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- Best Calming Treats for Dogs with Separation Anxiety 2025
Written by Emily Bayne
Veterinary reviewed by:
Published: 09/27/2023, edited: 01/30/2025
The Wag! team conducts independent research and consults pet experts to curate our recommendations. This content is supported by our affiliate pet partners and we may receive a commission on the links provided.
Best option at big box stores
Zesty Paws Advanced Calming Bites
Why Wag! loves Zesty Paws Advanced Calming Bites
- You won't have to go on a wild goose chase to track these treats down since you can find them at most big box stores.
- Nervous and hyper puppies rejoice — Zesty paws calming treats also come in a puppy version!
- Are the regular zesty bites too big for your pet’s preference? No problem! They come in a mini version too!
- With natural herbs and amino acids as the active ingredients, this is a formula you can feel confident about giving to your babies.
- My dog goes paws-it-vely bananas for the tasty turkey flavor!
Considerations & concerns
- If you have a peanut allergy, be cautious about which flavors you choose.
- They have a turkey flavor, which is peanut-free, but the flavors on the packaging are in tiny letters, so make sure to pay close attention if you have food allergies.
Vet recommended
Elllevet Calm and Comfort Hemp Chews
Why Wag! loves Ellevet Calm and Comfort Hemp Chews
- Formulated by vets and backed by science
- Small batch-tested so you can be certain about what you're giving your doggo
- Analyzed for purity before it hits the shelves (unlike some CBD pet products with misleading labels)
- Flavored with natural pork to get your doodles drooling!
Considerations & concerns
- Dr. Georgia warns that this product is a bit pricy — but remember — you get what you pay for!
- Currently only available through their website (not in stores)
Best sustainably sourced calming chew
Open Farm Calming Treats
Why Wag! loves Open Farm Calming Supplement Chews for Dogs
- Quality, traceable ingredients (You can check out their websites for the origins of each of their ingredients!)
- Made with whole foods like apples, sweet potatoes, oats, and honey rather than yucky artificial flavorings!
- Ingredients that support healthy digestion and calm the stomach (There's nothing worse than an anxious dog with an anxious stomach to boot!)
Considerations & concerns
- Some pet parents say they have trouble getting picky pets to eat these treats, while others say their dogs scarf them right down.
Best in-store option
Only Natural Pet Calming Chews
Why Wag! loves Only Natural Pet Hemp Calming Support Soft Chews
- My dog gives these treats 4 paws up for their smoky flavor.
- These offer mild sedative effects that are great for mild anxiety or between doses of his prescription meds
- The soft, chewy texture would make these great for dogs with dental issues
- The airtight, screw-on lid keeps things fresh and mess-free
- Easy to break apart for accurate dosing.
- Batch-tested for accuracy.
Considerations & concerns
- The CBD calming chews from this same brand are our absolute fave — however, due to red tape surrounding CBD sales in some states — they are only available in select pet stores and not available at all online.
- These hemp chews tend to make my dog hungry/eat more, so keep this in mind if your dog hasweight issues.
VetriScience Composure Calming Treats
Why Wag! loves Vetriscience Composure Calming Treats a stale treat?!)
- Also comes in an extended-release version for long-acting anxiety relief (a great choice for road trips or a day spent at the groomer)
- Uses a high-quality form of L-theanine, called "Suntheanine," rather than the lower-quality alternatives.
- Third-party testing ensures accurate results (and no skewed data in favor of the product!)
- Uses natural preservatives like rosemary and tocopherols
Considerations & concerns
- Some Vetriscience products contain peanutflavoring, so be sure to check the packaging if you or someone in your home has an allergy.