Baytril for dogs

Written By Alex Olsson
Published: 07/21/2020Updated: 10/04/2024
Veterinary reviewed by Dr. Linda Simon, MVB MRCVS
Baytril for Dogs | Wag!
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Baytril is the brand name for the antibiotic ‘enrofloxacin’ — it’s a powerful antibiotic commonly prescribed by vets to treat bacterial infections in dogs. Baytril belongs to the fluoroquinolone class of antibiotics, which are effective against a wide range of bacteria. 

And while Baytril is a trusted medication for your furry friend, it’s essential for dog owners to understand its proper usage, the importance of follow-up vet care, and how to administer it correctly to ensure the best outcomes for their pets.

Let’s take a closer look at Baytril for dogs and explore everything you need to know.

What is Baytril used for in dogs?


Primarily, Baytril is used to treat bacterial infections in dogs, including:


Baytril is often chosen for infections that can be resistant to other antibiotics, making it a valuable tool in a vet’s arsenal.

How does Baytril work?

The active ingredient in this antibiotic, enrofloxacin, works by prohibiting DNA replication of the bacteria, essentially blocking it from being able to reproduce within the host. 

Is your pup getting tired of eating bland food while they’re sick? Find a new favorite instead — try out some of our picks for best high-protein dog foods for when they’re feeling better. 



What’s the right Baytril dosage for dogs?

The dosage of Baytril for your pup will depend on the type and severity of the infection, in addition to your dog’s weight. Typically, the dosage ranges from 5 to 20 mg/kg (2.27 to 9.07 mg/lb), administered once daily for a prescribed amount of time. 

But it’s important to follow your vet’s instructions, as your pup’s specific dosage may be adjusted based on their individual needs.

Note: Baytril is available in different forms, including oral tablets, injectables, and ear-drop (otic) solutions. The form prescribed by your dog’s vet will depend on the type of infection being treated.


How to administer Baytril

As most pet parents probably know, administering medication to dogs can be challenging — especially with oral tablets. Here’s a step-by-step guide to ensure successful administration:


Giving Baytril tablets:

Pill pockets: Place the tablet inside a pill pocket or treat designed to hide medication and offer it to your dog as a treat.

Mix with food: Crush the tablet (only if your vet approves) and mix it with a small amount of your dog’s favorite food. Make sure they eat the entire portion to get the full dose.

Manual administration: If your dog refuses treats or food, try manually placing the tablet at the back of your dog’s tongue and gently holding their mouth closed until the tablet is swallowed.


Administering liquid form:

Directly measure the dose: Use a syringe or dropper provided by your vet to measure the exact dosage. Insert the syringe into the side of your dog’s mouth, near the cheek, and slowly release the medication. Ensure your dog swallows it completely.


Baytril injection for dogs:

This form of Baytril is usually reserved for severe infections or when oral administration is not possible. It's vital to follow up on these injections with regular check-ins with your vet.


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Are there any dogs that shouldn’t/can’t take Baytril?

Dogs who are dehydrated, allergic, or hypersensitive to Baytril shouldn’t take this medication. Due to Baytril’s effects on joint cartilage in growing dogs, it should also not be given to puppies aged 28 weeks or under.

Exercise extreme caution when giving the medication to dogs who are prone to seizures, or who suffer from kidney disease or liver disease

Additionally, caution should also be used when giving Baytril to pregnant dogs.

Baytril for dogs: side effects


Like all medications, this antibiotic can cause side effects. Some of the most common side effects of Baytril for dogs include:

  • Stomach problems: Vomiting, diarrhea, and reduced appetite are the most frequent side effects. (If your dog starts to suffer from diarrhea, try out some of the best dog foods for diarrhea to get their system back on track.)
  • Behavioral changes: Some dogs may become lethargic or show signs of depression.
  • Sensitivity to light: Increased sensitivity to sunlight may happen, so be sure to limit your dog's sun exposure during treatment.


What about more severe side effects? Though they’re on the rare side, serious side effects require immediate vet attention, and may include:


Drug interactions with Baytril

Is your dog currently on any other medications? If so, make sure to let your vet know before they prescribe Baytril, since it may interact with the following medicines:

  • Antacids
  • Antibiotics
  • Corticosteroids
  • Cyclosporine
  • Doxorubicin
  • Flunixin
  • Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Probenecid
  • Phenytoin
  • Sucralfate and zinc salts
  • Theophylline
  • Warfarin

Besides these, Baytril may even interact with other medications — so it’s important to inform your vet about all medications your dog is currently taking.

It’s also worth pointing out that dairy, iron, aluminum, and some calcium products can inactivate enrofloxacin. During the course of their medication, try to steer clear of these products to let the antibiotics do their best work.

Why it’s important to follow up on vet visits


Administering Baytril to your pup isn’t just about giving the medication; it's just as important to monitor your dog’s progress. Regular vet visits allow your vet to assess whether the infection is responding to treatment and to check for any side effects. 

Antibiotic resistance can develop if Baytril is not used properly, so consistent follow-up is essential to ensure the treatment's effectiveness and to make any necessary adjustments.

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Managing long-term antibiotic use to avoid resistance


Long-term use of antibiotics like Baytril can eventually lead to antibiotic resistance, where bacteria become less susceptible to the medication. 

To manage this risk, make sure you:

  • Complete the full course of medication: Always finish the entire prescribed course, even if your dog seems better. Stopping early can lead to incomplete treatment and eventually resistance.

  • Report any side effects immediately: If your dog shows signs of adverse effects, such as vomiting, diarrhea, or loss of appetite, contact your vet immediately. These could indicate that the medication may need to be adjusted or stopped.

How much does Baytril cost?


The cost of Baytril varies depending on the dosage and form prescribed. Individual tablets range in price from 85¢ to $4 for a 22.7 and 136 mg dosage, respectively.

Generic forms of Baytril are a little cheaper, at 65¢ to $3 per tablet. A 15 ml bottle of Baytril ear drops costs $20 on average.


Storing Baytril

This medication should be stored in a dry, tightly-sealed container at room temperature. Always keep it away from direct sunlight. 


Frequently asked questions

What should I do if my pet has a Baytril overdose?

If you suspect your dog has had an overdose, seek vet help immediately. You can also drop a question in our vetcare chat


Will my dog like the taste of Baytril?

Baytril has a very bitter taste that may cause your dog to refuse the medication. Flavored tablets are available to help make the drug more palatable.


Why was Baytril banned?

In 2005, the FDA banned the use of Baytril in poultry (chickens, turkeys, etc.) as it was believed to potentially lead to antibiotic-resistant infections in humans. The drug is deemed safe to use by the FDA for use in dogs, cats and other animals without issue.


How long does it take for Baytril to work?

This fast-acting antibiotic can start working already within 1-2 hours of the first dose, but it may take a few days for your pup to really start feeling better. 

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