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What is Transmissible Venereal Tumor?

While this type of tumor has been diagnosed throughout many areas of the world, it seems to favor temperate climates, such as the United States, Southern Europe, Asia, Africa, and the Caribbean. It is believed that transmissible venereal tumors (TVT) are the oldest known form of cancer, and first emerged 11,000 years ago. All TVT tumors contain DNA belonging to the first dog infected with this cancer, and researchers are analyzing the mutations seen in these tumors to figure out how TVT first developed and spread.

Transmissible venereal tumors are a cancer that causes nodular tumors in sexually active dogs of both sexes, often in the genital area. This sexually transmitted disease is also referred to as Sticker’s sarcoma, venereal granuloma, infective venereal tumor, and transplantable lymphosarcoma. Tumors of this type are common in stray, roaming dogs, and those residing in shelters.

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Symptoms of Transmissible Venereal Tumor in Dogs

The main symptom of this disease is the presence of tumors which are usually located in the genitals of both sexes, as well as the nasal and oral cavities. While tumor spread is uncommon, it can occur without a genital tumor being present. Locations can include:

  • Mouth 
  • Anus
  • Skin
  • Lymph nodes
  • Pharynx
  • Tonsils
  • Eyes
  • Liver
  • Muscles
  • Kidney 
  • Spleen
  • Brain

Tumors can appear as small papules or nodules, and over time, they can progress into a cauliflower-like, multi-nodular, or multi-lobulated appearance. They can range in size from 5 mm to 15 cm in diameter, and are usually firm. Tumors often ulcerate, become inflamed, and bleed easily. Other signs associated with these tumors include:

  • Bloody discharge from vaginal areas in females
  • Bloody discharge from penis in males

Causes of Transmissible Venereal Tumor in Dogs

Unlike other tumors that develop from the host’s own cells, TVT is clonal in origin, and is essentially a transplant of living cancer cells from one dog to another. While the original cell may have been a histiocyte, a type of white blood cell, TVT cells have a different number of chromosomes that do not come from the host dog.  

TVT is transferred by:

  • Sexual contact 
  • Direct contact with the infected tumor, such as by licking, sniffing, scratching, or biting
  • Childbirth
  • Mother to puppies through grooming

Diagnosis of Transmissible Venereal Tumor in Dogs

Most often, the presence of a tumor in the genital region will prompt a veterinary visit. A physical examination may include a digital vaginal examination in females, and possibly a vaginoscopy, as tumors can grow inside the vagina and be hard to see. A diagnosis is based on symptoms, the presence of tumors, and the results of testing.

A urinalysis is performed, along with blood tests that include a CBC and serum analysis, all of which can rule out the presence of parasites that can cause many of the same symptoms. It can also reveal abnormalities that can point to organs that may be affected. Tissue samples can be collected by a fine needle aspiration, surgical excision, or punch biopsy, and are analyzed to discover the nature and type of tumor your dog has. This tumor has a characteristic appearance which can help to diagnose this particular type of cancer.  

If it is suspected that internal organs may be affected, imaging techniques such as X-rays and ultrasounds can be used to reveal internal masses and organ damage.

Treatment of Transmissible Venereal Tumor in Dogs

In some dogs, tumors can trigger an immunologic response that can result in spontaneous regression of the tumor. Often, tumors will grow rapidly, then remain at a certain size before regression can occur, after which your dog may be resistant to a future implantation of TVT cells.

In dogs whose immune systems are unable to properly respond, tumors will continue to grow and spread into other areas, and will need to be treated. Surgical excision of small or localized tumors can be effective, but may not be the best choice when external genitalia is affected, and also carries the risk of tumor implantation into surgical wounds from instruments and gloves that have become contaminated. Recurrence has been seen to occur even in successful tumor removal. Most often, surgery is followed by other therapies.

Radiation therapy has been effective, while chemotherapy remains the best way to treat these tumors. Various chemotherapy medications can be administered over the course of 4 to 6 weeks, and can result in complete remission. 

Another experimental method is the use of biotherapy, or biologic response modifiers. These are antigen vaccines, growth factors, or immunomodulators that change the tumor’s relationship with the host by affecting the tumor directly, or it’s environment.

Recovery of Transmissible Venereal Tumor in Dogs

Recovery from TVT can be good. Some tumors can spontaneously regress without treatment. Tumors that require treatment have a 90% chance of complete remission with the right therapies. Recurrence of the tumors can occur, but is much less likely with the use of radiation or chemotherapy. If the tumors have spread to internal organs, there may be further complications that can compromise recovery. If this is the case with your dog, your veterinarian will discuss your dog’s chances of recovery based on his particular case.  

After any surgery, you may need to monitor wounds and change bandages, as well as administer any post-surgery medications. Watch for swelling or bleeding at the surgery site, and report them to your vet. You may need to take your dog in for scheduled weekly treatments. 

TVT is spread through sexual or direct contact with tumors. Preventing this disease may be difficult if you do not know the health status of your dog, or other dogs he may come into contact with. If you know your dog has TVT, prevent him from having any physical contact with other dogs, including licking, biting, rubbing, or mating. Be sure to wash your own hands after contact with your dog to prevent spreading the living cells to other dogs as well.

Transmissible Venereal Tumor Questions and Advice from Veterinary Professionals

Many
Kintamani
1 Year
Moderate condition
1 found helpful
Moderate condition

Has Symptoms

TVT tumours

How is TVT cancer different from other cancers that dogs get? Are there any statistics on the success of this type of chemo/ Is it the same chemo as given to humans? i am helping an animal rescue group in Indonesia and are seeing a growing number of cases. Thank you.

Dr. Michele King, DVM
Dr. Michele King, DVM
1607 Recommendations
Each type of cancer is different, in dogs and people. TVT can regress on its own, or may need chemotherapy, and I'm not sure that there is a central database with statistics on success. One thing that may help if they are seeing more cases would be to spay and neuter the dogs, if they aren't already, as sexual contact is one way that it is spread. For more information: https://wagwalking.com/condition/transmissible-venereal-tumor

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Dottie
Lhasa Apso
8 Years
Moderate condition
0 found helpful
Moderate condition

Has Symptoms

Large Inflamed hard lump below anus

Hello, I just got back from the bet and my dog has been diagnosed with a TVT. My dog has not mated with or had interaction with other dogs other than her sister so I am confused as to how this happened. Now, I am concerned that her sister may end up getting it. The vet said it is highly unlikely that her sister will get it but I am not convinced. Please let me know if you have any information as to how she could have gotten a TVT if she has never had interaction with other dogs. I am worried now about her sister.

Dr. Callum Turner, DVM
Dr. Callum Turner, DVM
3317 Recommendations
Whilst a first assumption is that this tumour is transmissible through mating, it is also possible for the oral and nasal cavities of dogs to be affected by this tumour too so social behaviour like sniffing and licking may also transmit the tumour. These tumours may spontaneously resolve, but normally chemotherapy is required. Regards Dr Callum Turner DVM

Just found out that I dog I fostered has TVT. The rescue says her tumor is inside her vulva, so direct exposure means no risk to my dogs. This dog was previously said to be in sort of a false heat cycle as she was bleeding despite a spay. She wore a diaper most of the time I had her but also had breaks from it to clean herself up. I'm worried sick that my dog and other foster dog were exposed through this bloody discharge and/or even sharing a water bowl. My vet has little info on the risk of indirect exposure. Any info?!

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