/2 & yrs old. On Thursday 6/6/19 @ 3am my 5 yr old Cavachon Dominic had a seizure, we immediately took the collar off him along with the Danny our other Cavachon & had our son at home take the collars off our other 2 dogs. Dominic vomited pooped & had muscle weakness during the night. he seemed to bounce back some the next day. Later that same day 6/6/19 at 4:15 pm my 10 1/2 yr old Cavachon Danny had a seizure. We took him to the Country Veterinary clinic in carver ma near my seasonal camper in carver. There he was examined They did blood work & checked him out & couldn't find & issue other than hi sugar & phospherous levels. They said try feeding both dogs boiled chicken & rice or boiled hamburgh & rice or pasta. later that night Dominic had another episode where he fell over & vomited & pooped all over our campers deck. He was lethargic all day on Friday 6/7/19, He would not eat anything. The 10 1/2 yr old Danny was lethargic early in the day he perked up in the mid afternoon & ate chicken & pasta while Dominic remained lethargic.

On the morning of Saturday 6/8/19 my 10 1/2 yr old Danny had another seizure with coughing. He was laying down in our camper kitchen floor as we patted him to bring him out of it. Suddenly his legs started to stiffen & started wrenching back & forth towards each other as he died at my feet. We brought Danny's body back to the vet at the Country Vet clinic that morning when they opened. The Dr took him in the back room to do an autopsy after they closed at noon. We came back at 11am with Dominic who remained lethargic & still was not eating. he did blood work & iv fluids to hydrate him. Dominic's blood work showed hi phospherous levels like Danny's but his blood sugar was normal compared to Danny.he thought Dannys hi sugar was caused by the seizure. Dr Simpson's autopsy did not show any abnormalities of any of Danny's organs kidneys liver, lungs, stomach. He had some thickening of the arteris around his heart which may have caused the cough he had along with the hi pollen this spring. Dr Simpson still could not find a reason for all that had happened to our cavachons & the seizures that they had 15 hours apart from each other.

My dogs are always with us they got into nothing that might cause these problems what so ever. We looked up the ingredients of the Seresto collars espescially the pesticide used by the name IMIDACLOPRID. We found that every symptom both our little dogs had can be caused by this pesticide that you use in these collars. the only thing we did different with our dogs is to get them these Seresto collars. Now my Danny is dead & as i write this on 6/17/19. My Dominic has showed some improvement but is still far from the active & playful dog he was before his seizure on 6/6/19. We took Dominic back to the vet on Monday 6/10/19 where he received more iv fluids & shots of prednisone & an anti neahsea to help his appetite out. he also gave us pills of both meds to give him for 5 days. The vet gave Dominic as he went 5 days without eating but just drinking some special dog food. On Wednesday 6/13/19 Dominic finally ate some without us feeding him. His back legs were still weak where we had to carry him down to go the bathroom. On Thursday 6/13/19 he finally went down then back up the stairs on his own, the same on Friday 6/14/19. By the end of friday & after a few short walks his back legs were still weak trying to stand. He finally moved his bowels on Friday 6/14/19 2 times. On Saturday 6/15/19 his birthday at around 5:10 pm he kind of rolled over & couldn't get up. My wife picked him up but he seems just dead tired. He has been eating a little better each day but has continued to vomit on occassion. Dominic is at best 1/2 of what he was before hi 1st seizure on 6/6/19 @ 3AM. i'm just hoping there's no neurologogical damage IMIDACLOPRID can cause. The vet told us he could not rule out the collars from causing these symptoms in our beloved pets Danny & Dominic. My regular vet of the Abington animal hospital where we bought the collars. He basicly said it's like hitting the lottery it's possible the collars may have caused it. both vets said what are the odds of 2 dogs 1 month after putting these collars on them having seizures 15 hours apart from each other.

My wife & i truly believe your collar killed my prescious dog Danny& has almost caused Dominic to die twice on 6/8/19 & 6/9/19. We have spent $285 for the 4 collars we bought our dogs that wore them for 1 month to the day 5/6/19 - 6/6/19. It killed 1 dog & another is still fighting the effects of them as i write this letter on 6/17/19. Then throw in my vet bills treating 2 dogs & getting another 1 checked out its over $1,500. I will tell you this now i will tell every pet owner i know in person & others on social media what i truly believe what your Seresto flea & tick collar did to our beloved family pets.I'm also sending with this letter my $15 rebate for each of the collars i purchased for my 4 dogs. Wow isn't that nice, a big $60 back for my poor dead Danny & possibly another dog dying down the road or never being his playful energenic self again.

