What are Anaplasmosis?
Anaplasma phagocytophilum was previously referred to as Ehrlichia. The disease is transmitted to the horse, through the bite of an infected deer tick which carries Anaplasma phagocytophilum. Once the organism is in the horse’s bloodstream it causes the inflammation of the white blood vessels. The disease may vary from showing no noticeable symptoms to potentially becoming life threatening. Horses that are younger than four years old usually only develop mild symptoms such as a fever and or depression. Adult horses typically may have more critical symptoms. Signs of the disease may be visible 1 to 12 days post-inoculation.
Clinical infection of Anaplasma phagocytophilum have been confirmed in Connecticut, Washington, Arkansas, Pennsylvania, Illinois, Colorado, New York, Massachusetts and in Florida. It has also been found in other countries such as Sweden, Great Britain and South America.
Anaplasmosis in horses (Equine Granulocytic Ehrlichiosis) is a seasonal tick-borne transmitted disease. The disease is caused by the intracellular organism Anaplasma phagocytophilum.
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Symptoms of Anaplasmosis in Horses
Symptoms will be more severe as the disease progresses; clinical signs may also vary depending on the age of the horse. Symptoms may include one or more of the following:
- Edema - retaining fluids
- Respiratory infection
- Less active
- Body soreness
- Lack of appetite
- Increased heart rate
- Yellow gums
- Small red lesions on the gums and sclera
Causes of Anaplasmosis in Horses
Anaplasmosis (Equine Granulocytic Ehrlichiosis) is caused by the organism Anaplasma phagocytophila. Anaplasma phagocytophila is transmitted by the bite of an infected deer tick. It is commonly believed that a tick must be attached for 24 hours before the disease is transmitted.
Diagnosis of Anaplasmosis in Horses
The equine veterinarian will take a thorough medical history of your horse. He will discuss what clinical signs you have observed. Let him know if you have seen ticks on your horse or on another horse in the stalls. The veterinarian will then perform a physical exam on your horse which may include taking the horse temperature, listening to his heart and lungs, and palpation of the abdominal and chest area.
The veterinarian will take a complete blood count (CBC), serum chemistry panel and perform a urinalysis. The CBC will determine if your horse has decreased platelets and low red and/or white blood cells; all clinical signs of anaplasmosis. A serum chemistry panel can help rule out any underlying diseases. Urinalysis will show if the horse has any kidney issues and if there is bacteria, sugar, crystals or blood in the urine. The veterinarian may also recommend a standard blood smear and SNAP 4dx, which tests for antibodies.
Treatment of Anaplasmosis in Horses
If your horse is diagnosed with anaplasmosis he will be treated with antibiotics (tetracycline or doxycycline) and anti-inflammatory (phenylbutazone or banamine) medications. Initially, medications may be given intravenously and then administered orally. If your horse has leg edema (retained fluids) he may be placed on corticosteroid medication. Anaplasmosis may have caused your horse not to drink and eat normally. He may be dehydrated and will need fluids administered through an IV. Stalls will need to be cleaned out and inspected for ticks.
Recovery of Anaplasmosis in Horses
The horse will need follow-up visits to check on his progress and to have a retake on the bloodwork. Horses usually feel better with 24 hours of the start of treatment. It is important to follow the veterinarian’s treatment plan, to ensure that the anaplasmosis has been eradicated from the horse’s bloodstream. In rare cases, horses recovering from anaplasmosis may suffer a relapse. Contact your veterinarian if your horse starts to show any of the previous symptoms.
Horse that have recovered from anaplasmosis are immune to the disease for approximately two years. There is no vaccine for anaplasmosis; it is important to protect your horse from ticks. There are insecticides that can be sprayed along that perimeter of the pasture to help kill ticks. There are also tick repellants that can be used directly on the horse; ask your veterinarian what he recommends. Ticks like damp, overgrown, shady areas; horses should not be allowed to be where there is tall, unmaintained grass.
Horses should be checked daily for ticks. If you find a tick on your horse; use a fine-tipped tweezer to remove it. Use the tweezer to grab the tick as close to its head (where he is attached to the horse) and pull it straight out. Do not grab the tick by the swollen belly, which is full of blood. You can apply a local antiseptic to clean the bite area.
