Antihistamines Poisoning in Dogs

Antihistamines can be found in over-the-counter cold, allergy, and sinus medications. Antihistamines are used by humans to treat a variety of conditions, such as allergies and sinus ailments. Antihistamines may also contain combination ingredients, such as aspirin, codeine, caffeine, dextromethorphan, and pseudoephedrine. Common brands of antihistamines include Dimetane, Zyrtec, Chlor-Trimeton, Tavist, Benadryl, Allegra, and Claritin. If a dog has ingested antihistamines, it will be very important to take the box that contained the medication with you to the veterinarian so the ingredients will be known.

Antihistamines come into categories: first-generation and second-generation. First-generation antihistamines, when taken, have a sedative effect. Many people refer to these as the “older” antihistamines since they can cause marked drowsiness, unlike the second-generation medications. They can also cause blurry vision, dry mouth, difficulty with coordination and concentration, and nausea. The second-generation antihistamines are purchased more often since they are in non-drowsy form; however, if they are taken above the recommended dosage they can still have the same side-effects as first-generation antihistamines.

Antihistamines poisoning in dogs occurs when dogs ingest a quantity of medications, either over-the-counter or prescription, that contain antihistamines. This type of toxicity is treatable if immediate medical attention is given.

When dogs overdose on antihistamines, symptoms depend on the quantity consumed. Symptoms of antihistamine poisoning in dogs include:

• Rapid heartbeat
• Irregular heartbeat
• Hyperactivity
• Seizures
• Vomiting
• Confusion

Types

It is important to know the type of antihistamine your dog ingested and the ingredients contained in combination with the particular medication. Differential diagnoses of antihistamine poisoning in dogs include:

• Amphetamine poisoning
• Caffeine poisoning
• Pseudoephedrine overdose
• Alcohol toxicity
• Marijuana toxicity
• Barbiturates or tranquilizer overdose

When a dog consumes antihistamines, depending on the amount ingested, toxicity can occur. Poisoning due to antihistamine overdose is caused by:

• The constriction of the smooth muscles in the respiratory tract
• The increased permeability of the capillaries
• Negatively affects the central nervous system
• Cardiovascular abnormalities

Once the veterinarian has made a diagnosis of antihistamine poisoning, he will immediately begin treatment. Treatment methods include:

Emesis

If your dog has already vomited, the veterinarian will not need to induce vomiting. The induction of vomiting may be conducted in order to help rid the dog of the substance. Once emesis has occurred, the dog should display natural gastrointestinal decontamination, or the veterinarian will give the dog activated charcoal to aid in the absorption of any residual toxic substances.

Medications

Medications to suppress the central nervous system may be given, especially if the dog is having seizures. Diazepam is often the drug of choice to control any seizure activity, and there are other drugs that work as well. Medications, namely methocarbamol, guaifenesin, or pentobarbital may also be used.

Monitoring of Systems

The veterinarian will closely monitor the dog’s heart rate, arrhythmia, and respiratory rate. The monitoring of systems also is dependent upon if the animal ingested a medication that has been combined with the antihistamine.