Thank you for a horrible 2 weeks. This is the letter i sent to Bayer earlier last week along with my rebate mail in for the collars. I cant wait to hear from them if they even do.

As of yesterday 6/29/19 Dominic passed away after not eating for the last 5 days on his own . My wife & i were actually force feeding him by spoon he was throwing it up meds & food then the water. He got an anti nausea shot on 6/27/19 by the vet along with pills for the same. He just got worse & worse till he passed. Now he's back with Danny in doggie heaven as he's also been grief stricken from Danny's passing 3 weeks ago to the day. Dom Dom as we called him was the black & white dog. these were my best dogs ever Danny got me thru 10 surgeries over a 9 year period with Dom Dom also there for a few. these cavachons are the most loving & happy dogs i have ever had & now they're gone over a chemical collar that can kill your dog by the pesticides in them. I truly believe it killed them both & feel the need to warn all you pet owners. Right now my beloved dom dom is in my fridge because the other hospital i brought him too after he passed didnt have a fridge only freezers. I am going to bring him to the treating vet tomorrow monday july 1st so he can autopsy Dominic if he has been in a freezer thay can't do it.

I am so very sorry for your loss. Our pets are the most loyal, and unconditional love we receive here on Earth. My heart bled and eyes cried, reading your story. I almost ordered some IMIDACLOPRID, trying to save money, as my poor 14 year old Rat Terrier (Rabbit) is having fleas for the first time in years! Your story just may have saved me money in a way I will never be able to repay you! Rabbit suffers from Epilepsy, so seizures are not uncommon here, but he's been on medication for most of his life, so they are few and far between. His sister from another litter, Nancy, is 16 and already quite ill, not expected to last out the week. Fortunately, fleas don't seem attracted to her.
In the past, I used Frontline, many years ago, causing a hives reaction in Rabbit that was horrendous! My groomer had me switch to Advantage, but I have not used it for the past year, due to no fleas, but considered it to be 'safe', .....until now. Since the same active ingredient (IMIDACLORPID) is in Advantage, I was going to try saving money by ordering a large bottle, from Amazon. Now, I thank God I came across this doing research!! There are several very natural remedies on YouTube...think I'll stick to that.
Again, thank you from the bottom of my heart! God bless you!

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Scottie
Scottish Terrier
11 Years
Serious condition
0 found helpful
Serious condition

Has Symptoms

scratching and chewing paws and legs

Is there a flea/tick repellent that will kill the pests but not my dog. Imidacloprid products are dangerous to my Scottish Terrier (they caused hot spots and liver damage).

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations

Imidacloprid (Advantage) like other topical spot on treatments are safe for use in dogs although a small proportion of dogs may be sensitive to particular ingredients; if you are concerned about the mainstream canine spot on treatments, there are natural products containing pyrethrin extracts from the chrysanthemum plant which you may consider but are less effective and need to be sprayed on every few days or weeks to be effective (follow the instructions carefully). I would try using a different product like Frontline (fipronil) to see if there are any negative effects from use. Regards Dr Callum Turner DVM

Since they each act differently and effectively against fleas, why isn't a product available with fipronil AND imidacloprid?

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Emmy & Hobbes
beagles
6 Years
Fair condition
0 found helpful
Fair condition

Has Symptoms

No symptoms as of yet
Minor

I am looking for only topical preventatives for my beagles. We are using K9 Advantix II which is a topical and contains IMIDACLOPRID 8.8% for flea, tick and mosquito control. I would also like to use Advantage Multi which is a topical and contains IMIDACLOPRID and MOXIDECTIN. Both products are made by Bayer.

Is it safe to use both topicals. Also, since K9 Advantix II kills mosquitos, does it already prevent heartworm as it is mosquitos which transmit?

Also, I had to put symptoms etc. in the boxes below but my dogs have none.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3320 Recommendations

The moxidectin may be used as a direct prevention for heartworm and is also a treatment for microfilariae in dogs; imidacloprid is a mosquito repellent which will also prevent heartworm. I understand that you would like to prevent fleas, ticks, heartworm and mosquitoes but I wouldn’t recommend using both products at the same time as they both use imidacloprid; using the Advantage Multi would be best due to its increased efficacy against heartworm due to the moxidectin, although the product doesn’t offer prevention against ticks. Regards Dr Callum Turner DVM

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