Anaplasmosis Questions and Advice from Veterinary Professionals
My horse in Upstate New York has been diagnosed with anaplasmosis based on symptoms and a PCR test. His symptoms began with a lack of energy, and loss of appetite followed by gradually increasing elevated temperature (from 99.5 to 100.5 to 100.9, 101.5 and 102.9, accompanied by stocking up in all four legs and when his urine was red, the vet was called. She sent his blood out for analysis and administered 3 days of IV doxycycline. She did a CBC and his platelets were extremely low. The vet recommended 1 month of oral doxycycline. Following the IV, his temperature returned to normal, his legs are not stocking up, his urine is pale yellow and his appetite seems to be gradually returning. The PCR test was positive for anaplasmosis and according to the vet, "a low positive for chronic Lyme disease". Based on that, the vet recommended keeping him on oral doxycycline for six weeks.
My question: Is there a recommended time to continue the oral doxycycline? Is six weeks appropriate?
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My 6 yo Clydesdale gelding is being treated for anaplasmosis. It's February in Virginia. About 3 weeks ago, I noticed the first problem. He wouldn't turn his head to the left at all--not even so much as a nose tilt for a treat. Otherwise he seemed fine and happy. I gave him 2 grams of bute a day for 3 days. 4 days later he was turning to the left a little better, so I rode him at the walk. But he wore me out in wanting to bear right and not able to turn left. I did get him to trot on the longe line both directions and he was perfectly sound. But I knew something was wrong, so called the vet. The vet did a full exam including neurological and suspected it was a shoulder injury. He had been out playing in the mud many times. The vet drew blood to do some general tests just for good measure. The blood work all came back normal except for an elevated SAA (inflamation marker) Meanwhile, my horse got sicker and sicker. It was obviously something systemic and not just a shoulder injury. He stopped eating and refused to come out of his stall. He wanted to lean on the wall or lay down all the time.
The vet started him on IV oxytetracycline for 3 days and did a test for tick born diseases. That came back 3 days later positive for anaplasmosis. We then started oral doxycycline. He's been on that for 4 days now.
So far, there's been improvement but very little. He's now willing to eat slowly and puts his ears up to listen when you're talking to him. That's an improvement from where he was.
My 34 year old pony with Cushings has been walking in circles to the right for weeks. The vet thought it was progression of her Cushings to end stage but I asked for a Lyme test today and she turned up positive for anaplasmosis. She refuses to turn to the left she brazes in circles to the right. I thought she had some neurological disease and was about to put her down but now we will try doxy and see if she snaps out of it. Thanks for your story.
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Hello. Is there anything in a regular blood panel that may indicate anaplasmosis? I am suspicious and wonder why we have not checked. My horse became very ill after being out on winter pasture in mild winter weather on Cape Cod. Possible?
My 18 y/o walking horse showed some stiffness in hind quarters and was told that she was getting to much green grass so I cut that out , the next day she was down and could not get up . Called the dvm . came out did some blood work test ,heart worm/dz test stating it was positive for anaplasmosis.Was treated with iv banamine and bio-mycin . Rectal temp 99.9 lungs clear, heart regular , rate was not elevated. good bowel sounds. non tender with palpation. passing gas. still good appetite gums pale, some yellowing and sclera some yellowing .It seems like she was paralyzed in hind quarters and looked like some type of seizure activity , facial , arching of neck and both front legs rigidity . This sight and her nicker was heart breaking. The next day she was dead having worn a circular path in the ground in attempts to get up I guess . Can you give me any insight on this .? I have a full brother without symptoms at present other than a mournful nicker. Thank you
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Does Anaplasmosis cause back and hip tenderness? My vet was out today and diagnosed my 7 year old mare with this condition with no bloodwork or any clinical testing. Just concerned for 2 years ago I had a 7 year old pony gelding that was diagnosed the same by the same vet with no bloodwork as well.I find this strange for both my mare and gelding are chesnuts. My vet has recommended 2 weeks of Doxycycline for the mare and the same 2 years ago for the pony gelding. The gelding never did get his back soreness straightened out thus the reason I sold him. Am I worrying for no reason? We show in the Hunter world and I have been loyal to my vet for years. I'm just not sure now.
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